Search results for "Statistical Model"
showing 10 items of 163 documents
How to deal with Haplotype data: An Extension to the Conceptual Schema of the Human Genome
2016
[EN] The goal of this work is to describe the advantages of the application of Conceptual Modeling (CM) in complex domains, such as genomics. Nowadays, the study and comprehension of the human genome is a major challenge due to its high level of complexity. The constant evolution in the genomic domain contributes to the generation of ever larger amounts of new data, which means that if we do not manage it correctly data quality could be compromised (i.e., problems related with heterogeneity and inconsistent data). In this paper, we propose the use of a Conceptual Schema of the Human Genome (CSHG), designed to understand and improve our ontological commitment to the domain and also extend (e…
Investigation of the consequences of the modifiable areal unit problem in macroscopic traffic safety analysis: A case study accounting for scale and …
2019
Abstract Traffic safety analysis at the macroscopic level usually relies on previously defined areal traffic analysis zones (TAZs) that are used as the units of investigation. Hence, statistical inference is made on the basis of such units, implying that the consideration of a certain TAZ configuration may influence the results and conclusions achieved. Regarding this, the modifiable areal unit problem (MAUP) is a well-known issue in the field of spatial statistics, which refers to the effects that arise in statistical properties and estimations when there is a change in areal units of analysis. In this paper, the consequences of MAUP have been investigated through a dataset of traffic cras…
Development and application of Bayesian dynamic compartment modelling to study labour (in)stability in Spain
2022
Esta es una tesis metodológica en la que nos centramos en el mercado laboral. Sin embargo, los métodos aquí desarrollados también podrían aplicarse a otras áreas de las Ciencias Sociales permitiendo a los/las investigadores/investigadoras ampliar el conocimiento al abordar las preguntas de investigación desde un punto de vista diferente. En este contexto, la (in)estabilidad laboral podría entenderse como la velocidad de transición del empleo al no empleo y viceversa. Si la velocidad es alta, la inestabilidad también es alta; por el contrario, si la velocidad de transición es baja, habrá una baja inestabilidad. El objetivo principal de esta tesis es desarrollar un nuevo marco metodológico pa…
Optical factors influencing the amplitude of accommodation
2017
AbstractThe purpose of this work was to find plausible predictors among optical parameters that may explain the inter-individual differences in subjective amplitude of accommodation not explained by age. An exploratory multivariable regression analysis was carried out retrospectively on a dataset with 180 eyes from 97 subjects (ages ranged from 20 to 58years). Subjective amplitudes of accommodation were recorded with the use of a custom-made Badal system. A commercial aberrometer was used to obtain each eye’s wavefront during the full range of accommodation. The plausible predictors under study were pupil diameter in the unaccommodated eye, its reduction with accommodation; fourth- and six-…
Design Issues and Sample Size when Exposure Measurement is Inaccurate
2001
AbstractMeasurement error often leads to biased estimates and incorrect tests in epidemiological studies. These problems can be corrected by design modifications which allow for refined statistical models, or in some situations by adjusted sample sizes to compensate a power reduction. The design options are mainly an additional replication or internal validation study. Sample size calculations for these designs are more complex, since usually there is no unique design solution to obtain a prespecified power. Thus, additionally to a power requirement, an optimal design should also fulfill the criteria of minimizing overall costs. In this review corresponding strategies and formulae are descr…
QuBiLs-MAS method in early drug discovery and rational drug identification of antifungal agents
2015
The QuBiLs-MAS approach is used for the in silico modelling of the antifungal activity of organic molecules. To this effect, non-stochastic (NS) and simple-stochastic (SS) atom-based quadratic indices are used to codify chemical information for a comprehensive dataset of 2478 compounds having a great structural variability, with 1087 of them being antifungal agents, covering the broadest antifungal mechanisms of action known so far. The NS and SS index-based antifungal activity classification models obtained using linear discriminant analysis (LDA) yield correct classification percentages of 90.73% and 92.47%, respectively, for the training set. Additionally, these models are able to correc…
Environmental drivers and abrupt changes of phytoplankton community in temperate lake Lielais Svētiņu, Eastern Latvia, over the last Post-Glacial per…
2021
Understanding the long-term dynamics of ecological communities on the centuries-to-millennia scale is important for explaining the emergence of present-day biodiversity patterns and for predicting possible future scenarios. Fossil pigments and ancient DNA present in various sedimentary deposits can be analysed to study long-term changes in ecological communities. We analysed recent compilations of data, including fossil pigments, microfossils, and molecular inventories from the sedimentary archives, to understand the impact of gradual versus abrupt climate changes on the ecosystem status of a regional model lake over the last ~14.5 kyr. Such long and complete paleo-archives are scarce in No…
Statistical modeling, simulation, and experimental verification of wideband indoor mobile radio channel
2018
This paper focuses on the modeling, simulation, and experimental verification of wideband single-input single-output (SISO) mobile fading channels for indoor propagation environments. The indoor reference channel model is derived from a geometrical rectangle scattering model, which consists of an infinite number of scatterers. It is assumed that the scatterers are exponentially distributed over the two-dimensional (2D) horizontal plane of a rectangular room. Analytical expressions are derived for the probability density function (PDF) of the angle of arrival (AOA), the PDF of the propagation path length, the power delay profile (PDP), and the frequency correlation function (FCF). An efficie…
Estimation of sub-hourly DDF curves using scaling properties of hourly and sub-hourly data at partially gauged site
2005
Abstract In urban drainage systems, knowledge of short-duration rainfall events can be considered as one of the most critical elements when their hydrological behaviour wants to be investigated. The temporal resolution of rainfall data usually available for practical applications is often lower than the data requested for the design procedures or mathematical models application, greatly affecting their reliability. Moreover, when high resolution rain gauges are available in the catchment, the registration period cannot be sufficiently long for obtaining practically usable statistical analyses. The present study proposes a method for estimating the distribution of sub-hourly extreme rainfall…
Relationship between the effective cloud optical depth and different atmospheric transmission factors
2015
This study examines the sensitivity of cloud optical depth (COD) for overcast conditions to radiation transmission using data collected in Valencia, Spain. These relationships are provided as simple empirical functions, therefore avoiding the need to apply complex model minimisation schemes to obtain COD. Comparisons are presented between COD obtained by a minimization method and several radiation transmission factors comprising a clearness index (kt), a modified version (kt'), a cloud modification factor (CMF) and its modified version (CMF'). Additionally, a statistical model of COD proposed by J.C. Barnard and C.N. Long (2004) is tested with our data. Statistical relationships between COD…