Search results for "TARGET"
showing 10 items of 1196 documents
Evaluation of the inverse electron demand Diels-Alder reaction in rats using a scandium-44-labelled tetrazine for pretargeted PET imaging
2019
Background Pretargeted imaging allows the use of short-lived radionuclides when imaging the accumulation of slow clearing targeting agents such as antibodies. The biotin-(strept)avidin and the bispecific antibody-hapten interactions have been applied in clinical pretargeting studies; unfortunately, these systems led to immunogenic responses in patients. The inverse electron demand Diels-Alder (IEDDA) reaction between a radiolabelled tetrazine (Tz) and a trans-cyclooctene (TCO)-functionalized targeting vector is a promising alternative for clinical pretargeted imaging due to its fast reaction kinetics. This strategy was first applied in nuclear medicine using an 111In-labelled Tz to image TC…
Intervención psicológica en un equipo de gimnasia rítmica deportiva : estudio de un caso
2013
We present an intervention programme with a female rhythmic gymnastics team (N =7), with members aged 15 to 21 (M = 18, SD = 2) competing in the senior national category. Fourteen psychological group sessions were conducted between September and December 2011. The motivational climate, approaches to goals, team cohesion, the coach's leadership style and gymnasts' psychological skills were assessed before and after the intervention programme. The results showed reductions in an ego-involving climate and ego-orientation and an increase in a task-involving climate. We found changes in the leadership style of the coach, moving toward an optimal leadership profile. There was a progressive improv…
SCIROCCO tool to support knowledge transfer in integrated care
2019
Background: Knowledge transfer has been well recognised as an effective enabler to access existing evidence and learning on integrated care. It requires dedicated support to ensure that the flow of appropriate information and knowledge between adopting and transferring entities is tailored appropriately to the context and maturity of the adopting system. SCIROCCO is an online participatory tool that helps stakeholders to understand: 1) The context requirements of a particular good practice that is considered for adoption; 2) The level of maturity required for a health and social care system to adopt and scale up integrated care; 3) The actions that more progressive regions have taken to be …
TEACHER’S SELF-DEVELOPMENT: TEACHER’S SELF-DISCOVERIES REGARDING THE SIGNIFICANCE OF PEDAGOGICAL PERSONALITY DEVELOPMENT DURING PEDAGOGICAL PRACTICE
2019
In the 21st century, a special place in education is occupied by sustainable development issues, which emphasize the unique role of education in shaping the public opinion. New pedagogical approaches, which show how education could contribute to the evolution of consciousness, are being sought. A shift of paradigms is happening in education: from knowledge memorization to skills, character, meta-learning (Education 2030: Organisation for Economic Cooperation and Development competency framework). The research confirms, to successfully implement the proposed changes in modern pedagogical practice, it is valuable for the teachers to learn the psychology methods and techniques on how to improv…
Tehtäväsuuntautunut motivaatioilmasto tukee kulttuurista integraatiota
2022
Extracellular Vesicles as Biological Shuttles for Targeted Therapies.
2019
The development of effective nanosystems for drug delivery represents a key challenge for the improvement of most current anticancer therapies. Recent progress in the understanding of structure and function of extracellular vesicles (EVs)—specialized membrane-bound nanocarriers for intercellular communication—suggests that they might also serve as optimal delivery systems of therapeutics. In addition to carrying proteins, lipids, DNA and different forms of RNAs, EVs can be engineered to deliver specific bioactive molecules to target cells. Exploitation of their molecular composition and physical properties, together with improvement in bio-techniques to modify their content are critical iss…
Folate targeted coated SPIONs as efficient tool for MRI
2017
The development of more sensitive diagnostic tools allowing an early-stage and highly efficient medical imaging of tumors remains a challenge. Magnetic nanoparticles seem to be the contrast agents with the highest potential, if properly constructed. Therefore, in this study, hybrid magnetic nanoarchitectures were developed using a new amphiphilic inulin-based graft copolymer (INU-LAPEG-FA) as coating material for 10-nm spinel iron oxide (magnetite, Fe3O4) superparamagnetic nanoparticles (SPION). Folic acid (FA) covalently linked to the coating copolymer in order to be exposed onto the nanoparticle surface was chosen as the targeting agent because folate receptors are upregulated in many can…
"The world's worst cleaning lady" : the portrayal of gender in commercials targeted at American NHL audiences
2014
Mainontaan suhtaudutaan usein melko välinpitämättömästi, eikä sen vaikutusta yhteiskuntaan ja maailmankuvaamme välttämättä huomata. Mainonnan rooli vallitsevien arvojen ja ihanteiden rakentajana ja ylläpitäjänä on kuitenkin merkittävä, sillä mainonnan avulla on mahdollista tavoittaa suuri määrä ihmisiä hyvin pienessä ajassa. Kohdemainonnan avulla mainonnan viestit kohdistetaan tietylle kuluttajaryhmälle, mikä mahdollistaa mainonnan tehokkaan räätälöinnin vastaamaan kohderyhmän arvoja ja maailmankuvaa. Tämän tutkimuksen tarkoituksena oli selvittää, millaista nais- ja mieskuvaa amerikkalaisille jääkiekon katsojille suunnattu kohdemainonta välittää. Aineisto koostui 107 mainoksesta, jotka esii…
Absolute targets for HCV elimination and national health policy paradigms: Foreseeing future requirements
2021
The World Health Organization (WHO) targets for eliminating HCV by 2030 may be overambitious for many high-income countries. Recent analyses (ie, data from 2017 to 2019) show that only 11 countries are on track for meeting WHO’s elimination targets. For a country to be truly on track, it is important that the majority of infected individuals be identified and treated. There is still a need for country and population-specific evaluations within the different HCV screening and treatment strategies available, in order to assess their cost-effectiveness and sustainability and support an evidence-based policy for HCV elimination. Any health policy model is affected by the diversity and quality o…
An automatic method for metabolic evaluation of gamma knife treatments
2015
Lesion volume delineation of Positron Emission Tomography images is challenging because of the low spatial resolution and high noise level. Aim of this work is the development of an operator independent segmentation method of metabolic images. For this purpose, an algorithm for the biological tumor volume delineation based on random walks on graphs has been used. Twenty-four cerebral tumors are segmented to evaluate the functional follow-up after Gamma Knife radiotherapy treatment. Experimental results show that the segmentation algorithm is accurate and has real-time performance. In addition, it can reflect metabolic changes useful to evaluate radiotherapy response in treated patients.