Search results for "TAS2R"
showing 4 items of 14 documents
Genetic polymorphism of the bitter taste TAS2R38 gene in central Sicily
2007
Bitter taste genetics and food preference in italian population
2010
Objective: To investigate the possible role of the polymorphic bitter taste gene, TAS2R38, known to be involved in the perception of the bitter synthetic chemical phenylthiocarbamide (PTC), in influencing food preference and body mass index(BMI). Methods: up to now more than 1500 university students (17-25 years old) at Catania, Cosenza, Rome, Palermo, Pisa, Parma, Chieti, Trento University have been enrolled in the study. DNA was extracted from saliva, and genotyped by TaqMan assay for the most frequent polymorphism (PAV/AVI) of TAS2R38 gene. A possible association between genotype and food preference was assessed by administering a detailed questionnaire for food preferences and life styl…
SNP variation in the bitter taste TAS2R38 gene evaluated in student populations of several italian universities and isolates
2007
People vary widely in their sensitivities to bitter compounds, but the all intercorrelation of these sensitivities is unknown. The study of genetic influences on bitter taste perception originated from the discovery in the 1930s that some individuals had taste to phenylthiocarbamide(PTC), whereas others found it extremely bitter. Subsequently, many studies were carried out on PTC and the structurally related compound propylthiouracil (PROP) to assess this viability and to determine the root causes. Initial family studies strongly suggested that PTC no tasting was due to a recessive allele in a single gene and heritability was estimated at 0,5. 55-85% of variation in PTC detection. The PTC ge…
Saveur amère : de la molécule au comportement
2020
La saveur amère permet aux mammifères d’éviter l’ingestion d’aliments poten-tiellement contaminés par des substances amères toxiques fréquemment retrouvées dans notre environnement. La détection de ces molécules aux structures chimiques diverses est réalisée par une famille de récepteurs appelés TAS2R. L’être humain est pourvu de 25 TAS2R aux spectres de reconnaissance plus ou moins larges pour détecter un grand nombre de molécules amères. Des tests fonctionnels in vitro ont été développés afin de détermi-ner le profil d’activation des TAS2R humains. De nombreuses molécules, d’origines natu-relles ou synthétiques ont pu être identifiées comme capable d’activer ces TAS2R. Ces tests fonctionn…