Search results for "TAP"
showing 10 items of 2834 documents
Irregular Cytokine Pattern of CD4+T Lymphocytes in Response toStaphylococcus aureusin Patients with Wegener's Granulomatosis
1999
The initial stage of Wegener's Granulomatosis (WG) is often marked by symptoms of infection and it has been postulated that a bacterial infection could be the aetiologic factor of this disease. The objective of our work was to investigate T-cell-mediated immunity in WG by testing proliferative responses on bacterial antigens and particularly Staphylococcus aureus. We investigated the bulk proliferative response of peripheral blood lymphocytes (PBL) from patients with clinically active WG to gram-positive bacteria and purified proteinase 3 (PR-3), the major target antigen of c-ANCA. We generated S. aureus-specific PBL-derived T-cell lines and T-cell clones (TLC). In two WG patients 27 TLC we…
Single and Synergistic Effects of Type 2 Cytokines on Eosinophils and Asthma Hallmarks
2020
Abstract The type 2 cytokines IL-5, IL-13, and IL-4 play an important role in the induction and progression of asthma. According to the Global Initiative for Asthma guidelines, blood eosinophil numbers are one marker that helps to guide treatment decisions in patients suffering from severe forms of asthma. Effects of type 2 cytokines were analyzed, alone or in combination, on eosinophils in blood and other compartments and on the development of asthma symptoms. C57BL/6 mice received a single intranasal application of equimolar amounts of IL-5, IL-13, and IL-4, alone or in combination. Numbers, activation state, and migratory behavior of eosinophils in bone marrow (BM), blood, lung, and bron…
From different neurophysiological methods to conflicting pathophysiological views in migraine: a critical review of literature.
2014
Abnormal increased cortical responsivity to various types of stimuli plays a major role in migraine pathogenesis. Neurophysiological studies, however, have provided ambiguous findings of either hypo or hyper cortical excitability. This is why the term "dysexcitability" has been recently proposed to indicate a more general dysregulation of cortical excitability. The aims of this review are: (1) to provide existing knowledge and research advances in migraine pathophysiology; (2) to propose a unitary interpretation of apparently conflicting neurophysiological findings. Data of studies conducted in migraine through various evoked potentials techniques and non-invasive brain stimulation methods …
"Nainen on tyttö tarinassa." : minuuden rakentuminen Katri Tapolan romaanissa Kalpeat tytöt
2007
Vuoden 1918 sodan muistovuoden lopuksi
2018
Retoryka pamięci - wybrane problemy teoretyczne
2009
Shared socioeconomic pathways for climate change research in Finland: co-developing extended SSP narratives for agriculture
2021
AbstractShared socioeconomic pathways (SSPs), developed at global scale, comprise narrative descriptions and quantifications of future world developments that are intended for climate change scenario analysis. However, their extension to national and regional scales can be challenging. Here, we present SSP narratives co-developed with stakeholders for the agriculture and food sector in Finland. These are derived from intensive discussions at a workshop attended by approximately 39 participants offering a range of sectoral perspectives. Using general background descriptions of the SSPs for Europe, facilitated discussions were held in parallel for each of four SSPs reflecting very different c…
Pragmatics, Metaphor Studies and the Challenge of Mental Imagery
2023
Metaphor is considered a figurative use of language, a term that seems to recall the imagistic dimension characterizing this kind of utterances. Tzvetan Todorov (1967) speaks of “figure” as “visibility of speech”: as a figure, metaphor provides a kind of figurability to what is communicated. As Paul Ricoeur wrote in La métaphore vive (Ricoeur, 1975), metaphor makes “speech appear”. Precisely because of the reliance on the idea of figure, it is therefore not surprising that discussions on metaphor often refer to the role that mental images play in their comprehension. A long tradition holds that the formation of a mental image is fundamental for the comprehension of certain kinds of metaphor…
Rak - osobliwe metafory choroby
2016
W artykule zostały przedstawione metafory, jakimi obecnie posługujemy się, by opisać chorobę nowotworową. Ponieważ stała się ona chorobą publiczną i społeczną, i przestaje być tematem tabu, zatem wykreowała się wokół niej swoista metaforyka bliska terminologii wojskowej i fantastycznej. Artykuł zawiera także refleksję dotyczącą przemian w zakresie wspomnianej metaforyki i uwzględnia społeczne próby demitologizacji i złagodzenia dotychczasowego obrazu raka. Do tej pory uznawano raka za wroga, którego należy pokonać, obecnie natomiast zauważa się kuriozalną zmianę polegającą na podejmowaniu prób złagodzenia wizerunku choroby i odnajdywaniu w nim aspektów pozytywnych.
The container of my soul was severed from my shell : Metaphors of Death in Contemporary Finnish Metal Lyrics
2009
Raskaasta rockista ja metallista on tullut tänä päivänä Suomessa ainoana maana maailmassa valtavirtamusiikkia. Metallimusiikin saama suosio on tapahtunut niin nopeasti, että akateeminen maailma on vasta hiljattain havahtunut tutkimaan itse musiikkia ja ilmiötä, ja niissäkin harvoissa tapauksissa tutkimus on yleensä keskittynyt musiikin ääripäiden viittauksista ja mahdollisista yhteyksistä satanismiin tai väkivaltaiseen käytökseen. Englanninkielistä ns. ei-saatanallista metallimusiikkia on tutkittu Suomessa erittäin vähän ja tutkimuksen tarkoituksena olikin omalta osaltaan olla täyttämässä tätä tyhjiötä. Koska suurin yhteinen tekijä metallimusiikin sanoituksissa on kuolema, päädyttiin tässä…