Search results for "Systems"
showing 10 items of 11952 documents
C5a complement and cytokine signaling mediate the pronociceptive effects of complex regional pain syndrome patient IgM in fracture mice.
2020
It has been proposed that complex regional pain syndrome (CRPS) is a posttraumatic autoimmune disease. Previously, we observed that B cells contribute to CRPS-like changes in a mouse tibia fracture model, and that early (12 months duration) CRPS patient IgM antibodies have pronociceptive effects in the skin and spinal cord of muMT fracture mice lacking B cells. The current study evaluated the pronociceptive effects of intraplantar or intrathecal injections of early CRPS IgM (5 µg) in muMT fracture mice. Skin and lumbar spinal cord were collected for immunohistochemistry and polymerase chain reaction analyses. Wild-type mice exhibited postfracture increases in complement component C5a and it…
The Light Side of Passwords : Turning Motivation from the Extrinsic to the Intrinsic
2019
There are many good and bad aspects to password authentication. They are mostly without cost, securing many accounts and systems, and allowing users access from anywhere in the world. However, passwords can elicit dark side phenomena, including security technostress; with many users feeling negatively towards them, as they struggle to cope with the sheer numbers required in their everyday lives. Much research has attempted to understand users’ interactions with passwords, examining the trade-off between security, memorability, user convenience, and suggesting techniques to manage them better. However, users continue to struggle. Many studies have shown that users are more concerned with goa…
Salesperson adoption and usage of mobile sales configuration tools
2018
PurposeThe purpose of this paper is to examine salespersons’ adoption and usage of mobile sales configuration tools (MSCT) and to identify areas for further development in this realm. Another objective is to offer a conceptualization of MSCT adoption.Design/methodology/approachFor this purpose, a qualitative case study approach was selected as the research method to better understand acceptance of a mobile configuration tool used by business-to-business (B2B) salespersons. Primary data were collected through semi-structured interviews, which included a series of open-ended questions to gain more detailed and contextual data.FindingsThe results obtained from the interviews indicated several …
Shared socioeconomic pathways for climate change research in Finland: co-developing extended SSP narratives for agriculture
2021
AbstractShared socioeconomic pathways (SSPs), developed at global scale, comprise narrative descriptions and quantifications of future world developments that are intended for climate change scenario analysis. However, their extension to national and regional scales can be challenging. Here, we present SSP narratives co-developed with stakeholders for the agriculture and food sector in Finland. These are derived from intensive discussions at a workshop attended by approximately 39 participants offering a range of sectoral perspectives. Using general background descriptions of the SSPs for Europe, facilitated discussions were held in parallel for each of four SSPs reflecting very different c…
Atención a la salud mental en adolescentes en conflicto con la ley: Una revisión comparativa de Brasil y España
2021
Se realizó un estudio comparativo descriptivo de las políticas de atención de salud mental dirigidas a adolescentes en conflicto con la ley en Brasil y España. Se realizaron búsquedas en las bases de datos Google Académico, Medline y Scopus utilizando dos estrategias de búsqueda integral para identificar y sintetizar la literatura. Se identificaron tres categorías principales que permiten definir y analizar las políticas de atención a la salud mental dirigidas a adolescentes en conflicto con la ley en Brasil y España: 1) modelos de atención a la salud y salud mental, 2) redes de atención a la salud mental infanto-juvenil, y 3) atención de salud mental a adolescentes en conflicto con la ley.…
CD40 activity on mesenchymal cells negatively regulates OX40L to maintain bone marrow immune homeostasis under stress conditions
2021
BackgroundWithin the bone marrow (BM), mature T cells are maintained under homeostatic conditions to facilitate proper hematopoietic development. This homeostasis depends upon a peculiar elevated frequency of regulatory T cells (Tregs) and immune regulatory activities from BM-mesenchymal stem cells (BM-MSCs). In response to BM transplantation (BMT), the conditioning regimen exposes the BM to a dramatic induction of inflammatory cytokines and causes an unbalanced T-effector (Teff) and Treg ratio. This imbalance negatively impacts hematopoiesis, particularly in regard to B-cell lymphopoiesis that requires an intact cross-talk between BM-MSCs and Tregs. The mechanisms underlying the ability of…
Analytical model for the long- distance tracer-transport in plants
2011
International audience; Recent investigations of long-distance transport in plants using non-invasive tracer techniques such as C radiolabeling monitored by positron emission tomography (PET) combined with magnetic resonance imaging (MRI) revealed the need of dedicated methods to allow a quantitative data analysis and comparison of such experiments. A mechanistic compartmental tracer transport model is presented, defined by a linear system of partial differential equations (PDEs). This model simplifies the complexity of axial transport and lateral exchanges in the transport pathways of plants (e.g. the phloem) by simulating transport and reversible exchange within three compartments using j…
Distribution patterns of phytoplankton functional groups in connected/isolated reservoirs in an urban drinking water system
2015
Eighteen reservoirs belonging to an urban drinking water system (Zhuhai city, South China) were investigated in the dry and flood seasons of 2013 to evaluate how hydrological connectivity may affect the specie richness and functional composition of phytoplankton. Eleven among the studied water bodies are connected through pipelines and seven are isolated. Twenty one phytoplankton functional groups were identified in the studied reservoirs. Cluster analysis showed that phytoplankton similarity is higher among connected reservoirs than among isolated ones. The average α-diversity is high in the connected reservoirs, but the average β-diversity is much higher in the isolated reservoirs. The hi…
A Cost-Effective Solution for Clearing High-Impedance Ground Faults in Overhead Low-Voltage Lines
2019
Downed distribution conductors in overhead distribution systems may not be a concern for equipment but greatly challenge the safety of persons, as well as the integrity of properties. Standard overcurrent protective devices may not be able to detect the magnitudes of currents resulting from high-impedance ground faults. Sophisticated relays able to detect high-impedance ground faults have been available to electric utilities. However, their implementation is rather uncommon, especially in developing countries, most likely due to their costs. In this paper, the authors formalize the problem, and propose a possible cost-effective solution for low-voltage overhead lines with neutral wire. This…
Interactive data-driven multiobjective optimization of metallurgical properties of microalloyed steels using the DESDEO framework
2023
Solving real-life data-driven multiobjective optimization problems involves many complicated challenges. These challenges include preprocessing the data, modelling the objective functions, getting a meaningful formulation of the problem, and supporting decision makers to find preferred solutions in the existence of conflicting objective functions. In this paper, we tackle the problem of optimizing the composition of microalloyed steels to get good mechanical properties such as yield strength, percentage elongation, and Charpy energy. We formulate a problem with six objective functions based on data available and support two decision makers in finding a solution that satisfies them both. To …