Search results for "Systolic function"
showing 3 items of 13 documents
Elevated end systolic function in a rat model of temporal lobe epilepsy
2018
Sudden unexpected death in epilepsy (SUDEP) is a common cause of premature death amongst epilepsy patients. It is hypothesized to result from cardiorespiratory dysfunction, but the exact aetiology is unknown. The aim of this study was to determine if functional cardiovascular alterations were present in rats with chronic epileptic behaviour. Naive control rats were compared to a rat model of temporal lobe epilepsy that was induced using a repeated low-dose kainic acid (KA) protocol. The results indicate that end-systolic volume was significantly (p=0.01) higher in the epileptic group whilst end-diastolic volume did not reach significance (p=0.08). Ejection fraction, stroke volume, cardiac o…
Short‐term changes in left and right systolic function following ferric carboxymaltose: a substudy of the Myocardial‐IRON trial
2020
Funding: This work was supported in part by an unrestricted grant from Vifor Pharma and Proyectos de Investigación de la Sección de Insuficiencia Cardiaca 2017 from Sociedad Española de Cardiología. The mechanisms underlying the beneficial effect of ferric carboxymaltose (FCM) in patients with heart failure (HF) and iron deficiency (ID) have not been completely characterized. The Myocardial-IRON trial was a double-blind, randomized trial that evaluated myocardial iron repletion following FCM vs. placebo in 53 patients with HF and ID. In this post hoc analysis, we evaluated whether treatment with FCM was associated with cardiac magnetic resonance changes in left and right ventricular functio…
Implication of anti-angiogenic VEGF-A165b in angiogenesis and systolic function after reperfused myocardial infarction
2020
Abstract Background Angiogenesis participates in re-establishing microcirculation after myocardial infarction (MI). Purpose In this study, we aim to further understand the role of the anti-angiogenic isoform vascular endothelial growth factor (VEGF)-A165b after MI and explore its potential as a co-adjuvant therapy to coronary reperfusion. Methods Two mice MI models were formed: 1) permanent coronary ligation (non-reperfused MI), 2) transient 45-min coronary occlusion followed by reperfusion (reperfused MI); in both models, animals underwent echocardiography before euthanasia at day 21 after MI induction. Serum and myocardial VEGF-A165b levels were determined. In both experimental MI models,…