Search results for "TC"

showing 10 items of 9993 documents

Comparison of two different techniques of fibreoptic intubation

2009

BACKGROUND AND OBJECTIVE The application of analgesics and sedatives during fibreoptic intubation (FOI) may result in a transient decrease in arterial oxygen saturation.This study evaluates two different techniques of FOI and respective effects on procedural duration, arterial oxygen saturation, and coughing by the patient. METHODS Thirty-four patients received a standardized conscious sedation with fentanyl (1.5 microg kg(-1)) and midazolam (12.5 microg kg(-1)).All patients were randomly allocated to one of the following techniques: the 'vaporization' (VAP) technique included four applications of 2 ml lidocaine 2% administered through the working channel of the fibrescope supplying an oxyg…

AdultMaleInsufflationmedicine.medical_specialtyTime FactorsAdolescentLidocainemedicine.medical_treatmentSedationConscious SedationBlood PressureFentanylFibreoptic intubationYoung AdultIntubation IntratrachealFiber Optic TechnologyHumansMedicineIntubationOxygen saturationAgedAged 80 and overbusiness.industryMiddle AgedSurgeryOxygenTreatment OutcomeAnesthesiology and Pain MedicineCoughAnesthesiaMidazolamFemalemedicine.symptombusinessmedicine.drugEuropean Journal of Anaesthesiology
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Optimized threshold for serum HCV RNA to predict treatment outcomes in hepatitis C patients receiving peginterferon alfa-2a/ribavirin

2012

It is unclear whether the current threshold for 'high' hepatitis C virus (HCV) RNA level (800,000 IU/mL) is optimal for predicting sustained virological response (SVR). We retrospectively analysed pretreatment HCV RNA levels and SVR rates in 1529 mono-infected and 176 HIV-HCV co-infected patients treated with peginterferon alfa-2a (40 kD) plus ribavirin. We improved the threshold for differentiating low and high viral load by fitting semiparametric generalized additive logistic regression models to the data and constructing receiver operating characteristics curves. Among HCV genotype 1 mono-infected patients, the difference in SVR rates between those with low and high baseline HCV RNA leve…

AdultMaleInterferon-alphaAlanine TransaminaseHepacivirusMiddle AgedViral LoadAntiviral AgentsHepatitis CRecombinant ProteinsPolyethylene GlycolsLogistic ModelsTreatment OutcomeROC CurveRibavirinHumansRNA ViralDrug Therapy CombinationFemalehepatitis CRetrospective Studies
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Safety and tolerability of slow-release oral morphine versus methadone in the treatment of opioid dependence

2014

Opioid substitution treatment (OST) for opioid dependence may be limited by adverse events (AEs). Increasing the range of therapeutic options optimizes outcomes and facilitates patient management. An international, multi-center, two-phase study investigated the efficacy and safety of slow-release oral morphine (SROM) versus methadone in patients receiving methadone therapy for opioid dependence. In phase 1 (two way cross-over, 11 weeks each period) patients were randomized to SROM or methadone oral solution. In phase 2 (25 weeks), patients continued treatment with SROM (group A) or switched from methadone to SROM (group B). In total, 211 out of 276 completed phase 1 and 198 entered phase 2 …

AdultMaleInternational CooperationAdministration OralMedicine (miscellaneous)QT intervalHeroinOpiate Substitution TreatmentHumansMedicineIn patientOral morphineAdverse effectCross-Over StudiesMorphinebusiness.industryOpioid-Related DisordersEuropePsychiatry and Mental healthClinical PsychologyTreatment OutcomeOpioidTolerabilityDelayed-Action PreparationsAnesthesiaFemalePshychiatric Mental HealthbusinessMethadonemedicine.drugMethadoneJournal of Substance Abuse Treatment
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Combined procedure for glaucoma and cataract: A retrospective study

1994

Abstract To ascertain the long-term effects of a triple procedure in the case of coexisting cataract and glaucoma, we did a retrospective study of 93 eyes that had cataract extraction, IOL implantation, and trabeculectomy within a ten-year period. Mean follow-up was 32.4 ± 21.9 months. Mean postoperative intraocular pressure (IOP) was significantly lower than preoperatively, even though fewer medications were being used. One year after surgery, 60% of eyes had a best corrected visual acuity of 20/40 or better with an average improvement of 3.8 Snellen lines. Patients who had had surgery four or more years before the study had the highest percentage of eyes with an IOP exceeding 22 mm Hg. Th…

