Search results for "Supranuclear Palsy"

showing 3 items of 13 documents

Depressive Symptom Profiles Predict Specific Neurodegenerative Disease Syndromes in Early Stages

2020

Background: During early stages, patients with neurodegenerative diseases (NDG) often present with depressive symptoms. However, because depression is a heterogeneous disorder, more precise delineation of the specific depressive symptom profiles that arise early in distinct NDG syndromes is necessary to enhance patient diagnosis and care. Methods and Findings: Five-hundred and sixty four participants self-reported their depressive symptoms using the Geriatric Depression Scale (GDS), including 111 healthy older control subjects (NC) and 453 patients diagnosed with one of six NDGs who were at the mild stage of disease (CDR® Dementia Staging Instrument ≤ 1) [186 Alzheimer's disease (AD), 76 be…

PediatricsAgingDiseaseNeurodegenerativeAlzheimer's Diseasefrontotemporal dementialcsh:RC346-429Primary progressive aphasia0302 clinical medicineneurodegenerative diseasehopelessnessworry2.1 Biological and endogenous factorsPsychology030212 general & internal medicineAetiologyDepression (differential diagnoses)Original ResearchdysphoraDepressionAlzheimer'sFrontotemporal Dementia (FTD)Mental HealthNeurologyNeurologicaldepressionGeriatric Depression Scalemedicine.symptomFrontotemporal dementiamedicine.medical_specialtyClinical SciencesDysphoriaProgressive supranuclear palsy7.3 Management and decision making03 medical and health sciencesRare DiseasesClinical ResearchBehavioral and Social SciencemedicineAcquired Cognitive ImpairmentDementialcsh:Neurology. Diseases of the nervous systembusiness.industryNeurosciencesAlzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD)progressive supranuclear palsymedicine.diseaseBrain DisordersGood Health and Well BeingDementiaNeurology (clinical)Management of diseases and conditionsbusiness030217 neurology & neurosurgeryFrontiers in Neurology
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Clinical manifestations of the anti-IgLON5 disease

2017

Objective:To report the presentation, main syndromes, human leukocyte antigen (HLA) association, and immunoglobulin G (IgG) subclass in the anti-IgLON5 disease: a disorder with parasomnias, sleep apnea, and IgLON5 antibodies.Methods:This was a retrospective clinical analysis of 22 patients. The IgG subclass was determined using reported techniques.Results:Patients' median age was 64 years (range 46–83). Symptoms that led to initial consultation included sleep problems (8 patients; 36%), gait abnormalities (8; 36%), bulbar dysfunction (3; 14%), chorea (2; 9%), and cognitive decline (1; 5%). By the time of diagnosis of the disorder, 4 syndromes were identified: (1) a sleep disorder with paras…

Sleep Wake Disorders0301 basic medicinemedicine.medical_specialtyCell Adhesion Molecules NeuronalPopulationExcessive daytime sleepinessAutoimmune DiseasesProgressive supranuclear palsy03 medical and health sciences0302 clinical medicineInternal medicinemedicineHumansCognitive declineeducationAgedAutoantibodiesRetrospective StudiesAged 80 and overeducation.field_of_studySleep disorderbusiness.industryBrainSleep apneaChoreaParasomniaMiddle Agedmedicine.disease030104 developmental biologyImmunoglobulin GImmunotherapyNeurology (clinical)medicine.symptomCarrier ProteinsbusinessBiomarkers030217 neurology & neurosurgeryHLA-DRB1 ChainsNeurology
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Ocular motor biomarkers in Niemann-Pick disease type C: A prospective cross-sectional multicontinental study in 72 patients

2020

AbstractNiemann-Pick type C (NPC) is a rare lysosomal storage disorder with ocular motor involvement. In a multicontinental, cross-sectional study we characterized ocular motor function in 72 genetically proven patients from twelve countries by means of video-oculography. Interlinking with disease severity, we also searched for ocular motor biomarkers. Our study protocol comprised reflexive and self-paced saccades, smooth pursuit, and gaze-holding in horizontal and vertical planes. Data were compared with those of 158 healthy controls. The Modified Disability Rating Scale, Scale for Assessment and Rating of Ataxia, Spinocerebellar Ataxia Functional Index for neurological status, and Montrea…

medicine.medical_specialtyAtaxiaVertical supranuclear gaze palsyPalsygenetic structuresbusiness.industrymedicine.diseaseSaccadic maskingSmooth pursuitProgressive supranuclear palsyPhysical medicine and rehabilitationSaccademedicineSpinocerebellar ataxiamedicine.symptombusiness
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