Search results for "Stage"
showing 10 items of 1393 documents
Morphological and biomolecular charachteristics of subcentimetric invasive breast carcinomas: a sicilian multicentric retrospective analysis
2010
Creep effects and stress adjustments in cable-stayed bridges with concrete deck
2010
In construction stages of cable-stayed bridges with prestressed concrete deck, the influence of creep on stresses and strains is very important in order to foresee the final patterns of internal forces and displacements. In cantilever construction, the concrete deck can be considered, in each stage, as a continuous beam resting on elastic restraints, which modify with successive additions of new segments, until the last one has been assembled. In these stages stress relaxation in concrete occurs as well as vertical displacements increase. Ehen structure has been closed by inserting midspan segment, stress redistribution begins, due to creep. Deformation and internal force development in con…
An empirical evaluation of business model canvas in software startups : a team perspective
2019
Business model canvas is a commonly used tool among software startups. The tool aims to help companies develop business models and new strategies. Even though the model has been widely adapted among software startups a lack of scientific research regarding the topic can be found. This thesis evaluates how the business model canvas should be further devel- oped when it comes to early stage software startups. This is done with a team perspective. First, an understanding of software startups is created. Secondly, based on the literature the Team Component is presented including the con- structs of resources, networks, self-organization and way of working. After this, the scope is widened to bu…
Food safety risk analysis from the producers' perspective: prioritisation of production process stages by HACCP and TOPSIS
2018
[EN] From the manufacturers perspective, the Hazard Analysis and Critical Control Point (HACCP) system nowadays represents the mainly way to implement the food safety risk management in food industries. Nevertheless, the identification and prioritization of hazards as the outcome of the first principle of HACCP is not sufficient to identify production process stages that more significantly and critically contribute to the consumer¿s risks. With this recognition, the present paper proposes a Quantitative Risk Assessment (QRA) approach based on HACCP and Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) to individuate production process phases on which implementing co…
High performance of intravoxel incoherent motion diffusion MRI in detecting viral hepatitis-b induced liver fibrosis.
2019
Background: Recently a small cohort study demonstrated that intravoxel incoherent motion (IVIM) diffusion MRI can detect early stage liver fibrosis. Using modified IVIM data acquisition parameters, the current study aims to confirm this finding. Methods: Twenty-six healthy volunteers, three patients of chronic viral hepatitis-b but without fibrosis and one mild liver steatosis subject, and 12 viral hepatitis-b patients with fibrosis (stage 1–2=7, stage 3–4=5) were included in this study. With a 1.5-T MR scanner and respiration-gating, IVIM diffusion imaging was acquired using a single-shot echo-planar sequence with a b -value series of 2, 0, 1, 15, 20, 30, 45, 50, 60, 80, 100, 200, 300, 600…
Oral Squamous Cell Carcinoma on Gingiva, Edentulous Ridge, and Retromolar Pad: A Case Series
2021
(1) Background: Gingival cancer has a significant incidence and is often diagnosed at advanced stages. The aim of this paper is to highlight its clinical aspects on the basis of a case series analysis in order to promote awareness and improve the diagnosis process. (2) Methods: Oral cancers diagnosed and treated at three Italian University Hospitals over ten years were retrospectively investigated. Cancer location on the gingiva, edentulous ridge, and retromolar pad was addressed. Data regarding clinical features, stage at the diagnosis, and time from presenting symptoms to first medical consultation were retrieved. (3) Results: Thirty-three cancers located on the gingiva, edentulous ridge,…
Tomographic study of Jaw bone changes in patients with bisphosphonate-related osteonecrosis
2020
Background Bisphosphonates (BP) are synthetic pyrophosphate-like substances with antiresorptive properties and specifically affect osteoclastic activity. In 2007, the American Association of Oral and Maxillofacial Surgeons (AAOMS) defined diagnostic criteria for Osteonecrosis of the Jaws Associated with Bisphosponates (BRONJ). BRONJ is mainly diagnosed by clinical features, but the detection of early bone changes by imaging may help prevent and better understand the disease. The objective of this study was to evaluate maxillary changes in CBCT in patients using BP. Material and methods All included patients were diagnosed with osteonecrosis and received bisphosphonate drugs in the last ten …
The use of morphokinetics as a predictor of embryo implantation.
2011
Background Time-lapse observation presents an opportunity for optimizing embryo selection based on morphological grading as well as providing novel kinetic parameters, which may further improve accurate selection of viable embryos. The objective of this retrospective study was to identify the morphokinetic parameters specific to embryos that were capable of implanting. In order to compare a large number of embryos, with minimal variation in culture conditions, we have used an automatic embryo monitoring system. Methods Using a tri-gas IVF incubator with a built-in camera designed to automatically acquire images at defined time points, we have simultaneously monitored up to 72 individual emb…
Synthesis of fluorinated amino acid derivatives through late-stage deoxyfluorinations
2018
Abstract Fluorine chemistry has represented a hot topic in drug research over the last decade. Because of their pharmaceutical potential, fluorine-containing amino acids and related derivatives have acquired high importance among medicinal chemists. Therefore their synthesis and the development of various synthetic methods for these types of molecular scaffolds have gained increasing interest in synthetic organic chemistry. The current review focuses on synthetic protocols towards fluorine-containing amino acid derivatives through late-stage fluorination with various nucleophilic reagents, describing the access of various open-chain and cyclic α-, β-, γ-amino acid derivatives.
A Specific Radioimmunoassay for the Determination of Low Quantities of Indole-3-acetic Acid in Spruce Needles of Healthy and Damaged Trees
1988
Summary The aim of the present investigation was to develop a radioimmunoassay for the quantification of indole-3-acetic acid in needles of Picea abies in damaged and phenotypically healthy trees. Phenols, lipophilic substances or compounds with cross-reactivity had to be separated from the extracts in several purification steps. Measurements were carried out between May and October 1986 on trees from two spruce plantations. Marked differences were found in IAA content in needles of healthy and damaged trees. In most cases the needles of the damaged trees contain lower endogenous IAA levels. The auxin levels also depended on the age of the tree, the year of needle formation, and the vegetat…