Search results for "Systemic."

Salvage treatment with ganciclovir in a splenectomized, polytransfused patient affected by systemic inflammatory response syndrome

2014

A 23-year-old man was admitted to hospital with a 12-day history of daily fever. A clinical history revealed that 10 months previously, the patient had been splenectomized and polytransfused for a severe blunt trauma. On admission, laboratory data revealed significant leukocytosis (33,230/ul). The patient's general clinical conditions rapidly worsened into a severe systemic inflammatory response syndrome in four days. After 10 days of broad-spectrum antibiotic treatment, the temperature curve was unmodified and severe leukocytosis persisted (44,300 ul) with absolute lymphocytosis. Laboratory tests ruled out hematological diseases, pneumonia, abscesses and endocarditis. In the light of IgM …

New developments in IL-6 dependent biology and therapy: where do we stand and what are the options?

2005

Interleukin-6 (IL-6) is a four-helical protein which, on target cells, binds to a specific IL-6-receptor and two molecules of the promiscuous signal transducing protein gp130. Structure-function analysis defined three molecular contact sites between IL-6 and its receptor subunits. Using this information, competitive antagonistic proteins as well as hyperagonistic proteins were developed. Possible therapeutic applications of IL-6 antagonists are in IL-6 dependent haematological disorders (Castleman's disease, POEMS syndrome, multiple myeloma) and bone diseases (Paget's disease, osteoporosis). Designer IL-6 antagonists could suppress inflammatory activity in rheumatic and autoimmune diseases …

A cerebral nitrergic pathway modulates endotoxin-induced changes in gastric motility

2001

1 This study analyses the neural pathway involved in the modulation of gastric motor function by stress. 2 Systemic administration of low doses of endotoxin (40 m gk g 71 , i.v.) prevents the increase in gastric tone induced by 2-deoxy-D-glucose (200 mg kg 71 , i.v., 2-DG) in urethane-anaesthetized rats. 3 Functional inhibition of aAerent neurones by systemic administration of capsaicin (20+30+50 mg kg 71 , i.m.) in adult rats prevented the inhibitory eAects of endotoxin. 4 Pre-treatment with the nitric oxide synthase (NOS) inhibitor, N G -nitro-L-arginine methyl ester (LNAME), both i.v. (10 mg kg 71 ) and i.c. (200 mg rat 71 ), prevented the inhibitory eAects of endotoxin on gastric tone i…

Visión de los maestros en formación sobre los modelos científicos y sus funciones en las ciencias y en su enseñanza

2017

Este estudio examina la visión de 201 futuros maestros sobre los modelos científicos y sus funciones en ciencias y en su enseñanza. Se diseñó e implementó un cuestionario con cinco preguntas abiertas, de las cuales se analizan dos ¿Qué se entiende por modelo científico? y ¿Para qué consideras que son utilizados los modelos en ciencias? ¿Y en la enseñanza de las ciencias? Los resultados mostraron que, aunque un 24,5% reconocen que un modelo científico es una representación simplificada de un fenómeno, encontramos que un 22,8% lo consideran como “método” de trabajo de los científicos En cuanto a sus funciones, un 45,7% identifican los modelos como recursos para explicar, resumir o ejemplifica…

GiNaC - Symbolic computation with C++

2005

We give an introduction to the C++ library GiNaC, which extends the C++ language by new objects and methods for the representation and manipulation of arbitrary symbolic expressions.

The electronic structure of N-methyl-3pyridone and its representation

1970

Quasi-localized MO's have been constructed for the π electron system of the three pyridone isomers.

Multimode equivalent network representation for planar junctions involving elliptical waveguides

1996

A new representation of the Adler function for lattice QCD

2013

We address several aspects of lattice QCD calculations of the hadronic vacuum polarization and the associated Adler function. We implement a representation derived previously which allows one to access these phenomenologically important functions for a continuous set of virtualities, irrespective of the flavor structure of the current. Secondly we present a theoretical analysis of the finite-size effects on our particular representation of the Adler function, based on the operator product expansion at large momenta and on the spectral representation of the Euclidean correlator at small momenta. Finally, an analysis of the flavor structure of the electromagnetic current correlator is perform…

N-qubit states as points on the Bloch sphere

2009

We show how the Majorana representation can be used to express the pure states of an N-qubit system as points on the Bloch sphere. We compare this geometrical representation of N-qubit states with an alternative one, proposed recently by the present authors.

Squaric Ester-Based, pH-Degradable Nanogels: Modular Nanocarriers for Safe, Systemic Administration of Toll-like Receptor 7/8 Agonistic Immune Modula…

2021

Small-molecular Toll-like receptor 7/8 (TLR7/8) agonists hold promise as immune modulators for a variety of immune therapeutic purposes including cancer therapy or vaccination. However, due to their rapid systemic distribution causing difficult-to-control inflammatory off-target effects, their application is still problematic, in particular systemically. To address this problem, we designed and robustly fabricated pH-responsive nanogels serving as versatile immunodrug nanocarriers for safe delivery of TLR7/8-stimulating imidazoquinolines after intravenous administration. To this aim, a primary amine-reactive methacrylamide monomer bearing a pendant squaric ester amide is introduced, which i…