Search results for "Synthetic"

On the hygrothermal behavior of coconuts fiber insulators on green roofs.

2020

Coconut fibre insulators, represent an insulating material considered as “exotic”, which clashes with the doubts of his thermo-hygrometric behavior, in particular, in the case of covering technology such as green roofs, a technological solution adopted in the case of sustainable buildings or nearly zero energy building. Green roofs represent a valid constructive solution with high thermal performances, adopted in existing and new buildings. The purpose of the research regards the study of the thermo-hygrometric behavior of the concrete and Cross-Laminated Timber (CLT) slabs, insulated with coconut fibre-boards (CF) such as alternative synthetic insulators, referred to 10 different green roo…

The miniaturised emission chamber system and home-made passive flux sampler studies of monoaromatic hydrocarbons emissions from selected commercially…

2017

Abstract The estimation of the emission rate of organic compounds released from various types of indoor materials can be performed using stationary environmental test chambers (ETC) classified as ex-situ methods or small-scale portable analytical devices based on the use of passive technique at the stage of analytes sampling from the gaseous phase (in-situ methods). The paper presents results of emissions of selected organic compounds from the monoaromatic hydrocarbons group (benzene, toluene, ethylbenzene, p,m-xylene and styrene) emitted from the surfaces of various types of commercially-available floor coverings and the underlay made of polyurethane foam which might be installed indoors u…

Standards not that standard

2015

There is a general assent on the key role of standards in Synthetic Biology. In two consecutive letters to this journal, suggestions on the assembly methods for the Registry of standard biological parts have been described. We fully agree with those authors on the need of a more flexible building strategy and we highlight in the present work two major functional challenges standardization efforts have to deal with: the need of both universal and orthogonal behaviors. We provide experimental data that clearly indicate that such engineering requirements should not be taken for granted in Synthetic Biology. Electronic supplementary material The online version of this article (doi:10.1186/s1303…

Biochemical indicators for novel forest decline in spruce

1998

Abstract The impact of air pollution on 24 stands of spruce trees in several regions in Germany was investigated. We looked for evidence of biochemical and physiological change at the level of the photosynthetic thylakoid membranes as well as for changes in the antioxidative system in two year old needles. We observed that, as the chlorophyll content decreases in the needles, the amoung of D1 protein declines far more rapidly in relation to the redox components P700 and cytochrome f. Consequently, the PSII/PSI stoichiometry keeps dropping to pregressively lower, meaning unfavorable, values at the chlorophyll content diminishes. This is particularly the case in the higher elevation character…

Network pharmacology of cancer: From understanding of complex interactomes to the design of multi-target specific therapeutics from nature

2015

Despite massive investments in drug research and development, the significant decline in the number of new drugs approved or translated to clinical use raises the question, whether single targeted drug discovery is the right approach. To combat complex systemic diseases that harbour robust biological networks such as cancer, single target intervention is proved to be ineffective. In such cases, network pharmacology approaches are highly useful, because they differ from conventional drug discovery by addressing the ability of drugs to target numerous proteins or networks involved in a disease. Pleiotropic natural products are one of the promising strategies due to their multi-targeting and d…

Fully synthetic self-adjuvanting thioether-conjugated glycopeptide-lipopeptide antitumor vaccines for the induction of complement-dependent cytotoxic…

2012

Glycopeptides of tumor-associated mucin MUC1 are promising target structures for the development of antitumor vaccines. Because these endogenous structures were weakly immunogenic, they were coupled to immune-response-stimulating T-cell epitopes and the Pam(3)Cys lipopeptide to induce strong immune responses in mice. A new thioether-ligation method for the synthesis of two- and three-component vaccines that contain MUC1 glycopeptides as the B-cell epitopes, a T-cell epitope peptide, and the Pam(3)CSK(4) lipopeptide is described. The resulting fully synthetic vaccines were used for the vaccination of mice, either in a liposome with Freund's adjuvant or in aqueous PBS buffer. The three-compon…

Reactions at Interfaces: Oxygenation of n-Butyl Ligands Anchored on Silica Surfaces with Methyl(trifluoromethyl)dioxirane

2011

The oxygenation of n-butyl and n-butoxy chains bonded to silica with methyl(trifluoromethyl)dioxirane (1) revealed the ability of the silica matrix to release electron density toward the reacting C(2)-H σ-bond through the Si-C(1) and Si-O(1) σ-bonds connecting the alkyl chain to the surface (silicon β-effect). The silica surface impedes neither the alkyl chain adopting the conformation required for the silicon β-effect nor dioxirane 1 approaching the reactive C(2) methylene group. Reaction regioselectivity is insensitive to changes in the solvation of the reacting system, the location of organic ligands on the silica surface, and the H-bonding character of the silica surface. Reaction rates…

Paving the way for synthetic biology‐based bioremediation in Europe

2010

Opioid epidemic spread from Northern and Eastern Europe to Mediterranean Area.

2021

The addiction to illicit opioid and the misuse of prescription synthetic opioids pain relievers and fentanyl analogs generated an opioid epidemic in North America over the last two decades that affected public health with a constantly rising number of overdoses deaths. This health treat moved to Europe with a significant increase starting from 2015 involving mainly norther and eastern countries and finally also the Mediterranean area. The "lock down" isolation and economic recession caused by COVID-19 pandemic showed a resurgence in opioid use and harms.

Direct validation of FVC, LAI and FAPAR VEGETATION/SPOT derived products using LSA SAF methodology

2007

The aim of this work is to perform a direct validation of fraction of vegetation cover (FVC), leaf area index (LAI) and fraction of absorbed photosynthetically active radiation (FAPAR) resulting products from applying the LSA SAF methodology to VEGETATION BRDF data. LSA SAF adapted algorithms were tested in adequate test sites comprising different continental biomes covering a wide range of FVC, LAI and FAPAR values. Results seem to indicate the competitiveness of LSA SAF proposed methodology to retrieve remotely sensed biophysical parameters. A noticeable good agreement regarding the ground measurements was found. The overall accuracy (RAISE) is around 20% for FVC and FAPAR and around 15% …