Search results for "TATA"
showing 10 items of 459 documents
Value Creation and Power Asymmetries in Digital Ecosystems : A Study of a Cloud Gaming Provider
2020
Digital platforms connecting users and service providers have a central role in determining the value creation structure of ecosystems. Platform developers try to achieve a dominant position for the platform with a strong ecosystem around it. The size and attractiveness of the services can attract new users, and growing user volume can bring new co-operative service providers to the service partner network. An interesting question is how the presence of power and potential power asymmetry affect the value creation capability and the structure of a network around a platform? This chapter describes an example of value creation and the influence of power asymmetry in a digital ecosystem built …
Promoter and exon–intron structure of the protein kinase C gene from the marine sponge Geodia cydonium: evolutionary considerations and promoter acti…
1999
Abstract We report the gene structure of a key signaling molecule from a marine sponge, Geodia cydonium. The selected gene, which codes for a classical protein kinase C (cPKC), comprises 13 exons and 12 introns; the introns are, in contrast to those found in cPKC from higher Metazoa, small in size ranging from 93 nt to 359 nt. The complete gene has a length of 4229 nt and contains exons which encode the characteristic putative regulatory and catalytic domains of metazoan cPKCs. While in the regulatory domain only one intron is in phase 0, in the catalytic domain most introns are phase 0 introns, suggesting that the latter only rarely undergo module duplication. The 5′-flanking sequence of t…
Cloning and functional analyses of the mouse tapasin promoter
2003
The expression of tapasin is critical for an optimized MHC class I assembly and stable MHC class I surface expression. Thus, impaired MHC class I antigen expression of tumors can be attributable to tapasin downregulation. In order to understand the molecular mechanisms of deficient tapasin expression, the mouse tapasin promoter region and its 5'-flanking sequences were characterized. The mouse tapasin promoter lacks the TATA box and its transcription is initiated at multiple sites within a 51-nucleotide stretch. Sequence analyses revealed transcription factor binding motifs for NF-kappaB, GATA, E2F, p300, AP1, SP1 and IRF-1/2. Detailed analysis of deletion mutants and elimination of transcr…
Vuosikymmenet suomalaisen hiihtohistorian kulisseissa : tapaustutkimus vapaaehtoistoiminnan merkityksistä ja muutoksista Lahden MM-hiihdoissa
2017
Lahden Salpausselällä on pitkät perinteet pohjoismaisten hiihtolajien kilpailuareenana. Pohjoismaisten hiihtolajien MM-kilpailut on järjestetty siellä yhteensä seitsemän kertaa seitsemällä eri vuosikymmenellä. Lisäksi Lahdessa on kilpailtu vuosittain pohjoismaisten hiihtolajien maailmancupin osakilpailut, Salpausselän kisat. Kumpaakaan näistä tapahtumista ei oltaisi voitu järjestää vuosien saatossa ilman sitoutuneiden ja kokeneiden vapaaehtoisten joukkoa. Lukuisat vapaaehtoiset ovat olleet mukana kisojen vapaaehtoistoiminnassa jo useamman vuosikymmenen ajan. Tässä laadullisessa tapaustutkimuksessa selvitettiin, millaisia merkityksiä pitkään vapaaehtoisena toimineet antavat vapaaehtoistoimin…
Tajikistan: Language Situation
2006
Tajikistan, an independent Central Asian state since 1991, has Tajik, a variety of Persian, as its national language. Turkic-speaking groups, mainly Uzbeks, make up one fourth of the population. Eastern Iranian languages are still spoken in Tajikistan. Current efforts include the replacement of Russian by Tajik as the language of government and higher education as well as the reduction of Russian and Uzbek elements in Tajik.
Segmentation d'images robuste appliqué à l'imagerie par résonance magnétique et l'échographie de la prostate
2012
Prostate segmentation in trans rectal ultrasound (TRUS) and magnetic resonanceimages (MRI) facilitates volume estimation, multi-modal image registration, surgicalplaning and image guided prostate biopsies. The objective of this thesis is to developshape and region prior deformable models for accurate, robust and computationallyefficient prostate segmentation in TRUS and MRI images. Primary contributionof this thesis is in adopting a probabilistic learning approach to achieve soft classificationof the prostate for automatic initialization and evolution of a shape andregion prior deformable models for prostate segmentation in TRUS images. Twodeformable models are developed for the purpose. An…
Genome-wide analysis of factors regulating gene expression in liver
2007
In recent decades, multiple individual genes have been studied with respect to their level of expression in liver tissue and in many cases substantial progress has been made in identifying individual factors promoting gene expression in liver. However, the overall picture is still undefined and general rules or factors regulating gene expression in liver have not yet been established. Thus, a genome-wide screen for factors regulating gene expression in liver is of high interest, as it may reveal common regulatory mechanisms for most genes highly expressed in liver. These factors represent potential new targets in liver disease associated with differential gene expression. Using a novel bioi…
The Wilms' tumor suppressor gene (wt1) product regulates Dax-1 gene expression during gonadal differentiation.
1999
Gonadal differentiation is dependent upon a molecular cascade responsible for ovarian or testicular development from the bipotential gonadal ridge. Genetic analysis has implicated a number of gene products essential for this process, which include Sry, WT1, SF-1, and DAX-1. We have sought to better define the role of WT1 in this process by identifying downstream targets of WT1 during normal gonadal development. We have noticed that in the developing murine gonadal ridge, wt1 expression precedes expression of Dax-1, a nuclear receptor gene. We document here that the spatial distribution profiles of both proteins in the developing gonad overlap. We also demonstrate that WT1 can activate the D…
Different mechanisms generating sequence variability are revealed in distinct regions of the hydroxyproline-rich glycoprotein gene from maize and rel…
1992
The sequences of the genes coding for a hydroxyproline-rich glycoprotein from two varieties of maize (Zea mays, Ac1503 and W22), a teosinte (Zea diploperennis) and sorghum (Sorghum vulgare) have been obtained and compared. Distinct patterns of variability have been observed along their sequences. The 500 bp region immediately upstream of the TATA box is highly conserved in the Zea species and contains stretches of sequences also found in the sorghum gene. Further upstream, significant rearrangements are observed, even between the two maize varieties. These observations allow definition of a 5' region, which is common to the four genes and is probably essential for their expression. The 3' e…
De-demonising Japan? : Transitioning from war to peace through Japan’s cinematic post-war cultural diplomacy in UNESCO’s Orient project 1957–1959
2017
In 1959, UNESCO published a film catalogue titled Orient. A Survey of Films Produced in Countries of Arab and Asian Culture to familiarise Western audiences with Eastern cultures. Out of the 139 feature films included in the catalogue, 37 were Japanese. Through a discussion of the descriptions of the films provided in the catalogue, this article analyses Japan’s post-war cultural diplomacy in the context of the Orient project. The aim is to discuss the question of what purpose the Japanese films chosen for the Orient catalogue served in terms of cultural diplomacy. The analysis suggests the Japanese representatives aimed to position the nation in the international arena outside the Cold War…