Search results for "Statistica"

Hierarchical modeling for rare event detection and cell subset alignment across flow cytometry samples.

2013

Flow cytometry is the prototypical assay for multi-parameter single cell analysis, and is essential in vaccine and biomarker research for the enumeration of antigen-specific lymphocytes that are often found in extremely low frequencies (0.1% or less). Standard analysis of flow cytometry data relies on visual identification of cell subsets by experts, a process that is subjective and often difficult to reproduce. An alternative and more objective approach is the use of statistical models to identify cell subsets of interest in an automated fashion. Two specific challenges for automated analysis are to detect extremely low frequency event subsets without biasing the estimate by pre-processing…

Compression-based classification of biological sequences and structures via the Universal Similarity Metric: experimental assessment.

2007

Abstract Background Similarity of sequences is a key mathematical notion for Classification and Phylogenetic studies in Biology. It is currently primarily handled using alignments. However, the alignment methods seem inadequate for post-genomic studies since they do not scale well with data set size and they seem to be confined only to genomic and proteomic sequences. Therefore, alignment-free similarity measures are actively pursued. Among those, USM (Universal Similarity Metric) has gained prominence. It is based on the deep theory of Kolmogorov Complexity and universality is its most novel striking feature. Since it can only be approximated via data compression, USM is a methodology rath…

Guest Editors' Introduction to the Special Section on Algorithms in Bioinformatics

2008

Modelling and Analysis of Non-Stationary Multipath Fading Channels with Time-Variant Angles of Arrival

2017

In mobile radio channel modelling, it is generally assumed that the angles of arrival (AOAs) are independent of time. This assumption does in general not agree with real-world channels in which the AOAs vary with the position of a moving receiver. In this paper, we first present a mathematical model for the time-variant AOAs. This model serves as the basis for the development of two non-stationary multipath fading channels models. The statistical properties of both channel models are analysed with emphasis on the time-dependent autocorrelation function (ACF), time-dependent mean Doppler shift, time-dependent Doppler spread, and the Wigner-Ville spectrum. It is shown that these characteristi…

Efficient linear fusion of partial estimators

2018

Abstract Many signal processing applications require performing statistical inference on large datasets, where computational and/or memory restrictions become an issue. In this big data setting, computing an exact global centralized estimator is often either unfeasible or impractical. Hence, several authors have considered distributed inference approaches, where the data are divided among multiple workers (cores, machines or a combination of both). The computations are then performed in parallel and the resulting partial estimators are finally combined to approximate the intractable global estimator. In this paper, we focus on the scenario where no communication exists among the workers, de…

Influence Diagnostics for Meta-Analysis of Individual Patient Data Using Generalized Linear Mixed Models

2014

In meta-analysis, generalized linear mixed models (GLMMs) are usually used when heterogeneity is present and individual patient data (IPD) are available, while accepting binary, discrete as well as continuous response variables. In the present paper some measures of influence diagnostics based on log-likelihood are suggested and discussed. A known measure is approximated to get a simpler form, for which the information matrix is no more necessary. The performance of the proposed measure is assessed through a diagnostic analysis on simulated data reproducing a possible meta-analytical context of IPD with influential outliers. The proposed measure is showed to work well and to have a form sim…

Applicability of the Poisson distribution to model the data of the German Children's Cancer Registry.

1995

Since 1980 the German Children's Cancer Registry has documented all childhood malignancies in the Federal Republic of Germany. Various statistical procedures have been proposed to identify municipalities or other geographic units with increased numbers of malignancies. Usually the Poisson distribution, which requires the malignancies to be distributed homogeneously and uncorrelated, is applied. Other discrete statistical distributions (so-called cluster distributions) like the generalized or compound Poisson distributions are applicable more generally. In this paper we present a first explorative approach to the question of whether it is necessary to use one of these cluster distributions t…

Power estimation for non-standardized multisite studies

2016

A concern for researchers planning multisite studies is that scanner and T1-weighted sequence-related biases on regional volumes could overshadow true effects, especially for studies with a heterogeneous set of scanners and sequences. Current approaches attempt to harmonize data by standardizing hardware, pulse sequences, and protocols, or by calibrating across sites using phantom-based corrections to ensure the same raw image intensities. We propose to avoid harmonization and phantom-based correction entirely. We hypothesized that the bias of estimated regional volumes is scaled between sites due to the contrast and gradient distortion differences between scanners and sequences. Given this…

Geometrical Modeling of Non-Stationary Polarimetric Vehicular Radio Channels

2019

This paper presents a geometry-based statistical model (GBSM) of polarimetric wideband multipath radio channels for vehicle-to-vehicle (V2V) communications. The proposed model captures the effects of depolarization caused by multipath propagation, and it also accounts for the non-stationary characteristics of wideband V2V channels. This is a novel feature, because the existing polarimetric channel models are built on the assumption that the channel is a wide-sense stationary random process. In the modeling framework described in this paper, the channel depolarization function is given by a linear transformation in the form of a simple rotation matrix. This linear transformation is transpare…

Methodological considerations for interrupted time series analysis in radiation epidemiology: an overview

2021

Interrupted time series analysis (ITSA) is a method that can be applied to evaluate health outcomes in populations exposed to ionizing radiation following major radiological events. Using aggregated time series data, ITSA evaluates whether the time trend of a health indicator shows a change associated with the radiological event. That is, ITSA checks whether there is a statistically significant discrepancy between the projection of a pre-event trend and the data empirically observed after the event. Conducting ITSA requires one to consider specific methodological issues due to unique threats to internal validity that make ITSA prone to bias. We here discuss the strengths and limitations of …