Search results for "Static"
showing 8 items of 1528 documents
Safety and immunogenicity of the PRAME cancer immunotherapeutic in metastatic melanoma: results of a phase I dose escalation study
2016
Purpose The PRAME tumour antigen is expressed in several tumour types but in few normal adult tissues. A dose-escalation phase I/II study (NCT01149343) assessed the safety, immunogenicity and clinical activity of the PRAME immunotherapeutic (recombinant PRAME protein (recPRAME) with the AS15 immunostimulant) in patients with advanced melanoma. Here, we report the phase I dose-escalation study segment. Patients and methods Patients with stage IV PRAME-positive melanoma were enrolled to 3 consecutive cohorts to receive up to 24 intramuscular injections of the PRAME immunotherapeutic. The RecPRAME dose was 20, 100 or 500 µg in cohorts 1, 2 and 3, respectively, with a fixed dose of AS15. Advers…
Serenoa repens, lycopene and selenium versus tamsulosin for the treatment of LUTS/BPH. An Italian multicenter double-blinded randomized study between…
2014
Towards controlling PCDD/F production in a multi-fuel fired BFB boiler using two sulfur addition strategies
2014
Abstract PCDD/F abatement strategies – sulfur pellet addition and peat co-combustion – were tested for a BFB boiler facility utilizing SRF-bark-sludge as fuel. In this paper chemical and physical analyses of electrostatic precipitator (ESP) fly ashes were used to explain the differences in the performance of these strategies. These analyses revealed a difference between the coarse and fine fly ashes collected in the ESP. Chemical analysis of the fine fly ashes revealed high concentration of easily volatilized elements while the SEM micrographs showed that fine ash are composed of clusters of spherical particles, thereby leading to a conclusion that fine ashes were originally in a gas phase …
Automatic SCSB analysis of motor and autonomic nervous activity in infants compared to EEG-based sleep stages
2002
Kinematic and Elastostatic Design Optimisation of the 3-DOF Gantry-Tau Parallel Kinematic Manipulator
2009
Published version of an article in the journal: Modeling Identification and Control. Also available from the publisher:http://dx.doi.org/10.4173/mic.2009.2.1 One of the main advantages of the Gantry-Tau machine is a large accessible workspace/footprint ratio compared to many other parallel machines. The Gantry-Tau improves this ration further by allowing a change of assembly mode without internal link collisions or collisions between the links and end-effector. The reconfigurable Gantry-Tau kinematic design obtained by multi-objective optimisation according to this paper gives the following features: 3-D workspace/footprint ration is more than 3.19, lowest Cartesian stiffness in the workspa…
Prostatic adenocarcinoma with mandibular metastatic lesion : case report
2007
Metastatic lesions of primary tumors, which originate in different parts of the body, comprise almost 1 % of different types of oral cancers. These lesions can affect either bones or soft tissues in the maxillofacial region. Whenever the maxillofacial area is affected, the most common location is in the molar region of the mandible. The clinical presentation of mandibular metastasis follows a clinical pattern characterized by irradiated dental pain in the third molar region. The most frequent sign is parethesia of the area innervated by the mandibular alveolar dental nerve. Differential diagnosis and treatment of these patients can be extremely difficult because there a number of pathologic…