Search results for "T REG"
showing 10 items of 208 documents
Multivariate standardisation for non-linear calibration range in the chemiluminescence determination of chromium.
2006
Multivariate standardisation is proposed for the successful chemiluminescence determination of chromium based on luminol-hydrogen peroxide reaction. In an extended concentration range, non-linear calibration model is needed. The studied instrumental situations were different detection cells, instruments, assemblies, time and their possible combinations. Chemiluminescence kinetic registers have been transferred using piecewise direct standardisation (PDS) method. The optimisation of transfer parameters has been carried out based on the prediction residual error criteria. Non-linear principal component regression (NL-PCR) and non-linear partial least square regression (NL-PLS) were chosen for…
Regulation of ISWI chromatin remodelling activity.
2013
The packaging of the eukaryotic genome into chromatin facilitates the storage of the genetic information within the nucleus, but prevents the access to the underlying DNA sequences. Structural changes in chromatin are mediated by several mechanisms. Among them, ATP-dependent remodelling complexes belonging to ISWI family provides one of the best examples that eukaryotic cells evolved to finely regulate these changes. ISWI-containing complexes use the energy derived from ATP hydrolysis to rearrange nucleosomes on chromatin in order to favour specific nuclear reactions. The combination of regulatory nuclear factors associated with the ATPase subunit as well as its modulation by specific histo…
Emotion dysregulation in hypochondriasis and depression
2017
Background The aim of this study was to explore whether certain aspects of emotion dysregulation (i.e., facets of alexithymia and rumination) are more closely linked to hypochondriasis than to depression and vice versa. Methods Nineteen patients with hypochondriasis (HYP), 33 patients with depression, and 52 healthy control participants completed the Toronto Alexithymia Scale, the Response Styles Questionnaire, and additional symptom and illness behaviour scales. A clinical interview was used to establish DSM-IV diagnoses and to exclude all cases with more than one axis I diagnosis. Results Depression patients reported more difficulties describing feelings and more symptom- and self-focused…
Cerebrospinal fluid T-regulatory cells recognize Borrelia burgdorferi NAPA in chronic Lyme borreliosis.
2013
The NapA protein of B. burgdorferi is essential for the persistence of spirochetes in ticks. One of the most intriguing aspects of NapA is its potential to interfere with the host immune system. Here, we investigated the role of the acquired immune responses induced by NapA in the cerebrospinal fluids (CSF) of patients with chronic Lyme borreliosis. We evaluated the cytokine profile induced in microglia cells and CSF T cells following NapA stimulation. We report here that NapA induced a regulatory T (Treg) response in the CSF of patients with chronic Lyme borreliosis and it is able to expand this suppressive response by promoting the production of TGF-β and IL-10 by microglia cells. Collect…
Increasing incidence of colorectal cancer in young adults in Europe over the last 25 years
2019
ObjectiveThe incidence of colorectal cancer (CRC) declines among subjects aged 50 years and above. An opposite trend appears among younger adults. In Europe, data on CRC incidence among younger adults are lacking. We therefore aimed to analyse European trends in CRC incidence and mortality in subjects younger than 50 years.DesignData on age-related CRC incidence and mortality between 1990 and 2016 were retrieved from national and regional cancer registries. Trends were analysed by Joinpoint regression and expressed as annual percent change.ResultsWe retrieved data on 143.7 million people aged 20–49 years from 20 European countries. Of them, 187 918 (0.13%) were diagnosed with CRC. On averag…
C4-dicarboxylate carriers and sensors in bacteria
2002
AbstractBacteria contain secondary carriers for the uptake, exchange or efflux of C4-dicarboxylates. In aerobic bacteria, dicarboxylate transport (Dct)A carriers catalyze uptake of C4-dicarboxylates in a H+- or Na+-C4-dicarboxylate symport. Carriers of the dicarboxylate uptake (Dcu)AB family are used for electroneutral fumarate:succinate antiport which is required in anaerobic fumarate respiration. The DcuC carriers apparently function in succinate efflux during fermentation. The tripartite ATP-independent periplasmic (TRAP) transporter carriers are secondary uptake carriers requiring a periplasmic solute binding protein. For heterologous exchange of C4-dicarboxylates with other carboxylic …
Peptides of the Constant Region of Antibodies Display Fungicidal Activity
2012
Synthetic peptides with sequences identical to fragments of the constant region of different classes (IgG, IgM, IgA) of antibodies (Fc-peptides) exerted a fungicidal activity in vitro against pathogenic yeasts, such as Candida albicans, Candida glabrata, Cryptococcus neoformans, and Malassezia furfur, including caspofungin and triazole resistant strains. Alanine-substituted derivatives of fungicidal Fc-peptides, tested to evaluate the critical role of each residue, displayed unaltered, increased or decreased candidacidal activity in vitro. An Fc-peptide, included in all human IgGs, displayed a therapeutic effect against experimental mucosal and systemic candidiasis in mouse models. It is in…
COVID-19 vaccination hesitancy among Ukrainians
2022
Šajā darbā tiek pētīta šaubu dinamika attiecībā uz Covid-19 vakcīnām, tās triangulējot starp trīs sfērām – personīgo, sociālo un politisko. Vakcīnu apšaubīšana tiek aplūkota plašākā kontekstā, skatot politiskā režīma maiņu Ukrainā vēsturiski izsekojot pēcpadomju periodam raksturīgas šaubas un to pastiprinājumu kopš Covid- 19 pandēmijas sākuma, kā arī šo šaubu mazināšanās kopš Krievijas-Ukrainas kara fāzes sākuma 2022. gadā. Vakcinācijas apšaubīšana aptver vakcinācijas plāna pārrunu procesus, iespējamo Covid-19 un vakcīnu riskus un ieguvumu, citu sociālo un politisko spiedienu izvērtēšanu. Šaubas par vakcīnām konceptuāli atrodas starp nevēlēšanos vakcinēties pandēmijas laikā un piekrišanu va…
The Waterfront Theorem: an integrated and creative planning approach
2016
Waterfronts are sensitive interfaces between land and sea, creative interfaces between urban and environmental components, social interfaces between nodes and networks. They not only coincide with the areas of infrastructure that are gathering on the coast, not only with the shoreline or the environmental components of the coastal territories. They are hired by the project as complex interaction of crossing flows, stratified identity of urban communities: fundamental element of the environmental system, synthesis of landscape, space and community, a place of solidification of the identity of the social, cultural and economic community (Carta, 2009). The management of urban interface of wate…
Notes per a un exemplar de La conquesta de València (València, Diego de Gumiel, 1515)
2008
En aquest treball s’ofereix una descripció de l’exemplar de l’Aureum opus regalium privilegiorum civitatis et Regni Valentiae cum historia cristianissimi Regis Iacobi ipsius primi conquistatoris conservat a la Casa del Libro (San Juan, Puerto Rico), una de les darreres aventures editorials de l’impressor Diego de Gumiel (30 d’octubre de 1515).