Search results for "TAU"
showing 10 items of 4585 documents
Association Between Free-Living Sit-to-Stand Transition Characteristics, and Lower-Extremity Performance, Fear of Falling, and Stair Negotiation Diff…
2022
Abstract Background Good sit-to-stand (STS) performance is an important factor in maintaining functional independence. This study investigated whether free-living STS transition volume and intensity, assessed by a thigh-worn accelerometer, is associated with characteristics related to functional independence. Methods Free-living thigh-worn accelerometry was recorded continuously for 3–7 days in a population-based sample of 75-, 80-, and 85-year-old community-dwelling people (479 participants; women n = 287, men n = 192). The records were used to evaluate the number and intensity (angular velocity of the STS phase) of STS transitions. Associations with short physical performance battery (SPP…
Brain aging and late-onset Alzheimer's disease: many open questions.
2012
ABSTRACTDespite decades of research in the field of Alzheimer's disease (AD), a real understanding of its molecular pathophysiology and treatments relevant to the day-to-day lives of patients remain out of reach. Research has, with good reason, focused on certain key pathways and potential mechanisms, but sometimes this has been at the expense of work on other theories, which may be slowing down progress in this field. Interesting theories at present include oxidative stress and caloric restriction. Work on the Aβ cascade should continue but with a shift in focus to its intracellular effects and an awareness that additional pathogenetic factors and processes must be involved – most importan…
Alzheimer’s disease and infections, where we stand and where we go
2014
Editorial Alzheimer’s disease (AD) is a progressive neurological disorder, which represents the most common form of dementia, one of the major causes of disability in later life. Age is the greatest risk factor for AD, which typically affects people aged 65 years and over, with an age-standardised prevalence of 4.4 [1]. However, AD is not a normal part of ageing and advanced age alone does not justify the disease. Several pathways have been implicated in AD pathophysiology, the most described is the neurodegenerative one, which lead to the brain accumulation of beta-amyloid and neurofibrillary tangles, aggregations of hyperphosphorylated tau protein, macroscopically resulting in brain atrop…
2021
Introduction: Functional imaging studies have demonstrated the recruitment of additional neural resources as a possible mechanism to compensate for age and Alzheimer’s disease (AD)-related cerebral pathology, the efficacy of which is potentially modulated by underlying structural network connectivity. Additionally, structural network efficiency (SNE) is associated with intelligence across the lifespan, which is a known factor for resilience to cognitive decline. We hypothesized that SNE may be a surrogate of the physiological basis of resilience to cognitive decline in elderly persons without dementia and with age- and AD-related cerebral pathology.Methods: We included 85 cognitively normal…
Association between arterial stiffness and walking capacity in older adults
2022
Background and aim: Arterial stiffening – a process that is largely due to intimal thickening, collagen disposition or elastin fragmentation – significantly contributes to cardiovascular events and mortality. There is also some evidence that it may negatively affect physical function. This study aimed to evaluate whether arterial stiffness was associated with measures of walking capacity in a large, population-based sample of highly aged older adults.Methods: A population-based sample of 910 community-dwelling adults (aged 75, 80, or 85 years) were investigated in a cross-sectional observational study. Pulse wave velocity (PWV), a surrogate marker of arterial stiffness, was estimated based …
L'edilizia residenziale popolare della prima metà del XX secolo ad Agrigento storia e conservazione
2014
L'articolo costituisce un contributo alla conoscenza del patrimonio dell'edilizia abitativa popolare, nella prima metà del Novecento, della città di Agrigento
The Urban restoration of the Rabato-Santa Croce district in Agrigento, Sicily: Conservation, resilience and architectural morphogenesis
2015
Il saggio rappresenta un contributo al rilevante tema del restauro urbano, incentrato sulla rivitalizzazione del quartiere Rabato-Santa Croce ad Agrigento, semidistrutto da movimenti franosi nel 1966 e ancora oggi in parziale stato di abbandono. La ricerca inverte i termini del problema così come usualmente posti e non procede attraverso la somma di singole competenze specialistiche, bensì riflette su problematiche sempre diverse in relazione alle complesse implicazioni critico-estetiche e alle cangianti condizioni di conservazione. Al superamento d’una concezione tecnicistica dell’intervento, solitamente espressa dai “manuali del recupero”, segue uno sviluppo metodologico che osserva “caso…
Disvelare e conservare il palinsesto architettonico: il restauro del fronte chiaramontano nella corte interna del Collegio dei Santi Agostino e Tomma…
2020
La configurazione architettonica del Collegio dei SS. Agostino e Tommaso ad Agrigento è il risultato d’un plurisecolare processo di crescita per aggregazioni e revisioni intorno al nucleo fondativo trecentesco. La sua corte interna viene dunque a definirsi attraverso un percorso evolutivo di tipo processuale ed uno dei suoi lati mostra le tracce dell’originario palazzo Chiaramonte. Il contributo intende presentare una sintesi delle riflessioni che hanno condotto alla definizione del progetto di restauro, le matrici culturali che lo sostengono, le fasi dello studio analitico dei materiali e gli aspetti salienti del cantiere d’intervento, con particolare attenzione alla conservazione del fron…