Search results for "TB"

RAB3GAP1 and RAB3GAP2 modulate basal and rapamycin-induced autophagy

2014

Macroautophagy is a degradative pathway that sequesters and transports cytosolic cargo in autophagosomes to lysosomes, and its deterioration affects intracellular proteostasis. Membrane dynamics accompanying autophagy are mostly elusive and depend on trafficking processes. RAB GTPase activating proteins (RABGAPs) are important factors for the coordination of cellular vesicle transport systems, and several TBC (TRE2-BUB2-CDC16) domain-containing RABGAPs are associated with autophagy. Employing C. elegans and human primary fibroblasts, we show that RAB3GAP1 and RAB3GAP2, which are components of the TBC domain-free RAB3GAP complex, influence protein aggregation and affect autophagy at basal an…

Role of medical history and medication use in the aetiology of upper aerodigestive tract cancers in Europe: the ARCAGE study

2012

ABSTRACT Background The study aimed to investigate the role of medical history (skin warts, Candida albicans, herpetic lesions, heartburn, regurgitation) and medication use (for heartburn; for regurgitation; aspirin) in the aetiology of upper aerodigestive tract (UADT) cancer. Methods A multicentre (10 European countries) case–control study [Alcohol-Related CAncers and GEnetic susceptibility (ARCAGE) project]. Results There were 1779 cases of UADT cancer and 1993 controls. History of warts or C. albicans infection was associated with a reduced risk [odds ratio (OR) 0.80, 95% confidence interval (CI) 0.68–0.94 and OR 0.73, 95% CI 0.60–0.89, respectively] but there was no association with her…

Sequential variation in genomic RNA patterns of human rotaviruses isolated from infantile gastroenteritis

1986

The incidence and RNA electrophoretypes of rotaviral isolates obtained from infants and young children with acute gastroenteritis were studied from October, 1985 through April, 1986. Analysis of the viral RNA was carried out by Polyacrylamide gel electrophoresis followed by silver staining. Fourteen electrophoretypes were identified. A single dominant electrophoretype was found during the first months of the rotavirus seasonal outbreak. In contrast, a large variety of RNA patterns were observed during the latter portion of the study period. Subgrouping of rotavirus isolates by a double-sandwich enzyme-linked immunosorbent assay using monoclonal-detecting antibodies showed that all strains b…

The COVID-19 pandemic could be a setback for gender equality in oncology-and a key moment to push ahead with transformative policies.

2021

A tale of three seasons: a cultural sport psychology and gender performativity approach to practitioner identity and development in professional foot…

2020

The present study explored how the organisational and cultural experiences of a trainee Sport Psychology Consultant (SPC) working in professional football shaped her identity and professional development. Drawing on Cultural Sport Psychology (CSP) and gender performativity as guiding frameworks, we explored the first author’s identity development as a sport psychology practitioner-researcher within one professional football club over a 3-year duration. Traditional ethnographic data collection methods were employed, including, field notes and a reflective journal. Through creative non-fiction vignettes, we show that the traditional masculine discourse in professional football shaped the firs…

Effects of population outcrossing on rotifer fitness

2010

Abstract Background Outcrossing between populations can exert either positive or negative effects on offspring fitness. Cyclically parthenogenetic rotifers, like other continental zooplankters, show high genetic differentiation despite their high potential for passive dispersal. Within this context, the effects of outcrossing may be relevant in modulating gene flow between populations through selection for or against interpopulation hybrids. Nevertheless, these effects remain practically unexplored in rotifers. Here, the consequences of outcrossing on the rotifer Brachionus plicatilis were investigated. Cross-mating experiments were performed between a reference population and three alterna…

Serological identification and expression analysis of gastric cancer-associated genes

2002

Serological identification of tumour antigens by recombinant expression cloning has proved to be an effective strategy for the identification of cancer-associated genes having a relevance to cancer aetiology and progression, and for defining possible targets for immunotherapeutic intervention. In the present study we applied this technique to identify immunogenic proteins for gastric cancer that resulted in isolation of 14 distinct serum-reactive antigens. In order to evaluate their role in tumourigenesis and assess the immunogenicity of the identified antigens, we characterised each cDNA clone by DNA sequence analysis, mRNA tissue distribution, comparison of mRNA levels in cancerous and ad…

Prácticas e identificaciones transnacionales en el fútbol europeo: un estudio referido a nueve países = Transnational practices and identifications i…

2018

Resumen: Este artículo presenta los principales hallazgos empíricos de un estudio sobre las prácticas e identificaciones de carácter transnacional que se han desarrollado en el espacio social del fútbol europeo durante las últimas décadas como consecuencia de los procesos de globalización. El objetivo del estudio ha consistido en identificar y cuantificar la emergencia de patrones de consumo e identificación que trascienden las fronteras del Estado-nación al que aquellos estuvieron confinados desde el surgimiento y desarrollo de este deporte. El sustento empírico del trabajo procede de una encuesta realizada dentro del proyecto de investigación Football Research in an Enlarged Europe (FREE)…

The use of Polar Coordinates in the analysis of motor interaction in football according to the result.

2018

The interactions of a Spanish football team of the Second A (10 official games) are analyzed, evaluating possible behavioral patterns that appear in a regular way in high level football. Observational methodology was used, by Polar Coordinates Analysis, to discover and evaluate the relationships generated between a considered focal behavior and the different conditioned categories, describing behavioral masses among the players. The matches were observed and recorded with an ad hoc observation instrument. The relations of dual character between the players taken as (focal behaviors) right midfielder and forward and the other players (conditioned conducts) were analyzed. The results show dif…

An ecological dynamics rationale to explain home advantage in professional football

2016

Despite clear findings, research on home advantage in team sports lacks a comprehensive theoretical rationale for understanding why this phenomenon is so compelling. The aim of this study was to provide an explanatory theoretical rationale in ecological dynamics for the influence of home advantage observed in research on professional football. We recorded 30 competitive matches and analyzed 13958 passes, from one highly successful team in the Portuguese Premier League, during season 2010/2011. Performance data were analyzed using the Match Analysis Software—Amisco[Formula: see text] (version 3.3.7.25), allowing us to characterize team activity profiles. Results were interpreted from an ecol…