Search results for "State Model"
showing 9 items of 19 documents
State Space-Vector Model of Linear Induction Motors Including Iron Losses: Part II: Model Identification and Results
2018
This is the second part of a paper, divided into two parts, dealing with the definition of a space-vector dynamic model of the linear Induction motor (LIM) taking into consideration both the dynamic end-effects and the iron losses as well as the off-line identification of its parameters. The first part has treated the theoretical framework of the model. This second part is devoted to the description of an identification technique which has been suitably developed for the estimation of the parameters of the LIM dynamic model accounting for both the dynamic end-effects and iron losses, described in the first part of the paper. Such an identification technique is strictly related to the state …
Non-Equilibrium Markov State Modeling of the Globule-Stretch Transition
2016
We describe a systematic approach to construct coarse-grained Markov state models from molecular dynamics data of systems driven into a nonequilibrium steady state. We apply this method to study the globule-stretch transition of a single tethered model polymer in shear flow. The folding and unfolding rates of the coarse-grained model agree with the original detailed model. We demonstrate that the folding and unfolding proceeds through the same narrow region of configuration space but along different cycles.
Unfolding dynamics of small peptides biased by constant mechanical forces
2018
We show how multi-ensemble Markov state models can be combined with constant-force equilibrium simulations. Besides obtaining the unfolding/folding rates, Markov state models allow gaining detailed insights into the folding dynamics and pathways through identifying folding intermediates and misfolded structures. For two specific peptides, we demonstrate that the end-to-end distance is an insufficient reaction coordinate. This problem is alleviated through constructing models with multiple collective variables, for which we employ the time-lagged independent component analysis requiring only minimal prior knowledge. Our results show that combining Markov state models with constant-force simu…
A weighted combined effect measure for the analysis of a composite time-to-first-event endpoint with components of different clinical relevance
2018
Composite endpoints combine several events within a single variable, which increases the number of expected events and is thereby meant to increase the power. However, the interpretation of results can be difficult as the observed effect for the composite does not necessarily reflect the effects for the components, which may be of different magnitude or even point in adverse directions. Moreover, in clinical applications, the event types are often of different clinical relevance, which also complicates the interpretation of the composite effect. The common effect measure for composite endpoints is the all-cause hazard ratio, which gives equal weight to all events irrespective of their type …
Bayesian analysis of a disability model for lung cancer survival
2016
Bayesian reasoning, survival analysis and multi-state models are used to assess survival times for Stage IV non-small-cell lung cancer patients and the evolution of the disease over time. Bayesian estimation is done using minimum informative priors for the Weibull regression survival model, leading to an automatic inferential procedure. Markov chain Monte Carlo methods have been used for approximating posterior distributions and the Bayesian information criterion has been considered for covariate selection. In particular, the posterior distribution of the transition probabilities, resulting from the multi-state model, constitutes a very interesting tool which could be useful to help oncolog…
Le due crisi: crisi del capitalismo e crisi ambientale. Una soluzione sostenibile? (parte II)
2016
Vista nella Parte I la gravità della crisi ambientale, soprattutto l’instabilità climatica che caratterizzerà le prossime decadi, nella parte II si esplicitano le ragioni profonde della necessità di cambiare, e come, il modello di sviluppo. Negli ultimi quarant’anni la crisi ecologica non è mai diventata una variabile importante nelle politiche economiche. Colpa del neo-liberismo imperante, dall’ “unilateralismo” dell’amministrazione USA al “fiscal compact” della UE? Sì, ma anche le altre scuole economiche commettono lo stesso errore. L’attuale crisi del capitalismo è una crisi di sovrapproduzione, il cui carattere quantitativo, dovuto all’innovazione tecnologica nel mercato globalizzato, r…
Emotional user experience and feeling of control
2015
Current research on emotional user experience lacks a clear exposition on the relationship between feeling of control and the emotion response. The appraisal theory of emotion posits that perceived control over an event is an important factor in determining the emotional response to the event. It is therefore hypothesised, that the relationship between emotional experiences and interaction events is mediated by feeling of control. In an experiment (N = 38), participants used a joystick to control game objects, and gave self-reports of their emotional states and feeling of control. Pathway analyses predicting the factors of emotional experience with event logs reveal that feeling of control …
Comparisons, Categories, and Labels: Investigating the North–South Dichotomy in Europe
2021
The paper presents genealogy-oriented analysis of how the Nordic model gained its dominant characterization as modern, advanced and superior to other European welfare models while Southern European countries came to be labelled laggards in the welfare domain. To illuminate the relational nature of these, and all, comparisons, the analysis accentuates how researchers, politicians, and civil servants alike designate Nordic and Southern European states, their societies, and their welfare models. The empirical analysis focuses on scholarly writings about welfare-state comparisons (1986–2017) and on European Union documents addressing cohesion policies (1986–2021). Analysis of the vocabulary and…
Stability of social support during school transitions: Associations with truancy and not completing upper secondary education in normative time
2022
Not completing upper secondary education is often presignaled by truancy from school. Student-perceived social support from family, peers, and teachers can prevent truancy and the risk of not completing education. However, prior studies have not focused on the stability of social support across school transitions. This longitudinal study of 1901 Finnish students examined the extent to which social support was stable or specific to primary, lower secondary, and upper secondary schools. Moreover, we examined whether support was associated with not completing upper secondary education in normative time and whether truancy mediated the relationship between support and not completing education. …