Search results for "Subdominant"
showing 6 items of 6 documents
Immunodominant Cytomegalovirus Epitopes Suppress Subdominant Epitopes in the Generation of High-Avidity CD8 T Cells
2021
CD8+ T-cell responses to pathogens are directed against infected cells that present pathogen-encoded peptides on MHC class-I molecules. Although natural responses are polyclonal, the spectrum of peptides that qualify for epitopes is remarkably small even for pathogens with high coding capacity. Among those few that are successful at all, a hierarchy exists in the magnitude of the response that they elicit in terms of numbers of CD8+ T cells generated. This led to a classification into immunodominant and non-immunodominant or subordinate epitopes, IDEs and non-IDEs, respectively. IDEs are favored in the design of vaccines and are chosen for CD8+ T-cell immunotherapy. Using murine cytomegalov…
Processing of Musical Syntax Tonic versus Subdominant: An Event-related Potential Study
2006
Abstract The present study investigates the effect of a change in syntactic-like musical function on event-related brain potentials (ERPs). Eight-chord piano sequences were presented to musically expert and novice listeners. Instructed to watch a movie and to ignore the musical sequences, the participants had to react when a chord was played with a different instrument than the piano. Participants were not informed that the relevant manipulation was the musical function of the last chord (target) of the sequences. The target chord acted either as a syntactically stable tonic chord (i.e., a C major chord in the key of C major) or as a less syntactically stable subdominant chord (i.e., a C ma…
Further Investigation of Harmonic Priming in Long Contexts Using Musical Timbre as Surface Marker to Control for Temporal Effects
2004
Harmonic priming studies have reported facilitated processing for chords that are harmonically related to the prime context. Responses to the target (the last chord of an 8-chord sequence) were faster and more accurate when the target was strongly related, i.e., a tonic chord, to the preceding prime context than when it was less related, i.e., a subdominant chord. Results have been interpreted in terms of musical expectations and processing speed: the prime allows listeners to develop expectations for future events which lead to facilitated processing of the most strongly expected event. The present experiment investigated an alternative hypothesis suggesting that the harmonic structure of…
Priming paradigm reveals harmonic structure processing in congenital amusia.
2012
Abstract Deficits for pitch structure processing in congenital amusia has been mostly reported for melodic stimuli and explicit judgments. The present study investigated congenital amusia with harmonic stimuli and a priming task. Amusic and control participants performed a speeded phoneme discrimination task on sung chord sequences. The target phoneme was sung either on a functionally important chord (tonic chord, referred to as “related target”) or a less important one (subdominant chord, referred to as “less-related target”). Correct response times were faster when the target phoneme was sung on tonic chords rather than on subdominant chords, and this effect was less pronounced, albeit si…
The influence of task-irrelevant music on language processing: syntactic and semantic structures.
2011
Recent research has suggested that music and language processing share neural resources, leading to new hypotheses about interference in the simultaneous processing of these two structures. The present study investigated the effect of a musical chord's tonal function on syntactic processing (Experiment 1) and semantic processing (Experiment 2) using a cross-modal paradigm and controlling for acoustic differences. Participants read sentences and performed a lexical decision task on the last word, which was, syntactically or semantically, expected or unexpected. The simultaneously presented (task-irrelevant) musical sequences ended on either an expected tonic or a less-expected subdominant ch…
The effect of harmonic context on phoneme monitoring in vocal music
2001
The processing of a target chord depends on the previous musical context in which it has appeared. This harmonic priming effect occurs for fine syntactic-like changes in context and is observed irrespective of the extent of participants' musical expertise (Bigand & Pineau, Perception and Psychophysics, 59 (1997) 1098). The present study investigates how the harmonic context influences the processing of phonemes in vocal music. Eight-chord sequences were presented to participants. The four notes of each chord were played with synthetic phonemes and participants were required to quickly decide whether the last chord (the target) was sung on a syllable containing the phoneme /i/ or /u/. The mu…