Search results for "Standard"
showing 10 items of 3299 documents
Randomized Controlled Trials and real life studies. Approaches and methodologies: a clinical point of view.
2014
Randomized Controlled Trials (RCTs) are the "gold standard" for evaluating treatment outcomes providing information on treatments "efficacy". They are designed to test a therapeutic hypothesis under optimal setting in the absence of confounding factors. For this reason they have high internal validity. The strict and controlled conditions in which they are conducted, leads to low generalizability because they are performed in conditions very different from real life usual care. Conversely, real life studies inform on the "effectiveness" of a treatment, that is, the measure of the extent to which an intervention does what is intended to do in routine circumstances. At variance to RCTs, real …
Towards the determination of isoprene in human breath using substrate-integrated hollow waveguide mid-infrared sensors
2014
Selected volatile organic compounds (VOCs) in breath may be considered biomarkers if they are indicative of distinct diseases or disease states. Given the inherent molecular selectivity of vibrational spectroscopy, infrared sensing technologies appear ideally suitable for the determination of endogenous VOCs in breath. The aim of this study was to determine that mid-infrared (MIR; 3-20 µm) gas phase sensing is capable of determining isoprene in exhaled breath as an exemplary medically relevant VOC by hyphenating novel substrate-integrated hollow waveguides (iHWG) with a likewise miniaturized preconcentration system. A compact preconcentrator column for sampling isoprene from exhaled breath …
Efficacy of Immune Checkpoint Inhibitors Alone or in Combination With Chemotherapy in NSCLC Harboring ERBB2 Mutations
2021
Abstract Introduction In contrast to other driver mutations, no targeted therapies have yet been approved in ERBB2-mutated NSCLC (HER2mu NSCLC). Nevertheless, several compounds have revealed promising early efficacy data, which need to be evaluated in the context of current standard approaches. Although data on the efficacy of immune checkpoint inhibitors (ICIs) in second or subsequent lines of treatment remain limited and conflicting, there are virtually no data on patient outcome under ICI/platinum-doublet combinations in the first-line setting. Methods We retrospectively evaluated outcomes of patients with HER2mu NSCLC treated with ICI alone or in combination with chemotherapy within the…
Physicochemical compatibility and stability of nebulizable drug admixtures containing Dornase alfa and tobramycin.
2012
The objective of this in-vitro study was to determine whether admixtures of the inhalation solutions Pulmozyme(®) (Dornase alfa) and either Bramitob(®) or Tobi(®) (both containing Tobramycin) are physicochemically compatible and to analyze the aerodynamic parameters of these admixtures. After mixing, test solutions were stored at room temperature and under ambient light conditions over a period of 24 h. Tobramycin concentrations were determined by using a fluorescence immunoassay. Stability of dornase alfa was determined by size-exclusion high performance liquid chromatography, ultraviolet spectroscopy, sodium dodecyl sulfate polyacrylamide gel electrophoresis and tentacle strong cation-exc…
Évaluation de la pratique chirurgicale dans le traitement du cancer bronchique en France à partir de la base nationale du PMSI
2019
Background - In recent years, improving the quality of care has been a concern for health professionals in France, through the certification of institutions, accreditation and continuous professional development. Evaluation of these different measures has rarely been carried out. The objective of the study was to evaluate the quality of surgical management of lung cancer in different regions using hospital mortality as an indicator. Method - From the national database of the Program of Medical Information Systems (PMSI), data on all patients who had undergone surgery for lung cancer were extracted as well as the characteristics of the centers. The main outcome criterion was hospital mortali…
Prognostic Value of Troponins in Patients With or Without Coronary Heart Disease: Is it Dependent on Structure and Biology?
2020
Convincing evidence has emerged that cardiac troponins (cTns) T and I are the biochemical gold standard for diagnosing cardiac injury, and may also be used as efficient screening and risk stratification tools, especially when measured with the new high-sensitivity (hs-) immunoassays. In this narrative review, we aim to explore and critically discuss the results of recent epidemiological studies that have attempted to characterise the prognostic value of cTns in patients with or without cardiovascular disease, and then interpret this information according to cTn biology. Overall, all recent studies agree that higher blood levels of cTns reflect the larger risk of cardiovascular events and/or…
Maximal regularity via reverse Hölder inequalities for elliptic systems of n-Laplace type involving measures
2008
In this note, we consider the regularity of solutions of the nonlinear elliptic systems of n-Laplacian type involving measures, and prove that the gradients of the solutions are in the weak Lebesgue space Ln,∞. We also obtain the a priori global and local estimates for the Ln,∞-norm of the gradients of the solutions without using BMO-estimates. The proofs are based on a new lemma on the higher integrability of functions.
Riesz and Wolff potentials and elliptic equations in variable exponent weak Lebesgue spaces
2015
Submitted by Alexandre Almeida (jaralmeida@ua.pt) on 2015-11-12T11:41:07Z No. of bitstreams: 1 RieszWolff_RIA.pdf: 159825 bytes, checksum: d99abdf3c874f47195619a31ff5c12c7 (MD5) Approved for entry into archive by Bella Nolasco(bellanolasco@ua.pt) on 2015-11-17T12:18:41Z (GMT) No. of bitstreams: 1 RieszWolff_RIA.pdf: 159825 bytes, checksum: d99abdf3c874f47195619a31ff5c12c7 (MD5) Made available in DSpace on 2015-11-17T12:18:41Z (GMT). No. of bitstreams: 1 RieszWolff_RIA.pdf: 159825 bytes, checksum: d99abdf3c874f47195619a31ff5c12c7 (MD5) Previous issue date: 2015-04
On density and π-weight of Lp(βN,R, μ)
2012
In Integration Theory, it is important to establish the separability or not of Lebesgue spaces of the type Lp, with 1 ≤ p < +∞. In general, the usual proof of this type of results for certain Lebesgue spaces, is conducted through methods of Real Analysis. In this work, we use some concepts and methods of pure General Topology in proving the non-separability of a particular Lebesgue space. Further, we provide some estimates for density and π-weight of such a space.
Quasilinear elliptic equations with singular quadratic growth terms
2011
In this paper, we deal with positive solutions for singular quasilinear problems whose model is [Formula: see text] where Ω is a bounded open set of ℝN, g ≥ 0 is a function in some Lebesgue space, and γ > 0. We prove both existence and nonexistence of solutions depending on the value of γ and on the size of g.