AdultMaleIntraocular pressuremedicine.medical_specialtyAdolescentgenetic structuresmedicine.medical_treatmentEye diseaseVisual AcuityGlaucomaTrabeculectomyIntraocular lensCataract ExtractionOphthalmologymedicineHumansTrabeculectomyLongitudinal StudiesIntraocular PressureAgedRetrospective StudiesAged 80 and overLenses IntraocularBest corrected visual acuitybusiness.industryGlaucomaRetrospective cohort studyCombined procedureMiddle Agedmedicine.diseaseeye diseasesSensory SystemsSurgeryOphthalmologyTreatment OutcomeFemaleSurgerysense organsbusinessFollow-Up StudiesJournal of Cataract and Refractive Surgery
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Medium-term visual, refractive, and intraocular stability after implantation of a posterior chamber phakic intraocular lens to correct moderate to hi…

2011

To evaluate the medium-term refractive and visual outcomes and the complications after implantation of a silicone posterior chamber phakic intraocular lens (PC pIOL) for moderate to high myopia.Oftalmar, Medimar International Hospital, Alicante, Spain.Retrospective case series.Uncorrected (UDVA) and corrected (CDVA) distance visual acuities, refraction, and intraocular pressure were evaluated during a medium-term follow-up. Postoperative complications were also studied.The study enrolled 35 eyes (mean preoperative spherical equivalent [SE] -10.25 diopters [D] ± 3.19 [SD]) of 20 patients with a mean age of 31.83 ± 8.87 years and a mean follow-up of 57.34 ± 9.24 months. The mean UDVA improved…

AdultMaleIntraocular pressuremedicine.medical_specialtyPhakic Intraocular LensesVisual acuitygenetic structuresVisual AcuityPhakic intraocular lensRefraction OcularMedium termYoung AdultPostoperative ComplicationsLens Implantation IntraocularOphthalmologyMedicineHumansDioptreIntraocular PressureRetrospective Studiesbusiness.industryHigh myopiaPosterior Eye SegmentMiddle AgedRefractioneye diseasesSensory SystemsPosterior chamber phakic intraocular lensOphthalmologyTreatment OutcomeMyopia DegenerativeSurgeryFemalemedicine.symptombusinessFollow-Up StudiesJournal of cataract and refractive surgery
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A new approach based on Machine Learning for predicting corneal curvature (K1) and astigmatism in patients with keratoconus after intracorneal ring i…

2014

Keratoconus (KC) is the most common type of corneal ectasia. A corneal transplantation was the treatment of choice until the last decade. However, intra-corneal ring implantation has become more and more common, and it is commonly used to treat KC thus avoiding a corneal transplantation. This work proposes a new approach based on Machine Learning to predict the vision gain of KC patients after ring implantation. That vision gain is assessed by means of the corneal curvature and the astigmatism. Different models were proposed; the best results were achieved by an artificial neural network based on the Multilayer Perceptron. The error provided by the best model was 0.97D of corneal curvature …

AdultMaleKeratoconusgenetic structuresComputer sciencemedicine.medical_treatmentHealth InformaticsAstigmatismMachine learningcomputer.software_genreKeratoconusCorneal TransplantationMachine LearningYoung AdultCorneal ectasiaIntracorneal ringsArtificial IntelligenceProsthesis FittingmedicineHumansIn patientCorneal transplantationAgedRing (mathematics)Corneal curvaturebusiness.industryCorneal TopographyAstigmatismProstheses and ImplantsMiddle AgedDecision Support Systems ClinicalPrognosismedicine.diseaseeye diseasesComputer Science ApplicationsPatient Outcome AssessmentTreatment OutcomeFemalesense organsArtificial intelligencebusinesscomputerLENGUAJES Y SISTEMAS INFORMATICOSSoftware
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Uncommon clinical presentation of Kimura’s disease as bilateral retroauricular masses in a young Malian male: successful surgical approach.

