Search results for "Sympatholytic"
showing 6 items of 36 documents
Der Antagonismus verschiedener Sympatholytica gegen�ber dem inhibitorischen Adrenalin- oder Noradrenalineffekt am elektrisch gereizten Meerschweinche…
1958
Adrenaline and noradrenaline were found to depress the contractions of the electrically stimulated isolated ileum of the guinea-pig; this action was related to the dose. In these experiments smaller amounts of adrenaline were required than those necessary for the depression of the spontaneous movements of the isolated rabbit duodenum.
Functional consequences of prejunctional receptor activation or blockade in the iris.
1994
The iris is innervated by nerves of the sympathetic, parasympathetic, and sensory nervous systems. The terminal nerve fibres are endowed with prejunctional receptors which modulate neurotransmitter release. Activation or blockade of prejunctional receptors by drugs may have an influence on iris smooth muscle tone. Several findings are in favour of the hypothesis that prejunctional receptors may be involved in regulation of iris smooth muscle tone and/or pathophysiological events. (i). Release of acetylcholine from parasympathetic nerves of guinea-pig iris sphincter evoked by electrical stimulation is subject to autoinhibition via prejunctional M2 muscarinic receptors, and the release can be…
Absorption of oxybutynin from vaginal inserts: drug blood levels and the response of the rabbit bladder.
2000
Abstract Objectives. Oxybutynin has been used for treatment of urge urinary incontinence for more than 20 years. However, one of the major problems with its use is uncomfortable anticholinergic side effects that can lead to discontinuation of treatment. Alternative forms of drug administration may reduce side effects and thus improve patient compliance. Methods. A cylinder-shaped, curved silicone elastomer insert containing oxybutynin was anchored in the vagina of female rabbits. The inserts were designed to release oxybutynin at rates of 0.5, 1.0, and 5.0 mg/day, respectively. Blood drug and metabolite levels were monitored for 1 to 7 days and cystometry was carried out after 7 days of tre…
Antihistaminic and anticholinergic activities of mequitazine in comparison with clemizole
1988
Abstract The antihistamine and anticholinergic properties of mequitazine have been investigated and compared with those of clemizole. Both mequitazine and clemizole antagonized the effect of histamine in guinea-pig ileum competitively, the pA2 values calculated by Schild plot were 9.95 ± 0.44 for mequitazine and 10.54 ± 0.44 for clemizole. Mequitazine at 10−7 M produced a parallel shift of the dose-response curve to acetylcholine in the rat duodenum, clemizole and the lower doses of mequitazine failed to modify the effect of acetylcholine. The potency of mequitazine and clemizole as H1-histamine blockers is similar, but only mequitazine at highest concentration used showed anticholinergic a…
Characterization of prejunctional muscarinic autoreceptors in the guinea-pig trachea
1991
1. The effects of ten muscarinic antagonists on electrically evoked [3H]-acetylcholine release and muscle contraction were compared in an epithelium-free preparation of the guinea-pig trachea that had been preincubated with [3H]-choline. 2. The M3-selective antagonists UH-AH 37, 4-diphenyl-acetoxy-N-piperidine methobromide and para-fluorohexahydrosiladiphenidol were more potent in reducing the contractile response than in facilitating the evoked [3H]-acetylcholine release. Hexahydrosiladiphenidol did not discriminate between pre- and postjunctional effects. The rank order of the postjunctional potencies of the ten antagonists as well as the postjunctional pA2 values obtained for hexahydrosi…
Motor activity in group-housed and isolated mice with short and long attack latencies: Effects of scopolamine
2002
Isolation-induced behavioral changes are well described in mice, although few studies have investigated the involvement of the cholinergic system in these effects. It has also been suggested that mice that display short or long attack latencies show differences in their reactions to a novel environment. The purpose of the present study was, first, to investigate locomotor activity in grouped and isolated mice that displayed short or long attack latencies and, second, to evaluate locomotor activity to determine whether it was affected interactively by differential housing and scopolamine treatment. Two experiments were performed in which NMRI mice, either isolated or group housed, were used …