Search results for "Stain"
showing 10 items of 5524 documents
Towards Shipping 4.0. A preliminary gap analysis
2020
Abstract The paradigm of Industry 4.0 involves a substantial innovation to the value creation approach thought the supply chain and the application of digital enabling technologies like the Internet of Things (IoT), Big Data Analytics (BDA) and cloud computing. The fourth industrial revolution is thus expected to have a disruptive impact on maritime transport and shipping sectors, where smart ships and autonomous vessels well be part of a new and fully interconnected maritime ecosystem. Specific hardware components, such as sensors, actuators, or processors will be embedded in the ship’s key systems in order to provide valuable information to increase the efficiency, sustainability and safe…
The Integration of the Supply Chain as a Dynamic Capability for Sustainability: The Case of an Innovative Organic Company
2018
Numerous research projects have demonstrated that a firm’s ability to integrate, build, and reconfigure internal and external competencies to adapt to changes in its environment is a key capability for its competitiveness. However, in the case of developing the capabilities needed to implement innovation, we have found that the ability to integrate knowledge into the supply chain is also crucial since it is an essential requirement for bringing in technological change and product innovation. The purpose of this chapter is to understand the role of supplier integration in the implementation of radical innovation. First, we propose a theoretical model to connect supplier integration as a dyna…
Ranking corporate sustainability: a flexible multidimensional approach based on linguistic variables
2017
Corporate sustainability implies a compromise between the present environmental, social, and economic needs of a firm's stakeholders and their future needs. Corporate sustainability is therefore a multidimensional concept. Nowadays, several independent rating agencies rate firms in terms of environmental, social, and governance (ESG) criteria. These ratings are usually used by main sustainability indices such as the Dow Jones Sustainability Index, FTSE4 Good, Stoxx Sustainability Index, or Euronext Vigeo Family to select companies to invest in. Only those firms performing better than the average of their sector are selected. However, although providing linguistic ratings about the performan…
How selection of collaborating partners impact on the green performance of global businesses? An empirical study of green sustainability
2020
In recent days, both collaboration and sustainability have become an integral part of many global supply chains to achieve business excellence. Although previous literature and actual practices confirmed the successful implementation of sustainability practices through supply chain collaborations, it is not clear how collaborating partners can support financial and environmental performance, and hence strengthen the partnership performance in the global supply chains. To address this practice-based research question, we test the theoretical underpinning of suppliers and logistics partners in relation to required skills selection. We capture the depth of interdependencies in collaborations f…
Climate Change and Disasters
2017
Ideas and approaches proven successful within disaster risk reduction (DRR) literature and practice are either bypassed or inadequately considered by contemporary climate change work. This chapter explores the intersections between climate change and hazards, vulnerability, and risk, looking at climate change as both a hazard driver and a hazard inhibitor. The implications of the narrow interpretations of vulnerability employed in climate change work are examined, as well as the ways in which climate change has come to act as a scapegoat for issues, events, and processes caused by hazard-independent factors. The chapter formulates a case for climate change adaptation (CCA) to be seen as a s…
Preventive maintenance versus cost of repairs in asset management: An efficiency analysis in wastewater treatment plants
2020
Abstract The operation and management of Wastewater Treatment Plants (WWTPs) is of paramount importance to guarantee the sustainability of water resources. Just like any other production process, wastewater treatment process involves different costs, such as: energy, personnel, maintenance and reagents. Regarding maintenance costs, they have become an issue of great concern to many operators in the last years. Maintaining the facilities in good condition ensures the proper performance of these infrastructures and reduces the risk of failures. It should be known that equipment breakdowns imply an increase in operating costs, with a high risk of generating an environmental damage due to the m…
Sustainable growth and environmental catastrophes
2017
Abstract In the standard AK growth model we introduce the threat of an ecological catastrophe and study the consequences for the economic variables in the long-run. We extend the basic framework by considering two environmental externalities: the first one is local and gives account of the marginal damage from emissions flow; the second one is aggregate, or global, and relates to the extreme damage which may happen if the accumulated stock of pollutants is on the threshold of a worldwide catastrophe. In this context dominated by market failures, we focus on the socially optimal solution and the search of conditions for sustainability. We identify the efficient balanced growth path, which ma…
Improving tumour budding evaluation in colon cancer by extending the assessment area in colectomy specimens.
2019
AIMS It is recommended that tumour budding in colon cancer be counted on haematoxylin and eosin-stained sections in a hotspot area of 0.785 mm2 with a ×20 microscope objective. However, tumour buds may be difficult to visualise on haematoxylin and eosin-stained sections, and counting in such a limited area may result in overestimation in cases with focal budding. The aim of this study was to assess the contributions of various factors to improving tumour budding risk stratification: increasing the number of fields counted, using cytokeratin immunostaining, and recording proliferation, the apoptotic index and the emperipoletic index in tumour buds. METHODS AND RESULTS We created an explorato…
Expression of NF-κB and IL-6 in oral precancerous and cancerous lesions: An immunohistochemical study.
2014
Background The purpose of this study was to evaluate the immunohistochemical expression of NF-κB and IL-6 in oral premalignant and malignant lesions and to investigate their possible correlation with the presence of subepithelial inflammation. Material and Methods Thirty two oral premalignant lesions, clinically compatible with leukoplakia or erythroplakia, were investigated. Microscopically, 11 of them showed hyperkeratosis and acanthosis (epithelial hyperplasia) and 21 showed dysplasia of varying degrees. Nine cases of OSCC and four control cases of normal oral mucosa were also included in the study. Immunohistochemical staining with NF-κB (p65) and IL-6 was performed. IL-6 and nuclear NF…
Endothelial cell damage is the central part of COVID-19 and a mouse model induced by injection of the S1 subunit of the spike protein☆
2021
Neurologic complications of symptomatic COVID-19 are common. Brain tissues from 13 autopsies of people who died of COVID-19 were examined. Cultured endothelial and neuronal cells were incubated with and wild type mice were injected IV with different spike subunits. In situ analyses were used to detect SARS-CoV-2 proteins and the host response. In 13/13 brains from fatal COVID-19, pseudovirions (spike, envelope, and membrane proteins without viral RNA) were present in the endothelia of microvessels ranging from 0 to 14 positive cells/200× field (mean 4.3). The pseudovirions strongly co-localized with caspase-3, ACE2, IL6, TNFα, and C5b-9. The surrounding neurons demonstrated increased NMDAR2…