2016

We present a case of a 27 year-old Malian male referred to our hospital for two large, painless retroauricolar masses that had appeared two years earlier. Bilateral cervical painless lymphadenopathy was present at physical examination, without any other systemic symptoms. His history was relevant for bilateral Kimura’s disease lesions resected 5 years earlier in the same locations. Lymphocytosis and a mild hypereosinophilia were found in routine blood tests, together with increased total IgE levels. After surgery, histology showed lymphoid infiltrates with reactive prominent germinal centres containing eosinophils, suggesting relapse of Kimura’s disease, in the context of nonencapsulated fi…

AdultMaleKimura diseaseCancer ResearchPhysiologyEndocrinology Diabetes and MetabolismImmunologyAngiolymphoid Hyperplasia with EosinophiliaNon-AsianFibrosisKeloid Kimura disease neck retroauricolar non-AsianTreatment OutcomeEndocrinologyOncologyRecurrenceKeloidPhysiology (medical)retroauricolarHumansImmunology and AllergyRetroauricularNeck
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Endoluminal therapy of GERD with a new endoscopic suturing device

2005

Background Endoscopic, endoluminal therapy might be an alternative treatment option in light of the costs of proton pump inhibitor therapy and possible complications after laparoscopic surgery. The aim of the current study was to assess the efficacy and the safety of a new endoluminal suture device (ESD) in pig models and humans. Secondly, 3 and 6 months' follow-ups were performed, and possible complications and their management were evaluated. Methods In the preclinical phase of the study, suturing procedures were practiced and evaluated in 8 pig models (Erlanger Endo Trainer). In the clinical phase, 20 patients with mild esophagitis, small or no hiatal hernia, and signs of abnormal acid e…

AdultMaleLaparoscopic surgerymedicine.medical_specialtyAdolescentEndoscopeManometrySwineSedationmedicine.medical_treatmentEndoscopy GastrointestinalGastric AcidHiatal herniaEsophagusPressuremedicineAnimalsHumansRadiology Nuclear Medicine and imagingmedicine.diagnostic_testbusiness.industrySuture TechniquesGastroenterologyEquipment DesignHydrogen-Ion Concentrationmedicine.diseaseEndoscopySurgeryDisease Models AnimalTreatment OutcomeTherapeutic endoscopyGastroesophageal RefluxGERDFemalemedicine.symptombusinessEsophagitisFollow-Up StudiesGastrointestinal Endoscopy
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Mechanical characteristics and fiber composition of human leg extensor muscles.

1979

To investigate the influence of skeletal muscle fiber composition on the mechanical performance of human skeletal muscle under dynamic conditions, 34 physical education students with differing muscle fiber composition (M. vastus lateralis) were used as subjects to perform maximal vertical jumps on the force-platform. Two kinds of jumps were performed: one from a static starting position (SJ), the other with a preliminary counter-movement (CMJ). The calculated mechanical parameters included height of rise of center of gravity (h), average force (F), net impulse (NI) and average mechanical power (W). It was observed that the percentage of fast twitch fibers was significantly related (p less t…

AdultMaleLegMaterials scienceFast twitch musclePhysiologyMusclesWork (physics)Public Health Environmental and Occupational HealthSkeletal muscleGeneral MedicineAnatomyImpulse (physics)Biomechanical Phenomenamedicine.anatomical_structurePhysiology (medical)medicineReaction TimeHumansOrthopedics and Sports MedicineHuman legMuscle fibreFiber compositionMechanical energyBiomedical engineeringEuropean journal of applied physiology and occupational physiology
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Predictors of weight loss after an intensive lifestyle intervention program in obese patients: a 1-year prospective cohort study.

2013

Published Version of an article in the journal: Health and Quality of Life Outcomes. Also available from the publisher at: http://dx.doi.org/10.1186/1477-7525-11-165 Open access Background Studies of lifestyle intervention programs in morbid obesity report large variations in weight loss outcomes. This is reported not only between but also within standardized programs. Such reports point to participants’ characteristics as possible predictors of this outcome. The aim of this prospective cohort study was to identify predictors of weight loss after a 1-year partly residential intensive lifestyle intervention program (ILI). Methods Morbidly obese patients (n=199), all Caucasian, 71% women, mea…

AdultMaleLifestyle interventionmedicine.medical_specialtyWeight lossType 2 diabetesCohort StudiesMorbid obesityQuality of lifeWeight lossInternal medicineOutcome Assessment Health CaremedicineHumansHealth related quality of lifeProspective StudiesProspective cohort studyLife Stylebusiness.industryNorwayPredictorsResearchPublic Health Environmental and Occupational HealthGeneral MedicineVDP::Medical disciplines: 700::Health sciences: 800AnthropometryMiddle Agedmedicine.diseaseObesityCombined Modality TherapyObesity MorbidPhysical therapyLinear ModelsFemalemedicine.symptombusinessBody mass indexRisk Reduction BehaviorCohort studyForecastingHealth and quality of life outcomes
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