Search results for "Sulfoxide"

showing 10 items of 313 documents

H2-Antihistaminika, 3. Mitt. Synthese und H2-antihistaminische Wirksamkeit Metiamid-analoger Sulfoxide und Sulfone

1979

Als potentielle H2-Anthistaminika wurden Sulfoxide und Sulfone dargestellt und auf ihre H2-antihistaminische Wirksamkeit untersucht. H2-Antihistaminics, III: Synthesis, and H2-Antihistaminic Activity of Sulfoxides and Sulfones Analogous to Metiamide Potentially active sulfoxides and sulfones were prepared and tested for their H2-antihistaminic activity.

chemistry.chemical_compoundChemistryDrug DiscoverymedicinePharmaceutical ScienceOrganic chemistrySulfoxideMetiamidemedicine.drugSulfoneArchiv der Pharmazie
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Mechanism of the oxidation of sulfides by dioxiranes: conformational mobility and transannular interaction in the oxidation of thianthrene 5-oxide.

2004

The detailed study of the oxidation of thianthrene 5-oxide (1) with methyl(trifluoromethyl)dioxirane (5b) in different solvents and in the presence of (18)O isotopic tracers is reported. Thianthrene 5-oxide (1) is a flexible molecule in solution, and this property allows for transannular interaction of the sulfoxide group with the expected zwitterionic 7 and hypervalent 10-S-4 sulfurane 9 intermediates formed in the oxidation and biases the course of the reaction toward the monooxygenation pathway.

chemistry.chemical_compoundReaction mechanismTrifluoromethylchemistryDioxiraneZwitterionOrganic ChemistryHypervalent moleculeSulfoxideSolvent effectsPhotochemistryThianthreneThe Journal of organic chemistry
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First synthesis of chiral 3-vinylindoles as 4π-components for diels-alder reactions

1995

The first syntheses of chiral 3- and 2-vinylindoles bearing sulfoxide or (-)-menthyloxy functional groups at the β-vinyl positions by way of procedures based on the Horner-Wadsworth-Emmons and Wittig reactions, respectively, are described. Some Diels-Alder reactions demonstrating the 4π-reactivity of these compounds are reported.

chemistry.chemical_compoundchemistryOrganic ChemistryWittig reactionDiels alderOrganic chemistrySulfoxideJournal of Heterocyclic Chemistry
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ChemInform Abstract: First Synthesis of Chiral 3-Vinylindoles as 4π-Components for Diels- Alder Reactions.

2010

The first syntheses of chiral 3- and 2-vinylindoles bearing sulfoxide or (-)-menthyloxy functional groups at the β-vinyl positions by way of procedures based on the Horner-Wadsworth-Emmons and Wittig reactions, respectively, are described. Some Diels-Alder reactions demonstrating the 4π-reactivity of these compounds are reported.

chemistry.chemical_compoundchemistryWittig reactionDiels alderOrganic chemistrySulfoxideGeneral MedicineChemInform
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Crystal structure of di-μ-isobutyrato-κ(4) O:O'-bis-[cis-di-chlorido-(dimethyl sulfoxide-κS)rhenium(III)].

2015

A binuclear bis­(carboxyl­ato)dirhenium(III) complex is reported. The compound is a representative of a small class of alkyl­carboxyl­ate complexes involving a quadruple metal–metal bonds

crystal structurechemistry.chemical_elementNanotechnologyCrystal structureChlorideIonResearch CommunicationsCrystalchemistry.chemical_compoundquadruple metal–metal bondalkylcarboxylate complexmedicineCluster (physics)General Materials ScienceclusterCrystallographyDimethyl sulfoxideHydrogen bondGeneral ChemistryRheniumCondensed Matter Physicshydrogen bondingrhenium(III)CrystallographychemistryQD901-999alkyl­carboxyl­ate complexmedicine.drugActa crystallographica. Section E, Crystallographic communications
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CCDC 1477312: Experimental Crystal Structure Determination

2016

Related Article: Rajendhraprasad Tatikonda, Sandip Bhowmik, Kari Rissanen, Matti Haukka, Massimo Cametti|2016|Dalton Trans.|45|12756|doi:10.1039/C6DT02008A

dichloro-(4'-((4455667788991010111111-heptadecafluoroundecyl)oxy)-22':6'2''-terpyridine)-copper(ii) dimethyl sulfoxide solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1477309: Experimental Crystal Structure Determination

