Search results for "Sulfatide"
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The janus face of NKT cell function in autoimmunity and infectious diseases
2018
Natural killer T cells (NKT) are a subset of T lymphocytes bridging innate and adaptive immunity. These cells recognize self and microbial glycolipids bound to non-polymorphic and highly conserved CD1d molecules. Three NKT cell subsets, type I, II and NKT-like expressing different antigen receptors (TCR) were described and TCR activation promotes intracellular events leading to specific functional activities. NKT can exhibit different functions depending on the secretion of soluble molecules and the interaction with other cell types. NKT cells act as regulatory cells in the defence against infections but, on the other hand, their effector functions can be involved in the pathogenesis of sev…
the role of lipids in the pathogenesis of neuroHIV
2020
A critical comorbidity of HIV infection is HIV-associated neurocognitive disorders (HAND). Although combined antiretroviral therapy (cART) is an effective treatment in blocking systemic viral replication, it is unsuccessful in reducing the incidence of HAND. HIV CNS damage, in the current cART era, can be associated to the presence of latently HIV-infected cells including microglia/macrophages and a small population of astrocytes. This Ph.D. thesis focuses on identifying, localizing, and quantifying viral reservoirs using an improved staining and microscopy technique. Although in low amount, our data confirmed that microglia/macrophages and a small population of astrocytes are still infecte…