Search results for "Survivin"
showing 7 items of 57 documents
Primo Levi, a critic humanist
2015
La intención de este escrito es reflexionar sobre el pensamiento del italiano Primo Levi y defender como apropiado el referirnos a él como un ‘humanista crítico’. Para ello seguimos los criterios propuestos por T. Todorov para caracterizar la doctrina humanista en tres elementos: autonomía del yo, finalidad del tú y universalidad de los ellos, y los propios del humanismo crítico, único posible tras lo ocurrido en Auschwitz y Kolyma: el reconocimiento del horror del que somos capaces los seres humanos y la afirmación de la posibilidad del bien. Palabras-clave: Humanismo crítico, Campos de concentración, Sobreviviente,Testimonio, Memoria. The aim of this research is to reflect upon the though…
Primo Levi, a critic humanist
2015
La intención de este escrito es reflexionar sobre el pensamiento del italiano Primo Levi y defender como apropiado el referirnos a él como un ‘humanista crítico’. Para ello seguimos los criterios propuestos por T. Todorov para caracterizar la doctrina humanista en tres elementos: autonomía del yo, finalidad del tú y universalidad de los ellos, y los propios del humanismo crítico, único posible tras lo ocurrido en Auschwitz y Kolyma: el reconocimiento del horror del que somos capaces los seres humanos y la afirmación de la posibilidad del bien. Palabras-clave: Humanismo crítico, Campos de concentración, Sobreviviente,Testimonio, Memoria. The aim of this research is to reflect upon the though…
New insights into the diversity dynamics of Triassic conodonts
2013
International audience; In this paper, we examine the diversity trends and the evolutionary patterns of Triassic conodonts through a newly powered large-scale data-set compiled directly from the primary literature. Paleodiversity dynamics analyses have been undertaken by working at the species level and using a system of time units based on biozone subdivisions for a fine temporal level resolution. The role of heterogeneous duration of taxa in diversity estimates has been evaluated through the probabilistic profiles. Results reveal three different stages in the diversity behaviour of Triassic conodonts from standing metrics delimited by two inflections at the mid-Anisian and mid-Carnian. Su…
Colorectal Cancer Stem Cells and Cell Death
2011
Nowadays it is reported that, similarly to other solid tumors, colorectal cancer is sustained by a rare subset of cancer stem-like cells (CSCs), which survive conventional anticancer treatments, hanks to efficient mechanisms allowing escape from apoptosis, triggering tumor recurrence. To improve patient outcomes, conventional anticancer therapies have to be replaced with specific approaches targeting CSCs. In this review we provide strong support that BMP4 is an innovative therapeutic approach to prevent colon cancer growth increasing differentiation markers expression and apoptosis. Recent data suggest that in colorectal CSCs, protection from apoptosis is achieved by interleukin-4 (IL-4) a…
SF002-96-1, a new drimane sesquiterpene lactone from an Aspergillus species, inhibits survivin expression
2013
Survivin, a member of the IAP (inhibitor of apoptosis) gene family, is overexpressed in virtually all human cancers and is functionally involved in the inhibition of apoptosis, regulation of cell proliferation, metastasis and resistance to therapy. Because of its upregulation in malignancy, survivin has currently attracting considerable interest as a new target for anticancer therapy. In a screening of approximately 200 strains of imperfect fungi for the production of inhibitors of survivin promoter activity, a new drimane sesquiterpene lactone, SF002-96-1, was isolated from fermentations of an Aspergillus species. The compound inhibited survivin promoter activity in transiently transfected…
Induction of apoptosis by the proteasome inhibitor MG132 in human HCC cells: Possible correlation with specific caspase-dependent cleavage of β-caten…
2004
Proteasome inhibitors, like MG132, can exert cell growth inhibitory and apoptotic effects in different tumor types. The apoptotic mechanism of these compounds involves the activation of the effector caspases. beta-catenin, also an oncogene, represents one of the substrates of these proteases, but the consequences of its cleavage are poorly understood. We investigated its function during apoptosis induced by MG132 in three hepatocellular carcinoma (HCC) cell lines, endowed (HepG2 and HuH-6) or not (HA22T/VGH) with activating mutations of beta-catenin. Induction of apoptosis was associated with cell growth inhibition, accumulation of the cells at the G(2)/M phases of the cell cycle, as well a…
Histamine and spontaneously released mast cell granules affect the cell growth of human hepatocellular carcinoma cells
2007
The role of mast cells in tumor growth is still controversial. In this study we analyzed the effects of both histamine and pre-formed mediators spontaneously released by mast cells on the growth of two human hepatocellular carcinoma cell lines, HA22T/VGH and HuH-6, with different characteristics of differentiation, biological behavior and genetic defects. We showed that total mast cell releasate, exocytosed granules (granule remnants) and histamine reduced cell viability and proliferation in HuH-6 cells. In contrast, in HA22T/VGH cells granule remnants and histamine induced a weak but significant increase in cell growth. We showed that both cell lines expressed histamine receptors H(1) and …