Search results for "Substance"
showing 10 items of 1728 documents
Evaluation of the antibacterial power and biocompatibility of zinc oxide nanorods decorated graphene nanoplatelets: New perspectives for antibiodeter…
2017
Background Nanotechnologies are currently revolutionizing the world around us, improving the quality of our lives thanks to a multitude of applications in several areas including the environmental preservation, with the biodeterioration phenomenon representing one of the major concerns. Results In this study, an innovative nanomaterial consisting of graphene nanoplatelets decorated by zinc oxide nanorods (ZNGs) was tested for the ability to inhibit two different pathogens belonging to bacterial genera frequently associated with nosocomial infections as well as biodeterioration phenomenon: the Gram-positive Staphylococcus aureus and the Gram-negative Pseudomonas aeruginosa. A time- and dose-…
Pharmacological activation of CB2 receptors counteracts the deleterious effect of ethanol on cell proliferation in the main neurogenic zones of the a…
2015
Chronic alcohol exposure reduces endocannabinoid activity and disrupts adult neurogenesis in rodents, which results in structural and functional alterations. Cannabinoid receptor agonists promote adult neural progenitor cell (NPC) proliferation. We evaluated the protective effects of the selective CB1 receptor agonist ACEA, the selective CB2 receptor agonist JWH133 and the fatty-acid amide-hydrolase (FAAH) inhibitor URB597, which enhances endocannabinoid receptor activity, on NPC proliferation in rats with forced consumption of ethanol (10%) or sucrose liquid diets for 2 weeks. We performed immunohistochemical and stereological analyses of cells expressing the mitotic phosphorylation of his…
Diagnostic utility of new short versions of AUDIT to detect binge drinking in undergraduate students
2021
ABSTRACT This study examines the usefulness of two AUDIT adaptations with a sample of 907 undergraduate alcohol users. On the one hand, it includes the AR2i that encompasses revised A2r and A3r consumption items, and on the other hand—in addition to the two former items—the inclusion of items 4, 8, and 9, which evaluate consequences. The results indicate that both adaptations identify BD more precisely than the traditional scales (AUDIT and AUDIT-C), but the usefulness of each will depend on the clinical purpose they are given. In environments where time is a key factor in detecting high-risk consumption it will be more appropriate to use AR2i, which evaluates the pattern of con…
El consumo de sustancias psicoactivas en la adolescencia temprana y media. El papel de la eficacia académica y de la crianza
2020
ABSTRACT This study examines (i) the relationships between substance use and parenting style and between substance use and perceived academic self-efficacy in early and middle adolescence, (ii) the importance of these factors in predicting adolescent substance use, and (iii) the role of academic self-efficacy in the relationship between parenting styles and adolescent substance use. The sample comprised 762 adolescents (53% boys) aged 12 to 16 years (M = 13.66, SD = 1.34). The sample was selected using probabilistic cluster sampling according to type of school (secondary, public vs. semi-private) and school location in different areas of the city of Valencia (Spain). This approach accounted…
Substance Use in Early and Middle Adolescence. The Role of Academic Efficacy and Parenting
2019
espanolLos objetivos de esta investigacion son analizar la relacion del consumo de sustancias con el estilo de crianza de los padres y la percepcion de eficacia academica por parte de los adolescentes, estudiar la diferente contribucion de estos factores a la prediccion del consumo de sustancias en la adolescencia y observar la funcion de la autoeficacia academica en la relacion entre el estilo de crianza y el consumo de sustancias en la adolescencia. Participaron 762 adolescentes (53% hombres), de edades comprendidas entre los 12 y los 16 anos (M = 13.66, DT = 1.34). La muestra se selecciono con criterios probabilisticos por conglomerados, atendiendo al tipo de centro (educacion secundaria…
Darstellung und polymerisation von diestern aus 2,2′-methylendiphenolen und acryl-, methacryl- bzw. Crotonsäure
1984
Several mono- and diesters of four selected 2,2′-methylenediphenols with acrylic, methacrylic, and crotonic acid were synthesized for the first time. Special emphasis was paid to the preparation of diesters with two different acyl groups which could be obtained via the corresponding monoesters. The radical polymerization of these esters with AIBN (mainly in benzene) gave insoluble (crosslinked) products from dimethacrylates and soluble (linear) polymers from mixed diesters with methacrylic and crotonic acid, while the dicrotonates are not reactive.
Red cell sorbitol concentration in relation to short- and medium-term variation of plasma glucose.
1989
To evaluate the time course of changes in red cell sorbitol (RCS) concentration in relation to variations of plasma glucose levels, RCS was determined in 7 normal subjects during i.v. glucose infusion (IVGTT); in 6 hyperglycemic insulin-dependent diabetic subjects while glycemia was normalized with Biostator GC 115 and in 4 diabetic patients in previously poor metabolic control, in whom normal glycemia was obtained in 8–10 days by intensive insulin therapy. During IVGTT, plasma glucose levels increased with significant differences from baseline at 5, 10, 16, 25, 60, 100 and 160 min and returned to basal levels after 3h; RCS concentration showed small and insignificant increases. During i.v.…
Binding of basic amphipathic peptides to neutral phospholipid membranes: a thermodynamic study applied to dansyl-labeled melittin and substance P ana…
1997
A thermodynamic approach is proposed to quantitatively analyze the binding isotherms of peptides to model membranes as a function of one adjustable parameter, the actual peptide charge in solution z(p)+. The main features of this approach are a theoretical expression for the partition coefficient calculated from the molar free energies of the peptide in the aqueous and lipid phases, an equation proposed by S. Stankowski [(1991) Biophysical Journal, Vol. 60, p. 341] to evaluate the activity coefficient of the peptide in the lipid phase, and the Debye-Huckel equation that quantifies the activity coefficient of the peptide in the aqueous phase. To assess the validity of this approach we have s…
Binding of a fluorescent dansylcadaverine-substance P analogue to negatively charged phospholipid membranes.
2000
Abstract We have investigated the binding of a new dansylcadaverine derivative of substance P (DNC-SP) with negatively charged small unilamellar vesicles composed of a mixture of phosphatidylcholine (PC) and either phosphatidylglycerol (PG) or phosphatidylserine (PS) using fluorescence spectroscopic techniques. The changes in fluorescence properties were used to obtain association isotherms at variable membrane negative charges and at different ionic strengths. The experimental association isotherms were analyzed using two binding approaches: (i) the Langmuir adsorption isotherm and the partition equilibrium model, that neglect the activity coefficients; and (ii) the partition equilibrium m…
Análisis de redes sociales y bibliométrico de las tesis españolas sobre drogodependencias en la base de datos TESEO
2018
The present study aims to reveal the structure of positions in the field of addiction through the analysis of doctoral theses read in Spain. The source consulted for the selection of the theses was TESEO. Searching for the keywords drug abuse, alcoholism, drug effects and drug addiction treatment during the period 1976-2017 produced 728 theses. The most productive period is 2013-2017, with 208 (28.6%) doctoral theses. The overall rate of publication is increasing, but in the period 2003-2007 output decreased significantly to 5.2% of the total. The university contributing the most theses is the University of Valencia. The academic who has supervised the most theses is Alfonso Velasco Martin,…