Search results for "System a"
showing 10 items of 111 documents
Use without training: A case study of evidence-based software design for intuitive use
2019
This paper reviews intuitive software design and outlines the development of an instrument for analysts to evaluate the intuitiveness of software design. Current intuition research outlines three requirements for intuitive use: (a) existing experiential domain knowledge and skills, (b) an unexplainable perception that a novel situation is contextually familiar, and (c) successful application of users’ previously acquired experiential knowledge and skills. A case study illustrates how these requirements can be specified, implemented, and evaluated. Questions to evaluate the characteristics of intuitive design and use resulted in an intuitive use evaluation of 3.2 on a scale of 0–4, indicatin…
GABA transporters control GABAergic neurotransmission in the mouse subplate.
2015
The subplate is a transient layer between the cortical plate and intermediate zone in the developing cortex. Thalamo-cortical axons form temporary synapses on subplate neurons (SPns) before invading the cortical plate. Neuronal activity within the subplate is of critical importance for the development of neocortical circuits and architecture. Although both glutamatergic and GABAergic inputs on SPns were reported, short-term plasticity of GABAergic transmission has not been investigated yet. GABAergic postsynaptic currents (GPSCs) were recorded from SPns in coronal neocortical slices prepared from postnatal day 3-4 mice using whole-cell patch-clamp technique. Evoked GPSCs (eGPSCs) elicited b…
Journalist–source relations and the deliberative system: A network performance approach to investigating journalism’s contribution to facilitating pu…
2018
Journalist–source relationships and interactions are interpreted in this study as crucial mechanisms for linking different arenas in a deliberative system. To unravel these source networks, 106 semi-standardized interviews with journalists as well as public relations (PR) professionals from government delegations and non-governmental organizations were conducted on-site three United Nations (UN) climate change conferences between 2010 and 2013, and an online survey was administered during the conference in 2015. The analysis shows that most journalists maintain close relationships with their home country delegation. However, journalists experienced in climate conference coverage also maint…
Cavity Ring-Down Spectroscopy measurements of Acetone concentration
2017
This research has been partly supported by the National Research Programme "The next generation of information and communication technologies" (NexIT).
THE BASE SYSTEM: A SCHOOL-WIDE POSITIVE BEHAVIOUR SUPPORT TOOL TO FACILITATE EVIDENCE-BASED DIGITAL INTERVENTION PRACTICES
2019
The Positive Behaviour Intervention and Support system is a framework aimed to introduce a change at school-wide level. It promotes a disciplinary system change process, from a reactive punishment- based strategies of specific student misbehaviours to a proactive system, where different behavioural principles such as the modelling and reinforcement of positive prosocial students’ behaviours are applied to improve school values and to create a positive climate. This paper presents the Behavioural Assessment to improve School Environment (BASE) system and the BASE repository. The BASE system supports evidence-based digital intervention practices for stimulating the academic, social, emotional…
A nested virtualization tool for information technology practical education
2016
Background A common problem of some information technology courses is the difficulty of providing practical exercises. Although different approaches have been followed to solve this problem, it is still an open issue, specially in security and computer network courses. Results This paper proposes NETinVM, a tool based on nested virtualization that includes a fully functional lab, comprising several computers and networks, in a single virtual machine. It also analyzes and evaluates how it has been used in different teaching environments. Conclusions The results show that this tool makes it possible to perform demos, labs and practical exercises, greatly appreciated by the students, that woul…
DCTN1 mutation analysis in Italian patients with PSP, MSA, and DLB
2020
Abstract DCTN1 encodes the largest subunit of dynactin complex essential in the retrograde axonal transport and cytoplasmic transport of vesicles; mutations in DCTN1 have been reported predominantly in individuals with Perry syndrome and, recently, in patients with progressive supranuclear palsy. Our genetic screening of DCTN1 in 79 patients with progressive supranuclear palsy, 100 patients with multiple system atrophy, and 28 patients with dementia with Lewy bodies from Italy revealed only synonymous and intronic variants, suggesting that DCTN1 mutations do not have a key role in the development of atypical parkinsonism in the Italian population.
CiC3-1a-Mediated Chemotaxis in the Deuterostome Invertebrate Ciona intestinalis (Urochordata)
2003
Abstract Deuterostome invertebrates possess complement genes, and in limited instances complement-mediated functions have been reported in these organisms. However, the organization of the complement pathway(s), as well as the functions exerted by the cloned gene products, are largely unknown. To address the issue of the presence of an inflammatory pathway in ascidians, we expressed in Escherichia coli the fragment of Ciona intestinalis C3-1 corresponding to mammalian complement C3a (rCiC3-1a) and assessed its chemotactic activity on C. intestinalis hemocytes. We found that the migration of C. intestinalis hemocytes toward rCiC3-1a was dose dependent, peaking at 500 nM, and was specific for…
Paving the way for the Paris Agreement:Contributions of SDEWES science
2023
Today, coal is responsible for 40% of annual CO2 emissions. At the same time, global warming causes climate changes accompanied with catastrophic meteorological phenomena all over the world. After the 2015 Paris Agriment many countries set ambitious energy policy to reduce the annual greenhouse gas emission. The 2021 UN Climate Change Conference, COP26 - Glasgow, ended with the adoption of a less stringent resolution than some anticipated: countries only agreed to “phase down” rather than “phase out” coal. Is possible the realization of the Paris Agreement after COP-26? For achieving this ambitious targets in such conditions, the support of the multi-disciplinary scientific knowledge is nee…
The synthesis of SNAT2 transporters is required for the hypertonic stimulation of system A transport activity
2004
AbstractIn cultured human fibroblasts incubated under hypertonic conditions, the stimulation of system A for neutral amino acid transport, associated to the increased expression of the mRNA for SNAT2 transporter, leads to an expanded intracellular amino acid pool and to the recovery of cell volume. A protein of nearly 60 kDa, recognized by an antiserum against SNAT2, is increased both in the pool of biotinylated membrane proteins and in the total cell lysate of hypertonically stressed cells. The increased level of SNAT2 transporters in hypertonically stressed cells is confirmed by immunocytochemistry. DRB, an inhibitor of transcription, substantially inhibits the increase of SNAT2 proteins …