Search results for "T-VEC"
showing 3 items of 3 documents
Oncolytic Virotherapy as Emerging Immunotherapeutic Modality: Potential of Parvovirus H-1
2014
Human tumors develop multiple strategies to evade recognition and efficient suppression by the immune system. Therefore, a variety of immunotherapeutic strategies have been developed to reactivate and reorganize the human immune system. The recent development of new antibodies against immune check points may help to overcome the immune silencing induced by human tumors. Some of these antibodies have already been approved for treatment of various solid tumor entities. Interestingly, targeting antibodies may be combined with standard chemotherapy or radiation protocols. Furthermore, recent evidence indicates that intratumoral (it) or intravenous (iv) injections of replicative oncolytic viruse…
Multidimensional Model Design using Data Mining: A Rapid Prototyping Methodology
2017
[Departement_IRSTEA]Ecotechnologies [TR1_IRSTEA]MOTIVE; International audience; Designing and building a Data Warehouse (DW), and associated OLAP cubes, are long processes, during which decision-maker requirements play an important role. But decision-makers are not OLAP experts and can find it difficult to deal with the concepts behind DW and OLAP. To support DW design in this context, we propose: (i) a new rapid prototyping methodology, integrating two different DM algorithms, to define dimension hierarchies according to decision-maker knowledge; (ii) a complete UML Profile, to define a DW schema that integrates both the DM algorithms; (iii) a mapping process to transform multidimensional …
The role of expert evaluation for microsleep detection
2015
Abstract Recently, it has been shown by overnight driving simulation studies that microsleep density is the only known sleepiness indicator which rapidly increases within a few seconds immediately before sleepiness related crashes. This indicator is based solely on EEG and EOG and subsequent adaptive pattern recognition. Accurate microsleep recognition is very important for the performance of this sleepiness indicator. The question is whether expensive evaluations of microsleep events by a) experts are necessary or b) non-experts provide sufficient evaluations. Based on 11,114 microsleep events in case a) and 12,787 in case b) recognition accuracies were investigated utilizing (i) artificia…