Search results for "Stifle"

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Regulation of the inflammatory response by tin protoporphyrin IX in the rat anterior cruciate ligament transection model of osteoarthritis

2010

The purpose of this study was to investigate several inflammatory mediators and cartilage degradation molecules as possible biomarkers of joint lesion in the anterior cruciate ligament transection (ACLT) model of osteoarthritis in rats. We also assessed whether the treatment with the anti-inflammatory agent tin protoporphyrin IX (SnPP) reduces the progression of disease. Our results indicate that serum levels of interleukin (IL)-6 and PGE2 are significantly increased in ACLT rats 10 weeks after surgery, whereas the increases in IL-1β and tumor necrosis-α were not significant. In addition, our data suggest that IL-17 is the main pro-inflammatory cytokine in the ACLT joint. We have shown that…

Cartilage ArticularMalemedicine.medical_specialtyMetalloporphyrinsAnterior cruciate ligamentType II collagenProtoporphyrinsInflammationOsteoarthritisDinoprostoneLesionchemistry.chemical_compoundInternal medicineOsteoarthritisHyaluronic acidmedicineAnimalsOrthopedics and Sports MedicineAnterior Cruciate LigamentEnzyme InhibitorsRats WistarCartilage oligomeric matrix proteinbiologybusiness.industryAnterior Cruciate Ligament InjuriesCartilageAnti-Inflammatory Agents Non-Steroidalmedicine.diseaseStifleRatsSurgeryDisease Models AnimalEndocrinologymedicine.anatomical_structurechemistrybiology.proteinCytokinesmedicine.symptombusinessBiomarkersJournal of Orthopaedic Research

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PEPhysical Sciences and Engineering
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LSLife Sciences
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SHSocial Sciences and Humanities
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