2016

Related Article: Rajendhraprasad Tatikonda, Sandip Bhowmik, Kari Rissanen, Matti Haukka, Massimo Cametti|2016|Dalton Trans.|45|12756|doi:10.1039/C6DT02008A

dichloro-(4'-((4455667788991010111111-heptadecafluoroundecyl)oxy)-22':6'2''-terpyridine)-zinc(ii) dimethyl sulfoxide solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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First Synthesis of β-Keto Sulfoxides by a Palladium-Catalyzed Carbonylative Suzuki Reaction

2005

[reaction: see text] An unprecedented palladium-catalyzed three-component cross-coupling reaction between alpha-bromo sulfoxide, carbon monoxide, and aromatic boronic acids provides a new and efficient approach to the synthesis of beta-ketosulfoxides. The reaction takes place under mild conditions with a wide range of variously substituted aryl and heteroaryl boronic acids. The carbonylative cross-coupling reaction is strongly favored over competing direct cross-coupling and homocoupling processes, except with boronic acids carrying strong electron-withdrawing substituents.

inorganic chemicalsArylOrganic Chemistrychemistry.chemical_elementSulfoxideGeneral MedicineBiochemistryMedicinal chemistryCatalysischemistry.chemical_compoundchemistrySuzuki reactionOrganic chemistryPhysical and Theoretical ChemistryCarbonylationCarbon monoxidePalladiumOrganic Letters
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Vitrification of zona-free rabbit expanded or hatching blastocysts: a possible model for human blastocysts.

2003

BACKGROUND: The purpose of this study was to test the effectiveness of one two-step (A) and two one-step (B1 and B2) vitrification procedures on denuded expanded or hatching rabbit blastocysts held in standard sealed plastic straws as a possible model for human blastocysts. The effect of blastocyst size was also studied on the basis of three size categories (I: diameter <200 μm; II: diameter 200-299 μm; III: diameter ≥300 μm). METHODS: Rabbit expanded or hatching blastocysts were vitrified at day 4 or 5. Before vitrification, the zona pellucida was removed using acidic phosphate buffered saline. For the two-step procedure, prior to vitrification, blastocysts were pre-equilibrated in a solut…

medicine.medical_specialtyHot TemperatureZona freeBiologyAndrologychemistry.chemical_compoundEmbryonic and Fetal DevelopmentmedicineAnimalsHumansVitrificationBlastocystZona pellucidaZona PellucidaCryopreservationTissue SurvivalDimethyl sulfoxideHatchingRehabilitationHistological TechniquesObstetrics and GynecologyEmbryoSurgerymedicine.anatomical_structureBlastocystReproductive MedicinechemistryModels AnimalFemaleRabbitsEthylene glycolHuman reproduction (Oxford, England)
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Viability and function of the cryopreserved whole rat ovary: comparison between slow-freezing and vitrification

2011

Objective To investigate four different protocols for cryopreservation of the whole rat ovary with intact vasculature to evaluate whether differences exist in post-thawing viability of the ovary after either vitrification or slow freezing. Design Experimental study. Setting Obstetrics and gynecology department. Animal(s) Immature Sprague-Dawley female rats. Intervention(s) Ovaries were isolated with the vascular tree intact up to the bifurcation of the abdominal aorta and were subsequently cannulated. The ovaries were flushed with increasing concentrations of the cryoprotectant dimethyl sulfoxide (DMSO) to either 1.5 or 7 M. The ovaries underwent cryopreservation by vitrification or passive…

medicine.medical_specialtyNeutral redTime FactorsCryoprotectantApoptosisOvaryBiologyCryopreservationRats Sprague-DawleyTissue Culture TechniquesAndrologychemistry.chemical_compoundCryoprotective AgentsOvarian FollicleFreezingFollicular phasemedicineAnimalsDimethyl SulfoxideVitrificationIncubationCryopreservationTissue SurvivalGynecologyDose-Response Relationship DrugEstradiolCaspase 3Dimethyl sulfoxideOvaryFertility PreservationObstetrics and GynecologyOrgan PreservationImmunohistochemistryVitrificationRatsPerfusionmedicine.anatomical_structureReproductive MedicinechemistryFemaleFertility and Sterility
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