Search results for "Systemic."

Modeling recurrent distributions in streams using possible worlds

2015

Discovering changes in the data distribution of streams and discovering recurrent data distributions are challenging problems in data mining and machine learning. Both have received a lot of attention in the context of classification. With the ever increasing growth of data, however, there is a high demand of compact and universal representations of data streams that enable the user to analyze current as well as historic data without having access to the raw data. To make a first step towards this direction, we propose a condensed representation that captures the various — possibly recurrent — data distributions of the stream by extending the notion of possible worlds. The representation en…

Systemic inflammation in primary hypercholesterolemia results in platelet and leukocyte activation and their enhanced endothelial adhesiveness

2018

Contribution of molecular analyses in diagnosing Marfan syndrome and type I fibrillinopathies: an international study of 1009 probands.

2008

International audience; BACKGROUND: The diagnosis of Marfan syndrome (MFS) is usually initially based on clinical criteria according to the number of major and minor systems affected following international nosology. The number of FBN1 mutation carriers, at risk of aortic complications who would not be properly diagnosed based only on clinical grounds, is of growing importance owing to the increased availability of molecular screening. The aim of the study was to identify patients who should be considered for FBN1 mutation screening. METHODS: Our international series included 1009 probands with a known FBN1 mutation. Patients were classified as either fulfilling or not fulfilling "clinical"…

Exploring a new incubation model for FinTechs: Regulatory sandboxes

2021

Research on incubation models indicates that incubators and accelerators are crucial catalysts for the development of start-ups. To facilitate start-ups in financial markets, several regulatory authorities have adopted a new incubation model called a ‘regulatory sandbox’. Regulatory sandboxes enable eligible applicants to test their technology-enabled financial solutions for a certain period of time (subject to conditions the regulator imposes). As such, these instruments allow innovation while preventing severe instability in financial markets caused by systemic risk. Despite their importance, management research has devoted little attention to studying how sandboxes operate as a new incub…

kq-Representation for pseudo-bosons, and completeness of bi-coherent states

2017

We show how the Zak $kq$-representation can be adapted to deal with pseudo-bosons, and under which conditions. Then we use this representation to prove completeness of a discrete set of bi-coherent states constructed by means of pseudo-bosonic operators. The case of Riesz bi-coherent states is analyzed in detail.

Future Directions in the Pharmacologic Therapy of Chronic Obstructive Pulmonary Disease

2005

Current therapy for chronic obstructive pulmonary disease (COPD) fails to alter its relentless progression. This remains a significant challenge and unmet need. A recent advance is the demonstration that treatment with a fixed dose of an inhaled corticosteroid and a long-acting beta2-agonist in COPD improves lung function and quality of life, and reduces exacerbation more effectively than either drug alone. Other improvements include the introduction of tiotropium, a once-daily anticholinergic. In advanced clinical development are other once-daily bronchodilators and combinations of anticholinergic drugs and beta2-agonists. Increased understanding of the pathogenesis of COPD has led to nove…

Obstructive sleep apnoea in acute coronary syndrome.

2019

Obstructive sleep apnoea (OSA) syndrome affects about 13% of the male and 7–9% of the female population. Hypoxia, oxidative stress and systemic inflammation link OSA and cardiovascular and metabolic consequences, including coronary artery disease. Current research has identified several clinical phenotypes, and the combination of breathing disturbances during sleep, systemic effects and end-organ damage might help to develop personalised therapeutic approaches. It is unclear whether OSA is a risk factor for acute coronary syndrome (ACS) and might affect its outcome. On the one hand, OSA in patients with ACS may worsen prognosis; on the other hand, OSA-related hypoxaemia could favour the dev…

Mild obstructive sleep apnea increases hypertension risk, challenging traditional severity classification

2020

STUDY OBJECTIVES: The association of mild obstructive sleep apnea (OSA) with important clinical outcomes remains unclear. We aimed to investigate the association between mild OSA and systemic arterial hypertension (SAH) in the European Sleep Apnea Database cohort. METHODS: In a multicenter sample of 4,732 participants, we analyzed the risk of mild OSA (subclassified into 2 groups: mild(AHI 5-<11/h) (apnea-hypopnea index [AHI], 5 to <11 events/h) and mild(AHI 11-<15/h) (AHI, ≥11 to <15 events/h) compared with nonapneic snorers for prevalent SAH after adjustment for relevant confounding factors including sex, age, smoking, obesity, daytime sleepiness, dyslipidemia, chronic obstructive pulmona…

Representation Theorems for Indefinite Quadratic Forms Revisited

2010

The first and second representation theorems for sign-indefinite, not necessarily semi-bounded quadratic forms are revisited. New straightforward proofs of these theorems are given. A number of necessary and sufficient conditions ensuring the second representation theorem to hold is proved. A new simple and explicit example of a self-adjoint operator for which the second representation theorem does not hold is also provided.

A Kato's second type representation theorem for solvable sesquilinear forms

2017

Kato's second representation theorem is generalized to solvable sesquilinear forms. These forms need not be non-negative nor symmetric. The representation considered holds for a subclass of solvable forms (called hyper-solvable), precisely for those whose domain is exactly the domain of the square root of the modulus of the associated operator. This condition always holds for closed semibounded forms, and it is also considered by several authors for symmetric sign-indefinite forms. As a consequence, a one-to-one correspondence between hyper-solvable forms and operators, which generalizes those already known, is established.