Search results for "TAU"

Effects of phorbol 12,13-diacetate on human isolated bronchus

2000

Protein kinase C appears to be involved in the regulation of airway contractility. Phorbol 12,13-diacetate (PDA; 0.01-10 microM), a protein kinase C activator, produced a transient relaxation followed by a sustained contraction of human isolated bronchus. Different protein kinase C inhibitors (calphostin C, staurosporine and 1-(5-isoquinolinesulfonyl)-2-methylpiperazine) (H-7), nifedipine (NIF; 1 microM) or incubation with Ca(2+)-free medium, inhibited the spasmogenic response to phorbol, while ouabain (10 microM) suppressed only the initial relaxation. These results indicate that the initial relaxation, in response to PDA, is related to the activation of Na(+)/K(+)-ATPase, while the ensuin…

Psychometric evaluation of the Finnish version of the impact on participation and autonomy questionnaire in persons with multiple sclerosis

2017

Objective: The objective of this study was to evaluate the psychometric properties of the impact on participation and autonomy (IPA) questionnaire. The Finnish version of IPA (IPAFin) was translated into Finnish using the protocol for linguistic validation for patient-reported outcomes instruments. Methods: A total of 194 persons with multiple sclerosis (MS) (mean age 50 years SD 9, 72% female) with moderate to severe disability participated in this study. A confirmatory factor analysis (CFA) was used to confirm the four factor structure of the IPAFin. The work and educational opportunities domain was excluded from analysis, because it was only applicable to 51 persons. Internal consistency…

A correlative IR, MS, 1H, 13C and 15N NMR and theoretical study of 4-arylthiazol-2(3H)-onesElectronic supplementary information (ESI) available: NMR …

2002

Sixteen 4-arylthiazol-2(3H)-ones (3) were synthesised by cyclisation of α-thiocyanatoacetophenones (1) in acid solution. They appear to prefer greatly the oxo tautomeric forms. In CCl4 solution an equilibrium between the free CO bond and a “dimeric” hydrogen-bonded form exists in which the latter predominates. Several IR and NMR (1H, 13C and 15N) spectral properties are shown to correlate with Hammett σ-values and/or atomic Mulliken charges and bond orders, the latter being estimated by PM3 or AM1 semiempirical methods. The electron-impact mass spectra were also recorded and the fragmentation mechanisms interpreted in terms of the energetics of the ionic species. In addition, the geometric …

Ab initio study of the tautomeric forms of some quinolinediones

1995

Abstract 7,8-dihydroquinoline-4,5 (1 H ,6 H )-dione ( 1 ) and 7,8-dihydroquinoline-2,5-(1 H ,6 H )-dione ( 2 ) in their tautomeric oxo and hydroxy forms have been studied by ab initio Hartree-Fock calculations; tautomerization energies predict a more stable hydroxy structure having an intramolecular hydrogen bond for compound 1, whereas the oxo form is slightly-preferred for compound 2. Fourier Transform-Infra Red (FT-IR) spectra in CHCl 3 solution indicate that the predicted most stable tautomers in the vapour phase remain as such.

15N NMR studies of tautomerism

2012

The literature related to 15N NMR studies of tautomerism is updated and discussed. The 15N NMR data show that the technique is applicable for both liquid and solid state (both crystalline and amorphous) materials. Modern computational methods combined with experimental NMR data can aid in the chemical shift assignments especially in case of crystalline materials (so-called NMR crystallography). This review article is divided into chapters based on the different classes of compounds and a brief description of experimental and computational NMR techniques is also included.

ChemInform Abstract: Valence Tautomeric Interconversion in Transition Metal 1,2-Benzoquinone Complexes

2010

Lucidez intelectual

2010

Pasajes de París / 4: Sus usos culturales

2006

Teachers negotiating multilingualism in the EFL classroom

2021

Tässä artikkelissa tutkimme suomalaisten englanninopettajien käsityksiä maahanmuuttajaoppilaista, joilla on monikielinen tausta, vieraan kielen luokkahuoneessa. Aiemmat tutkimukset monikielisistä oppijoista ovat keskittyneet toisen kielen oppimiseen tai oppijan äidinkieleen. Tässä tutkimuksessa keskitymme englantiin vieraana kielenä, sillä maailma on aiempaa monikielisempi ja liikkuvuus yleisempää kuin ennen. Aineistona on englannin opettajien haastattelut (n=7), joissa he pohtivat kokemuksiaan maahanmuuttajaoppilaista vieraan kielen oppitunnilla. Analyysimenetelmänä oli laadullinen sisällönanalyysi. Tulokset osoittavat, että osallistujat eivät olleet pohtineet monikielisyyttä englannin opp…

Paradoxes of Mentoring: An Ethnographic Study of a Mentoring Programme for Highly-educated Women with Migrant Backgrounds

2019

This article explores paradoxes that emerge in the mentoring of highly-educated, female, foreign-born job-seekers in Finland. Theoretically, the study is linked to the growing body of research scrutinising the integration or discrimination of migrants in working life. It analyses cultural practices and ideas that are visible and affect the mentoring interaction. On a more practical level, the paper determines how the mentors and mentees experience the mentoring, and how intercultural mentoring could be improved in order to promote mentees’ employment. The article is based on ethnography and 11 semi-structured interviews. Two major paradoxes and their links to cultural meanings were identifi…