Search results for "Suberitine"

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Differential Expression of the Demosponge (Suberites domuncula) Carotenoid Oxygenases in Response to Light: Protection Mechanism Against the Self-Pro…

2012

The demosponge Suberites domuncula has been described to contain high levels of a proteinaceous toxin, Suberitine, that displays haemolytic activityIn the present study this 7–8 kDa polypeptide has been isolated and was shown to exhibit also cytotoxic effects on cells of the same species. Addition of retinal, a recently identified metabolite of β-carotene that is abundantly present in S. domuncula was found to reduce both the haemolytic and the cell toxic activity of Suberitine at a molar ratio of 1:1. Spectroscopic analyses revealed that the interaction between β-carotene and Suberitine can be ascribed to a reversible energy transfer reaction. The enzyme that synthesises retinal in the spo…

OxygenaseLightMolecular Sequence DataPharmaceutical Sciencemedicine.disease_causeretinalArticle03 medical and health sciencesSuberitineDioxygenaseβ-caroteneDrug DiscoverymedicineAnimalsAmino Acid SequenceCloning Molecularlcsh:QH301-705.5Pharmacology Toxicology and Pharmaceutics (miscellaneous)Carotenoidsponges030304 developmental biologyβ-carotene dioxygenasechemistry.chemical_classification0303 health sciencesbiologyBacteriaToxinCarotenoid oxygenase030302 biochemistry & molecular biologyProteinsSuberitine; β-carotene; retinal; β-carotene dioxygenase; sponges; <em>Suberites domuncula</em>biology.organism_classificationSuberites domunculaSuberites domunculaEnzymelcsh:Biology (General)Biochemistrychemistrybiology.proteinOxygenasesRetinaldehydeSuberitesSuberitesMarine Drugs

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