Search results for "TAD"

Identification and visualization of differential isoform expression in RNA-seq time series

2018

Abstract Motivation As sequencing technologies improve their capacity to detect distinct transcripts of the same gene and to address complex experimental designs such as longitudinal studies, there is a need to develop statistical methods for the analysis of isoform expression changes in time series data. Results Iso-maSigPro is a new functionality of the R package maSigPro for transcriptomics time series data analysis. Iso-maSigPro identifies genes with a differential isoform usage across time. The package also includes new clustering and visualization functions that allow grouping of genes with similar expression patterns at the isoform level, as well as those genes with a shift in major …

Viral replication modes in single-peak fitness landscapes: A dynamical systems analysis

2017

Positive-sense, single-stranded RNA viruses are important pathogens infecting almost all types of organisms. Experimental evidence from distributions of mutations and from viral RNA amplification suggest that these pathogens may follow different RNA replication modes, ranging from the stamping machine replication (SMR) to the geometric replication (GR) mode. Although previous theoretical work has focused on the evolutionary dynamics of RNA viruses amplifying their genomes with different strategies, little is known in terms of the bifurcations and transitions involving the so-called error threshold (mutation-induced dominance of mutants) and lethal mutagenesis (extinction of all sequences du…

Noninvasive ventilation for acute hypoxemic respiratory failure/ARDS: The show must go on

2018

A Stage-Based Approach to Therapy in Parkinson’s Disease

2019

Parkinson’s disease (PD) is a neurodegenerative disorder that features progressive, disabling motor symptoms, such as bradykinesia, rigidity, and resting tremor. Nevertheless, some non-motor symptoms, including depression, REM sleep behavior disorder, and olfactive impairment, are even earlier features of PD. At later stages, apathy, impulse control disorder, neuropsychiatric disturbances, and cognitive impairment can present, and they often become a heavy burden for both patients and caregivers. Indeed, PD increasingly compromises activities of daily life, even though a high variability in clinical presentation can be observed among people affected. Nowadays, symptomatic drugs and non-phar…

Bayesian approach to urinary ESBL-producing Escherichia coli

2014

This is a retrospective study about the prevalence of ESBL-producing Escherichia coli (EEC) in urinary specimens from patients from the Comunitat Valenciana from January 2007 to December 2008. Data were retrieved from RedMIVA, and Bayesian generalized linear mixed models were considered to study the prevalence of EEC with regard to demographical and microbiological factors. The total number of infections considered was 164,502, the amount of urinary isolates was 70,827 belonging to 49,304 different patients, and 5,161 (7.3%) of the urinary isolates were EEC. Three out of four E. coli were isolated in women (76.8%), men showed higher rates of EEC (9.7% in men vs. 6.5% in women). EEC patients…

Postzygotic BRAF p.Lys601Asn Mutation in Phacomatosis Pigmentokeratotica with Woolly Hair Nevus and Focal Cortical Dysplasia

2016

International audience

ACTIVIDAD FÍSICA Y DISCAPACIDAD: UN ESTUDIO CUALITATIVO CON MUJERES EN UN GIMNASIO ADAPTADO

2017

Este estudio explora cómo un grupo de mujeres con discapacidad (n=6) experimentan y perciben la práctica de actividad física en un gimnasio adaptado. Se utilizaron entrevistas semi-estructuradas como instrumento de recogida de datos cualitativos y se realizó un análisis temático inductivo. Los resultados se agruparon en torno a cuatro categorías temáticas emergentes: condición física y autonomía personal; papel paliativo del ejercicio; bienestar psicológico; relación social y apoyo. Destaca la experiencia satisfactoria de las participantes, en la que predomina una valoración positiva de procesos autorregulativos, la concepción social-relacional de la actividad física, y la relevancia del gi…

"So you're saying": the interrogation of Jordan Peterson

2021

<p class="p1">In this article, I analyse the infamous Cathy Newman interview with Jordan Peterson on the 16th of January 2018 and subsequent viewer comments on Channel 4's YouTube channel. My first hypothesis is that Newman's frequent attribution of statements to Peterson using the now notorious "so you are saying" gambit (YSG) is what triggered outrage among Peterson's followers, which, in turn, generated media interest. My second hypothesis is that the interview is best understood as a series of Face threats by Newman on Peterson using the YSG. To ascertain if my hypotheses are true, I performed corpus linguistic analyses on the interview and comments to provide objective descriptio…

If you can defend your own point of view, you're good : Norms of voice construction in student writing on an international Master's programme

2019

Abstract This ethnographically oriented study followed the writing experiences of four students on an international masters programme in Finland. Gathering a range of data, the study set out to examine what counts as good writing on a programme with a very diverse student body in which English is used as a lingua franca. Both teachers and students emphasised the importance of arguing one's ‘own point of view’ in academic writing, and teachers often formed impressions of students on the basis of their texts, drawing attention particularly to their use of metadiscourse markers (e.g., self-mentions, attitude markers and hedges). The present article therefore combines a quantitative analysis of…

Personal background, motivation and interpersonal style of psychotherapy trainees having different theoretical orientations: An Italian contribution …

2018

Background: Therapist characteristics seem to be a key factor in clinical effectiveness. Trainees’ personal and professional background, motivation, and interpersonal style have been shown to deserve attention in previous research concerning therapist development and warrant further study due to their potential implications for psychotherapy training outcomes. Aim: To explore personal and professional background, motivation, and interpersonal style of psychotherapy trainees with different theoretical approaches. Findings: In the present study, 135 post-graduate psychotherapy trainees with different theoretical approaches (psychodynamic, systemic, and cognitive-behavioral) completed the Trai…