Search results for "Systemic."
showing 10 items of 756 documents
Factors contributing to the variability in muscle ageing
2012
a b s t r a c t Ageing is accompanied with a progressive loss of muscle mass and force generating capacity. Ultimately, the muscle wasting and weakness may dramatically impact on mobility and the quality of life, where the elderly has increasing problems with performing activities of daily life, such as rising from a chair or climbing stairs. The rate of structural and functional deterioration of muscle appears to vary considerably between people. Part of the variation in the 'rate of muscle ageing' is attributable to genetic factors, the timing of changes in circulating hormones and the presence or absence of chronic low-grade systemic inflammation. Where an individual cannot change much i…
Scientific Instruments on Display
2016
Why and where are scientific instruments displayed? As this collective work convincingly demonstrates, the exhibition and representation of instruments depends on considerations that are shaped by ...
Rehabilitative interventions for ischaemic digital ulcers, pain, and hand functioning in systemic sclerosis: a prospective before-after study
2022
Abstract Background Systemic sclerosis (SSc) is a rare connective tissue disease characterised by immune dysfunction, vasculopathy, cellular inflammation, fibrosis of the skin associated with multiple internal organs involvement. Ischaemic digital ulcers (IDU) of the hands commonly occur in patients with SSc adversely affecting functional independence. Purpose Aim of the study is to investigate the effectiveness of a rehabilitation protocol based on the combined use of ultrasound (US) therapy and therapeutic exercise in terms of ulcers healing, pain relief, and hand functioning in patients affected by SSc with IDUs. Moreover, we also investigated the safety of the proposed intervention. Stu…
Role of Cytoreductive surgery in recurrent ovarian cancer
2010
Ovarian cancer is the leading cause of death from gynecologic malignancy in western countries, primarily because over 60% of patients with ovarian cancer will experience disease recurrence. Primary cytoreductive surgery and combination chemotherapy are the cornerstones of the initial treatment for epithelial ovarian cancer. The management of recurrent ovarian cancer is less clear than that of primary disease. The management of recurrent ovarian cancer is largely based on systemic chemotherapy, with surgery being offered only in selected individuals. Despite this, the benefits of surgery has been shown in a meta-analysis by Bristow et al. where the survival is influenced by the completeness …
Sesquilinear forms associated to sequences on Hilbert spaces
2019
The possibility of defining sesquilinear forms starting from one or two sequences of elements of a Hilbert space is investigated. One can associate operators to these forms and in particular look for conditions to apply representation theorems of sesquilinear forms, such as Kato's theorems. The associated operators correspond to classical frame operators or weakly-defined multipliers in the bounded context. In general some properties of them, such as the invertibility and the resolvent set, are related to properties of the sesquilinear forms. As an upshot of this approach new features of sequences (or pairs of sequences) which are semi-frames (or reproducing pairs) are obtained.
Low Grade Inflammation as a Common Pathogenetic Denominator in Age-Related Diseases: Novel Drug Targets for Anti-Ageing Strategies and Successful Age…
2010
Nowadays, people are living much longer than they used to do, however they are not free from ageing. Ageing, an inexorable intrinsic process that affects all cells, tissues, organs and individuals, is a post-maturational process that, due to a diminished homeostasis and increased organism frailty, causes a reduction of the response to environmental stimuli and, in general, is associated to an increased predisposition to illness and death. However, the high incidence of death due to infectious, cardiovascular and cancer diseases underlies a common feature in these pathologies that is represented by dysregulation of both instructive and innate immunity. Several studies show that a low-grade s…
Effects of Aging and Diet on Cardioprotection and Cardiometabolic Risk Markers.
2019
The prevalence of several diseases increases by age, including cardiovascular diseases, which are the leading cause of morbidity and mortality worldwide. Aging, as a complex process characterized by senescence, triggers various pathways, such as oxidative stress, systemic inflammation, metabolism dysfunction, telomere shortening, mitochondrial dysfunction and deregulated autophagy. A better understanding of the mechanisms underlying senescence may lead to the development of new therapeutic targets and strategies for age-related pathologies and extend the healthy lifespan. Modulating lifestyle risk factors and adopting healthy dietary patterns remain significant tools in delaying the aging …
Inflammation, ageing and cancer
2008
Cancer is generally recognized as an age-related disease. In fact, incidence and mortality rates of most human cancers increase consistently with age up to 90 years, but they plateau and decline thereafter. A low-grade systemic inflammation characterizes ageing and this pro-inflammatory status underlies biological mechanisms responsible for age-related inflammatory diseases. On the other hand, clinical and epidemiological studies show a strong association between chronic infection, inflammation and cancer and indicate that even in tumours not directly linked to pathogens, the microenvironment is characterized by the presence of a smouldering inflammation, fuelled primarily by stromal leukoc…
Systemic Development of Service Innovation
2015
This chapter explores the intrinsic characteristics of services and service systems and presents systemic approach to produce service innovations. The chapter consists of elaborating the characteristics of services and the principles of systemic development, discussing service matrixes, service systems, service strategies and business models, and special challenges related to the development of services and service innovations. Services are always produced in service systems consisting of combination of service personnel and information systems. Customers are involved in these systems by interacting with the front end of service organization. The key issue in service development and innovat…
Anatomia clinica del sistema articolare del piede
2006
From a semantic point of view the word “ankle” and “ankle region” are not synonyms as “ankle” identifies all the components of the ankle joint while “ankle region” identifies the ankle joint as well as every structures in the region, form the surface level to the skeletal one. The articular system of the foot is formed by thirthyfour synovial joints, seventeen of which have complementary curvilinear articular surface, the remaning seventeen having plane joints. The rounded surface joints are: the talonavicular joint (a spheroidal joint that is part of the transverse tarsal joint), the “anatomical” subtalar joint ( a saddle joint), five ellipsoid (or condylar) joints and ten, ankle and inter…