Search results for "T reg"

From mental hygiene to mental health: ideology, discourses and practices in Franco’s Spain (1939–75)

2017

Based on an analysis of the discourses, the ideological appropriation and the practical influence of mental hygiene in Spanish psychiatry during the early years of the Francoist regime, this article examines its decline and subsequent replacement by the new concept of mental health promoted by the World Health Organization and other international bodies from the mid-twentieth century. The old approach, essentially focused on the prophylaxis of insanity within the framework of a set of interventionist policies of social defence, was thus transformed from the beginning of the 1960s into a much more ambitious and comprehensive project which sought to promote the psychosocial balance and perfo…

Multivariate versus univariate calibration for nonlinear chemiluminescence data

2001

Abstract Multivariate calibration is tested as an alternative to model chromium(III) concentration versus chemiluminescence registers obtained from luminol-hydrogen peroxide reaction. The multivariate calibration approaches included have been: conventional linear methods (principal component regression (PCR) and partial least squares (PLS)), nonlinear methods (nonlinear variants and variants of locally weighted regression) and linear methods combined with variable selection performed in the original or in the transformed data (stepwise multiple linear regression procedure). Both the direct and inverse univariate approaches have been also tested. The use of a double logarithmic transformatio…

Ascl1 Coordinately Regulates Gene Expression and the Chromatin Landscape during Neurogenesis

2015

Summary The proneural transcription factor Ascl1 coordinates gene expression in both proliferating and differentiating progenitors along the neuronal lineage. Here, we used a cellular model of neurogenesis to investigate how Ascl1 interacts with the chromatin landscape to regulate gene expression when promoting neuronal differentiation. We find that Ascl1 binding occurs mostly at distal enhancers and is associated with activation of gene transcription. Surprisingly, the accessibility of Ascl1 to its binding sites in neural stem/progenitor cells remains largely unchanged throughout their differentiation, as Ascl1 targets regions of both readily accessible and closed chromatin in proliferatin…

Modifiable Lifestyle Factors and Cognitive Function in Older People: A Cross-Sectional Observational Study

2019

Background: The development of evidence-based interventions for delaying or preventing cognitive impairment is an important challenge. Most previous studies using self-report questionnaires face problems with reliability and consistency due to recall bias or misclassification among older people. Therefore, objective measurement of lifestyle components is needed to confirm the relationships between lifestyle factors and cognitive function. Aims: The current study examined the relationship between lifestyle factors collected with wearable sensors and cognitive function among community-dwelling older people using machine learning. Methods: In total, 855 participants (mean age: 73.8 years) wore…

Predicting bond betas using macro-finance variables

2019

We conduct in-sample and out-of-sample forecasting using the new approach of combining explanatory variables through complete subset regressions (CSR). We predict bond CAPM betas and bond returns conditioning on various macro-finance variables. We explore differences across long-term government bonds, investment grade corporate bonds, and high-yield corporate bonds. The CSR method performs well in predicting bond betas, especially in-sample, and, mainly high-yield bond betas when the focus is out-of-sample. Bond returns are less predictable than bond betas.

Fiscal multipliers and job-protection regulation

2021

Abstract We study, both theoretically and empirically, how labor market regulation affects fiscal multipliers. We focus on the stringency of employment protection legislation, a prominent source of rigidity in European labor markets. First, using a small-open economy model that features labor-market search-and-matching frictions and nominal rigidities, we show that an increase in government spending has larger output effects when firing costs are lower. The importance of layoff costs for the public spending multiplier is larger in the absence of exchange rate adjustment and in a recession. Second, we confirm these findings empirically using a panel of 26 advanced countries over the period 1…

Semisupervised nonlinear feature extraction for image classification

2012

Feature extraction is of paramount importance for an accurate classification of remote sensing images. Techniques based on data transformations are widely used in this context. However, linear feature extraction algorithms, such as the principal component analysis and partial least squares, can address this problem in a suboptimal way because the data relations are often nonlinear. Kernel methods may alleviate this problem only when the structure of the data manifold is properly captured. However, this is difficult to achieve when small-size training sets are available. In these cases, exploiting the information contained in unlabeled samples together with the available training data can si…

Somatic embryogenesis and plant regeneration from pistil transverse thin cell layers of lemon (Citrus limon)

2008

Callus induction, somatic embryogenesis and plant regeneration were obtained in Citrus limon (L.) Burm. (cv. Femminello) from cultures of pistil transverse thin cell layer explants [(t)TCLs]. Explants were cultured on two different media, based on Murashige and Skoog salts and vitamins, supplemented with 500 mg l-1 malt extract (MSI), or 500 mg l-1 malt extract and 13.3 ¼M 6-benzylaminopurine (MSII). Sucrose (146 mM) was used as carbon source. Somatic embryos appeared 3 months after culture initiation from stigma and style (t)TCLs; they were observed at the surface of the (t)TCL-derived callus. Although ovary (t)TCLs showed the highest callus formation, they never differentiated somatic emb…

Neuer Entwurf eines Credit Reglements für die Güter Besitzer in Livland: mit Erlaubniß des Herrn Civil-Gouverneurs

1802

Ville et fortifications : de l'héritage à la production du territoire urbain

2015

A large number of french cities host military historical edifices (citadels, barracks, bastions, defensive walls, etc.). Although their initial defensive functions have been lost over time, these edifices remain deeply rooted in the urban fabric of their host cities. They continue exerting an impact on these cities’ urban morphology and modern-time functions as well as the way in which the concept of city is understood. Cities nowadays face some new challenges,the increasing awareness of urban sprawl and its consequences, coupled with an urge to promote a renewed and sustainable urbanism, invites us to adopt new approaches to study urban fortifications. In addition to their symbolic aspect,…