Search results for "Sudden"
showing 10 items of 195 documents
GAMS files for the multi-objective models to locate temporary distribution centers after sudden-onset disasters
2019
These are the GAMS file with some a sample dataset that model locating temporary distribution centers after sudden-onset disasters. Required input data should be changed in the front.
Is Sauna Bathing Protective of Sudden Cardiac Death? A Review of the Evidence
2019
Sudden cardiac death (SCD) is a global public health burden accounting for 15–20% of all deaths. Though established atherosclerotic risk factors explain a large proportion of the risk of SCD, these factors are often absent in a large proportion of SCD victims and the pathogenesis of SCD is still not fully established. It therefore appears that additional factors may be involved. Sauna bathing is a traditional Finnish activity that is mainly used for the purposes of relaxation and pleasure. Beyond its use for these purposes, sauna bathing has been linked with several health benefits. Emerging evidence suggests that sauna bathing is associated with reduced risk of adverse cardiovascular (CV) …
Immunohistochemical localization of cyclooxygenase isoforms in the organ of Corti and the spiral ganglion cells of guinea pig cochlea.
2003
Prostaglandins have been used in experimental models and clinical studies for the therapy of sudden hearing loss and tinnitus with conflicting results. However, little is known about the rate-limiting enzymes of prostaglandin synthesis in the inner ear, the generally constitutively expressed cyclooxygenase 1 (COX-1) and the distress-inducible cycloxygenase 2 (COX-2). To extend our knowledge concerning the physiological expression and localization of these two enzymes, immunohistochemical stainings of the guinea pig cochlea were performed. Light microscopical analysis revealed a homogenous distribution of COX-1 within nearly all cell types of the organ of Corti, but no COX-1 expression in th…
Intermediate Filament Diseases: Desminopathy
2008
Desminopathy is one of the most common intermediate filament human disorders associated with mutations in closely interacting proteins, desmin and alphaB-crystallin. The inheritance pattern in familial desminopathy is characterized as autosomal dominant or autosomal recessive, but many cases have no family history. At least some and likely most sporadic desminopathy cases are associated with de novo DES mutations. The age of disease onset and rate of progression may vary depending on the type of inheritance and location of the causative mutation. Typically, the illness presents with lower and later upper limb muscle weakness slowly spreading to involve truncal, neck-flexor, facial and bulba…
Pharmacological treatment of sensorineural hearing loss
2019
Sudden sensorineural hearing loss is a common and alarming symptom of about 360 million people that suffer from hearing impairment worldwide. The sudden sensorineural hearing loss usually arises unilaterally and it is habitually described as greater than 30dB hearing reduction, attributable to lesions of the cochlea, cranial nerve VIII, brainstem and temporal lobe. There are many factor that promote the onset of this lesions such us infections, circulatory diseases, inner ear neoplasia and neurological disorders. This pathology is characterized by primary symptoms such as the impairment of the comprehension of spoken language and the struggling to listen to music. Subsequently, secondary sy…
A population-based study relevant to seasonal variations in causes of death in children undergoing surgery for congenital cardiac malformations
2007
AbstractAimsOur objectives were, first, to study seasonal distribution of perioperative deaths within 30 days after surgery, and late death, in children undergoing surgery for congenitally malformed hearts, and second, to study the causes of late death.MethodsWe analysed a retrospective cohort of 1,753 children with congenital cardiac malformations born and undergoing surgery in the period from 1990 through 2002 with a special focus on the causes of late death. The data was obtained from the registry of congenital cardiac malformations at Rikshospitalet, Oslo, and the Norwegian Medical Birth Registry. The mean follow-up from birth was 8.1 years, with a range from zero to 15.2 years.ResultsD…
Bi-objective multi-layer location–allocation model for the immediate aftermath of sudden-onset disasters
2019
International audience; Locating distribution centers is critical for humanitarians in the immediate aftermath of a sudden-onset disaster. A major challenge lies in balancing the complexity and uncertainty of the problem with time and resource constraints. To address this problem, we propose a location–allocation model that divides the topography of affected areas into multiple layers; considers constrained number and capacity of facilities and fleets; and allows decision-makers to explore trade-offs between response time and logistics costs. To illustrate our theoretical work, we apply the model to a real dataset from the 2015 Nepal earthquake response. For this case, our method results in…
Impaired Binding to Junctophilin-2 and Nanostructural Alteration in CPVT Mutation
2021
Rationale: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare disease, manifested by syncope or sudden death in children or young adults under stress conditions. Mutations in the Ca 2+ release channel/RyR2 (type 2 ryanodine receptor) gene account for about 60% of the identified mutations. Recently, we found and described a mutation in RyR2 N-terminal domain, RyR2 R420Q . Objective: To determine the arrhythmogenic mechanisms of this mutation. Methods and Results: Ventricular tachycardias under stress conditions were observed in both patients with catecholaminergic polymorphic ventricular tachycardia and knock-in mice. During action potential recording (by patch-clamp in …
Job in Literature
1997
This classic counsel of despair is uttered by Job’s wife in the wake of all the evils which befall him (Job 2:9). It is preceded by the question, ‘Dost thou still retain thine integrity?’ Her words may have been motivated by bitterness over what she and Job had endured (the Septuagint and the apocryphal Testament of Job both give her a lengthy speech in which she catalogues their degradation). Possibly she felt that blasphemy would have sudden death as a consequence, and that this would put Job out of his misery. In any case, the import of her words is to question the value of ‘righteousness’ (cf. Tobit 2:11–14).
Pancreatitis aguda necrótico-hemorrágica: propósito de dos autopsias judiciales
2015
la pancreatitis necrótico-hemorrágica, es una complicación inusual y altamente mortal en los casos de inflamación de la glándula pancreática. El diagnóstico es de sospecha clínica apoyado por pruebas de laboratorio y de radiodiagnóstico. Constituye una causa excepcional de muerte súbita. Pero esta forma de presentación de pancreatitis sólo puede ser confirmada mediante el estudio anatomopatológico de la glándula, del cual se dispone en raras ocasiones. Exponemos los hallazgos macroscópicos de dos casos mortales de Pancreatitis Aguda Necro-Hemorrágica. hemorrhagic and necrotizing pancreatitis, is an unusual and highly lethal complication in cases of inflammation of the pancreatic gland. The …