Search results for "TBX21"

showing 3 items of 3 documents

RUNX3 and T-Bet in Immunopathogenesis of Ankylosing Spondylitis—Novel Targets for Therapy?

2019

Susceptibility to ankylosing spondylitis (AS) is polygenic with more than 100 genes identified to date. These include HLA-B27 and the aminopeptidases (ERAP1, ERAP2, and LNPEPS), which are involved in antigen processing and presentation to T-cells, and several genes (IL23R, IL6R, STAT3, JAK2, IL1R1/2, IL12B, and IL7R) involved in IL23 driven pathways of inflammation. AS is also strongly associated with polymorphisms in two transcription factors, RUNX3 and T-bet (encoded by TBX21), which are important in T-cell development and function. The influence of these genes on the pathogenesis of AS and their potential for identifying drug targets is discussed here.

lcsh:Immunologic diseases. Allergy0301 basic medicineTBX21Mini ReviewImmunologyBiologyCD8-Positive T-Lymphocytesmedicine.disease_causeAminopeptidasesInterleukin-23Polymorphism Single NucleotideAutoimmunity03 medical and health sciences0302 clinical medicineankylosing spondylitisInterleukin 23medicineImmunology and AllergyHumansImmunologic FactorsSpondylitis AnkylosingMolecular Targeted TherapyInterleukin-7 receptorTranscription factorHLA-B27 AntigenAnkylosing spondylitistherapyAntigen processingautoimmunityReceptors Interleukinmedicine.disease3. Good healthKiller Cells Natural030104 developmental biologyCore Binding Factor Alpha 3 SubunitGene Expression RegulationinflammationImmunologylcsh:RC581-607T-Box Domain ProteinsFunctional genomicsfunctional genomics030215 immunologyFrontiers in Immunology
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Partial Sleep Restriction Activates Immune Response-Related Gene Expression Pathways: Experimental and Epidemiological Studies in Humans

2013

Epidemiological studies have shown that short or insufficient sleep is associated with increased risk for metabolic diseases and mortality. To elucidate mechanisms behind this connection, we aimed to identify genes and pathways affected by experimentally induced, partial sleep restriction and to verify their connection to insufficient sleep at population level. The experimental design simulated sleep restriction during a working week: sleep of healthy men (N = 9) was restricted to 4 h/night for five nights. The control subjects (N = 4) spent 8 h/night in bed. Leukocyte RNA expression was analyzed at baseline, after sleep restriction, and after recovery using whole genome microarrays complem…

MaleTBX21NF-KAPPA-Blcsh:MedicineNK cellsBioinformaticskokeellinen tutkimusReceptors G-Protein-Coupled0302 clinical medicineCARDIOMETABOLIC RISKLeukocytesta319geeniekspressiolcsh:Scienceta515Sleep restrictionRegulation of gene expression0303 health sciencesMultidisciplinaryNATURAL-KILLERNF-kappa Bta3142Sleep in non-human animalsC-REACTIVE PROTEIN3. Good healthMACROPHAGE APOPTOSISINSUFFICIENT SLEEPSTAT1 Transcription FactorCARDIOVASCULAR-DISEASEimmuunivasteProteoglycansmedicine.symptomResearch ArticleAdulteducationENDOPLASMIC-RETICULUMMETABOLIC CONSEQUENCESSyntaxin 16Biologyepidemiologinen tutkimusuni (lepotila)03 medical and health sciencesImmune systemmedicineHumans030304 developmental biologyTOLL-LIKE RECEPTORSB cellsuniMicroarray analysis techniquesGene Expression Profilingsytokiinitlcsh:RMicroarray AnalysisGene expression profilingSleep deprivationGene Expression RegulationImmunologyRNASleep Deprivationlcsh:Q3111 BiomedicineT-Box Domain ProteinsReceptors Transforming Growth Factor beta030217 neurology & neurosurgery
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Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet.

2002

Human asthma is associated with airway infiltration by T helper 2 (TH2) lymphocytes. We observed reduced expression of the TH1 transcription factor, T-bet, in T cells from airways of patients with asthma compared with that in T cells from airways of nonasthmatic patients, suggesting that loss of T-bet might be associated with asthma. Mice with a targeted deletion of the T-bet gene and severe combined immunodeficient mice receiving CD4+cells from T-bet knockout mice spontaneously demonstrated multiple physiological and inflammatory features characteristic of asthma. Thus, T-bet deficiency, in the absence of allergen exposure, induces a murine phenotype reminiscent of both acute and chronic h…

TBX21CD4-Positive T-LymphocytesAdoptive cell transferRatónchemical and pharmacologic phenomenaMice SCIDMicemedicineAnimalsHumansLungAsthmaMice KnockoutMultidisciplinarybusiness.industryRespiratory diseaseGene targetinghemic and immune systemsT lymphocyteAllergensmedicine.diseaseAdoptive TransferAsthmarespiratory tract diseasesDisease Models AnimalCollagen Type IIIKnockout mouseImmunologyGene TargetingCytokinesInterleukin-4Bronchial HyperreactivityInterleukin-5businessT-Box Domain ProteinsBronchoalveolar Lavage FluidTranscription FactorsScience (New York, N.Y.)
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