Search results for "Statistical"
showing 10 items of 4960 documents
Prenatal exposure to organochlorine compounds and lung function during childhood
2019
Introduction: Prenatal exposure to organochlorine compounds (OCs) can increase the risk of reported respiratory symptoms in children. It remains unclear whether these compounds can also impact on lung function. We assessed the association between prenatal exposure to OCs and lung function during childhood. Methods: We included 1308 mother-child pairs enrolled in a prospective cohort study. Prenatal concentrations of p,p′-dichlorodiphenyltrichloroethane [p,p′-DDT], p,p′-dichlorodiphenyldichloroethylene [p,p′-DDE], hexachlorobenzene [HCB], and seven polychlorinated biphenyls [PCBs] were measured in cord blood. Spirometry was performed in the offspring at ages 4 (n = 636) and 7 years (n = 1192…
A model-based approach for assessing bronchodilator responsiveness in children: The conventional cutoff revisited
2020
An increase in FEV1 >=12% has been proposed in international guidelines as a clue to airway reversibility for diagnosing asthma in both adults and children. However, the validity of this cut-off has been questioned in the pediatric population. The aim of this study was to provide evidence that different cut-off values in BDR may be associated with better performance in discriminating among outpatient children with naïve asthma (A) and without asthma (NA). We compared three approaches: i) the conventional cutoff (12%); ii) the cut-off estimated by Youden's criteria; and iii) the cut-off based on a model-driven approach. we found that the conventional cut-off of 12% showed poor sensitivity in…
Measuring lung function in asthmatic children: A spirometry and forced oscillation technique (FOT) comparison
2016
Background: Spirometry is the most common pulmonary function test used in asthma diagnosing. However, it requires good patient co-operation. FOT has gained increasing attention for the measurement of pulmonary function in children because it is performed at steady state breathing. Aim: To compare spirometry and FOT in order to discriminate severity of asthma according to GINA. Methods: Spirometry and FOT were performed in 176 out-patient asthmatic children (5-16 year), 100 (57%) with naive Persistent Asthma (PA) and 76 (43%) with Intermittent Asthma (IA), consecutively enrolled at the IBIM pediatric clinic. Two principal component analyses (PCA) were performed, the first (PCA1) based on FEV…
More wavelet-like orthonormal bases for the lowest Landau level: Some considerations
1994
In a previous work, Antoine and I (1994) have discussed a general procedure which 'projects' arbitrary orthonormal bases of L2(R) into orthonormal bases of the lowest Landau level. In this paper, we apply this procedure to a certain number of examples, with particular attention to the spline bases. We also discuss Haar, Littlewood-Paley and Journe bases.
Tabula 0.3 beta
2010
The final aim of the majority of statistical analyses is to create a set of statistical tables for publication. Generally complex statistical survey reports contain a lot of tables which usually have more than two entries. In order to create tables like these, you have first to run a lot of Stata commands and to write them by hand. This process is error prone and it’s difficult to create tables with more than four entries using ordinary Stata commands. Tabula is not a Stata command but a complete software written in C++, with a user-friendly GUI. The main aims of Tabula are to automate the production of reports and to minimize human errors. It allows you to create your statistical table thr…
Non-Equilibrium Markov State Modeling of the Globule-Stretch Transition
2016
We describe a systematic approach to construct coarse-grained Markov state models from molecular dynamics data of systems driven into a nonequilibrium steady state. We apply this method to study the globule-stretch transition of a single tethered model polymer in shear flow. The folding and unfolding rates of the coarse-grained model agree with the original detailed model. We demonstrate that the folding and unfolding proceeds through the same narrow region of configuration space but along different cycles.
Unfolding dynamics of small peptides biased by constant mechanical forces
2018
We show how multi-ensemble Markov state models can be combined with constant-force equilibrium simulations. Besides obtaining the unfolding/folding rates, Markov state models allow gaining detailed insights into the folding dynamics and pathways through identifying folding intermediates and misfolded structures. For two specific peptides, we demonstrate that the end-to-end distance is an insufficient reaction coordinate. This problem is alleviated through constructing models with multiple collective variables, for which we employ the time-lagged independent component analysis requiring only minimal prior knowledge. Our results show that combining Markov state models with constant-force simu…
Separatrix reconstruction to identify tipping points in an eco-epidemiological model
2018
Many ecological systems exhibit tipping points such that they suddenly shift from one state to another. These shifts can be devastating from an ecological point of view, and additionally have severe implications for the socio-economic system. They can be caused by overcritical perturbations of the state variables such as external shocks, disease emergence, or species removal. It is therefore important to be able to quantify the tipping points. Here we present a study of the tipping points by considering the basins of attraction of the stable equilibrium points. We address the question of finding the tipping points that lie on the separatrix surface, which partitions the space of system traj…
Time delay induced effects on control of linear systems under random excitation
2001
Recursive formulas in terms of statistics of the response of linear systems with time delay under normal white noise input are developed. Two alternative methods are presented, in order to capture the time delay effects. The first is given in an approximate solution obtained by expanding the control force in a Taylor series. The second, available for the stationary solution (if it exists) gets the variance of the controlled system, with time delay in an analytical form. The efficacy loss in terms of statistics of the response is discussed in detail.
Statistical correlation of fractional oscillator response by complex spectral moments and state variable expansion
2016
Abstract The statistical characterization of the oscillator response with non-integer order damping under Gaussian noise represents an important challenge in the modern stochastic mechanics. In fact, this kind of problem appears in several issues of different type (wave propagation in viscoelastic media, Brownian motion, fluid dynamics, RLC circuit, etc.). The aim of this paper is to provide a stochastic characterization of the stationary response of linear fractional oscillator forced by normal white noise. In particular, this paper shows a new method to obtain the correlation function by exact complex spectral moments. These complex quantities contain all the information to describe the r…