Search results for "Sud"

Beneficial effects of heme oxygenase-1 up-regulation in the development of experimental inflammation induced by zymosan.

2003

Heme oxygenase-1 (HO-1) is part of the integrated response to oxidative stress. This enzyme may exert anti-inflammatory effects in some animal models, although the precise mechanisms are not fully understood. We have examined the role of HO-1 in the inflammatory response induced by zymosan in the mouse air pouch. Zymosan administration induced HO-1 protein expression in leukocytes migrating to exudates, with maximal levels in the late phase of this response (24-48 h). This was accompanied by ferritin induction and bilirubin accumulation, indicating that this enzyme is active in our model. HO-1 expression by zymosan treatment was partly reduced by aminoguanidine, suggesting the participation…

Laimes un likteņa tēmas aktualizācija J. Jaunsudrabiņa garstāsta „Vēja ziedi'' apguvē 11. klasē

2021

Diplomdarba „Laimes un likteņa tēmas aktualizācija J. Jaunsudrabiņa garstāsta „Vēja ziedi” apguvē 11. klasē” mērķis ir izstrādāt literatūras stundas plānojumu laimes un likteņa tēmas aktualizācijai J. Jaunsudrabiņa garstāstā „Vēja ziedi” apguvē attālināto mācību procesā. Diplomdarbā ir 5 nodaļas. Pirmajā nodaļā analizēta laime un liktenis vārdnīcās un laime un liktenis J. Jaunsudrabiņa daiļdarbos „Aija”, „Vēja ziedi” un „Jaunsaimnieks un velns”. Otrajā nodaļā apskatīts Jāņa Jaunsudrabiņa dzīves gājums, daiļrades iezīmes. Trešajā nodaļā analizēts un apkopots literatūras kritiķu vērtējums par J. Jaunsudrabiņu un garstāstu „Vēja ziedi”. Ceturtajā nodaļā aprakstīta skolotājas sagatavošanās darb…

Poetic Language and the sign: a paradigm in contemporary China

2020

Lo studio esamina il rapporto tra scrittura poetica e pittura nella produzione dei poeti cinesi contemporanei molti dei quali praticano entrambe le forme d'arte. This work is about the connection between poetry writing and painting in contemporary Chinese poets, many of whom practice both forms of art.

Il responsabile politico di classe

2017

Traduzione dal cinese all'italiano

Verdadero caracter de Mahoma y de su religión : justa idea de este falso profeta, sin alabarle con exceso, ni deprimirle con odio ...

Sig. [ ]2, A-H4, I2; [ ]1, A-L4; [ ]1, A-H4; [ ]1, A-I4. - Obra composta per un Discurs preliminar amb pag. pròpia i una Primera, Segona i Tercera part amb pag. comú però amb port. pròpia cada part Notes a peu de p. - Reclams. - Bandes i filets

Natural selection mediated by seasonal time constraints increases the alignment between evolvability and developmental plasticity

2021

Abstract Phenotypic plasticity can either hinder or promote adaptation to novel environments. Recent studies that have quantified alignments between plasticity, genetic variation, and divergence propose that such alignments may reflect constraints that bias future evolutionary trajectories. Here, we emphasize that such alignments may themselves be a result of natural selection and do not necessarily indicate constraints on adaptation. We estimated developmental plasticity and broad sense genetic covariance matrices (G) among damselfly populations situated along a latitudinal gradient in Europe. Damselflies were reared at photoperiod treatments that simulated the seasonal time constraints ex…

KCND3 potassium channel gene variant confers susceptibility to electrocardiographic early repolarization pattern

2019

BACKGROUND: The presence of an early repolarization pattern (ERP) on the surface ECG is associated with risk of ventricular fibrillation and sudden cardiac death. Family studies have shown that ERP is a highly heritable trait, but molecular genetic determinants are unknown. METHODS: To identify genetic susceptibility loci for ERP, we performed a GWAS and meta-analysis in 2,181 cases and 23,641 controls of European ancestry. RESULTS: We identified a genome-wide significant (P < 5 × 10(–8)) locus in the potassium voltage-gated channel subfamily D member 3 (KCND3) gene that was successfully replicated in additional 1,124 cases and 12,510 controls. A subsequent joint meta-analysis of the discov…

The landscape of epilepsy-related GATOR1 variants

2019

Purpose:\ud \ud To define the phenotypic and mutational spectrum of epilepsies related to DEPDC5, NPRL2 and NPRL3 genes encoding the GATOR1 complex, a negative regulator of the mTORC1 pathway.\ud \ud Methods:\ud \ud We analyzed clinical and genetic data of 73 novel probands (familial and sporadic) with epilepsy-related variants in GATOR1-encoding genes and proposed new guidelines for clinical interpretation of GATOR1 variants.\ud \ud Results:\ud \ud The GATOR1 seizure phenotype consisted mostly in focal seizures (e.g., hypermotor or frontal lobe seizures in 50%), with a mean age at onset of 4.4 years, often sleep-related and drug-resistant (54%), and associated with focal cortical dysplasia…

Non-alcoholic fatty liver disease in adults 2021: A clinical practice guideline of the Italian Association for the Study of the Liver (AISF), the Ita…

2021

Nonalcoholic fatty liver disease (NAFLD) is a common and emerging liver disease in adults, paralleling the epidemic of obesity and diabetes, and leading to worrisome events (hepatocellular carcinoma and end-stage liver disease). In the last years, mounting evidence added insights about epidemiology, natural history, diagnosis and lifestyle-based or drug treatment of NAFLD. In this rapidly evolving scenario, members of the Associazione Italiana per lo Studio del Fegato (AISF), the Società Italiana di Diabetologia (SID) and the Società Italiana dell'Obesità (SIO) reviewed current knowledge on NAFLD. The quality of the published evidence is graded, and practical recommendations are made follow…

Immunohistochemical marker for Na+ CP type Vα (C-20) and heterozygous nonsense SCN5A mutation W822X in a sudden cardiac death induced by mild anaphyl…

2009

A sudden death likely due to mild anaphylactic reaction in a young man is described. Autoptic, histologic, immunohistochemical, and laboratory findings were strongly consistent with the diagnosis of a mild anaphylactic reaction. Genetic molecular analysis, performed on formalin-fixed, paraffin-embedded tissues, showed a mutation described as W822X in a family with electrocardiographic pattern typical of Brugada Syndrome. It results in a nonsense mutation generating a truncated form of the channel protein. The mutation is due to a point substitution of a guanine with an adenine residue (G2466A). Immunohistochemistry and laser scanning confocal microscopy on sections from heart formalin-fixed…