Search results for "Standardization"
showing 10 items of 170 documents
Characterization and multicentric validation of a common standard for Toxoplasma gondii detection using nucleic acid amplification assays.
2014
ABSTRACT The molecular diagnosis of toxoplasmosis essentially relies upon laboratory-developed methods and suffers from lack of standardization, hence the large diversity of performances between laboratories. Moreover, quantifications of parasitic loads differ among centers, a fact which prevents the possible prediction of the severity of this disease as a function of parasitic loads. The objectives of this multicentric study performed in eight proficient laboratories of the Molecular Biology Pole of the French National Reference Center for Toxoplasmosis (NRC-T) were (i) to assess the suitability of a lyophilized preparation of Toxoplasma gondii as a common standard for use in this PCR-base…
Validación y verificación analítica de los métodos microbiológicos
2015
Clinical microbiologists should ensure, to the maximum level allowed by the scientific and technical development, the reliability of the results. This implies that, in addition to meeting the technical criteria to ensure their validity, they must be performed with a number of conditions that allows comparable results to be obtained, regardless of the laboratory that performs the test. In this sense, the use of recognized and accepted reference methodsis the most effective tool for these guarantees. The activities related to verification and validation of analytical methods has become very important, as there is continuous development, as well as updating techniques and increasingly complex …
A human post-mortem brain model for the standardization of multi-centre MRI studies
2015
Multi-centre MRI studies of the brain are essential for enrolling large and diverse patient cohorts, as required for the investigation of heterogeneous neurological and psychiatric diseases. However, the multi-site comparison of standard MRI data sets that are weighted with respect to tissue parameters such as the relaxation times (T1, T2) and proton density (PD) may be problematic, as signal intensities and image contrasts depend on site-specific details such as the sequences used, imaging parameters, and sensitivity profiles of the radiofrequency (RF) coils. Water or gel phantoms are frequently used for long-term and/or inter-site quality assessment. However, these phantoms hardly mimic t…
Indicadores compuestos como metodología innovadora en Comunicación. Aplicación para la evaluación de los medios públicos europeos
2020
The currently dominant scientific production model in the field of Communication exhibits an excess of standardization towards mainly empirical work that is overwhelming caried out using quantitative techniques based on simple statistical analyses, in many cases limiting the presentation of results to a reading of the available data. This article presents an innovative proposal in this area, designed as a new form of dissemination and scientific presentation, with the objective of constructing three composite indicators that, when applied to European public service media, will enable the assessment of the perception of their social value, independence, and management efficiency. Another aim…
Standardizing the analysis of conditioned fear in rodents: a multidimensional software approach
2013
Data comparability between different laboratories strongly depends on the individually applied analysis method. This factor is often a critical source of variation in rodent phenotyping and has never been systematically investigated in Pavlovian fear conditioning paradigms. In rodents, fear is typically quantified in terms of freezing duration via manual observation or automated systems. While manual analysis includes biases such as tiredness or inter-personal scoring variability, computer-assisted systems are unable to distinguish between freezing and immobility. Consequently, the novel software called MOVE follows a semi-automatized approach that prefilters video sequences of interest for…
How to standardize (if you must)
2017
In many situations we are interested in appraising the value of a certain characteristic for a given individual relative to the context in which this value is observed. In recent years this problem has become prominent in the evaluation of scientific productivity and impact. A popular approach to such relative valuations consists in using percentile ranks. This is a purely ordinal method that may sometimes lead to counterintuitive appraisals, in that it discards all information about the distance between the raw values within a given context. By contrast, this information is partly preserved by using standardization, i.e., by transforming the absolute values in such a way that, within the s…
Analysis of B-2-C Social Media Communication in Germany
2018
In this research paper, social media marketing activities of social media accounts from German business are analyzed for the social networks Facebook, Twitter, Instagram, Xing and LinkedIn. As research objects were the context of the interaction, the used and targeted social network functionalities and the behavior of the companies selected. The selection of social media accounts for the research included companies which are currently member from the stock market indices DAX and MDAX, additional online and offline retail business, successful German sports clubs, celebrities and others businesses. Also and to be sure to evaluate high-class social media marketing, the German social media awar…
Integrating Telemedicine Solutions with Electronic Health Records; Evaluation of Alternatives based on the Proposed Reference Architecture for Norway…
2016
This report studies the way forward for how a telemedicine solution can be integrated for exchange of data with an existing Electronic Health Record (EHR) system. The solution used an example for this report is based on a telemedicine solution for COPD patients (Chronic Obstructive Pulmonary Disease) developed in the project “Collaborative Point-of-Care Services Agder: Follow-up of COPD patients as part of the United4Health EU Project», with financial support from the Research Council of Norway. In addition, the EHR solution from DIPS ASA is used as an example of an existing system for integration. Important parameters for choosing way forward on how to are: urgency with regards to timeli…
Methodology in specimen fabrication for in vitro dental studies: Standardization of extracted tooth preparation
2017
Background Specimen preparation for in vitro study suffers a general lack of methodological homogeneity, as well as a lack of uniformity in the materials selected for fabricating them. This situation prevents comparisons between studies. When a specimen is not of dental origin it is not possible to study adhesion or bonding techniques realistically. The objective is to design and implement a method of specimen preparation that permits universal standardization for use in in vitro studies. Material and Methods A metal stump of specified dimensions was designed and fabricated by hand. It was scanned, the data digitalized, perfecting and standardizing the dimensions. Ten human molars were adap…