Search results for "TCP"
showing 10 items of 45 documents
Metabolism of 3-hydroxychrysene by rat liver microsomal preparations
1990
3-Hydroxychrysene, a metabolite of the polycyclic aromatic hydrocarbon (PAH) chrysene, was metabolised by rat liver microsomal preparations obtained from Arochlor 1254-pretreated rats. Eight major metabolites were isolated by high performance liquid chromatography and characterised by u.v. spectroscopy and a variety of mass spectrometric techniques. The metabolites were unambiguously identified as 9-hydroxy-trans-1,2-dihydroxy-1,2-dihydrochrysene and 9-hydroxy-r-1,t-2,t-3,c-4-tetrahydroxy-1,2,3,4-tetrahydrochrysene and tentatively identified as 3-hydroxy-trans-5,6-dihydroxy-5,6-dihydrochrysene (since chrysene is a symmetrical molecule the 3- and 9-positions are equivalent), 9-hydroxy-trans-…
Biomonitoring exposure assessment to contemporary pesticides in a school children population of Spain
2013
The exposure to pesticides amongst school-aged children (6-11 years old) was assessed in this study. One hundred twenty-five volunteer children were selected from two public schools located in an agricultural and in an urban area of Valencia Region, Spain. Twenty pesticide metabolites were analyzed in children's urine as biomarkers of exposure to organophosphate (OP) insecticides, synthetic pyrethroid insecticides, and herbicides. These data were combined with a survey to evaluate the main predictors of pesticide exposure in the children's population. A total of 15 metabolites were present in the urine samples with detection frequencies (DF) ranging from 5% to 86%. The most frequently detec…
Pancreatic T cell protein-tyrosine phosphatase deficiency ameliorates cerulein-induced acute pancreatitis.
2014
Background Acute pancreatitis (AP) is a common clinical problem whose incidence has been progressively increasing in recent years. Onset of the disease is trigged by intra-acinar cell activation of digestive enzyme zymogens that induce autodigestion, release of pro-inflammatory cytokines and acinar cell injury. T-cell protein tyrosine phosphatase (TCPTP) is implicated in inflammatory signaling but its significance in AP remains unclear. Results In this study we assessed the role of pancreatic TCPTP in cerulein-induced AP. TCPTP expression was increased at the protein and messenger RNA levels in the early phase of AP in mice and rats. To directly determine whether TCPTP may have a causal rol…
Middleware for transparent TCP connection migration : masking faulty TCP-based services
2004
Masteroppgave i informasjons- og kommunikasjonsteknologi 2004 - Høgskolen i Agder, Grimstad Mission critical TCP-based services create a demand for robust and fault tolerant TCP communication. Sense Intellifield monitors drill operations on rig sites offshore. Critical TCP-based services need to be available 24 hours, 7 days a week, and the service providers need to tolerate server failure. How to make TCP robust and fault tolerant without modifying existing infrastructure like existing client/server applications, services, TCP stacks, kernels, or operating systems is the motivation of this thesis. We present a new middleware approach, first of its kind, to allow TCP-based services to survi…
A human CCT5 gene mutation causing distal neuropathy impairs hexadecamer assembly in an archaeal model
2014
Chaperonins mediate protein folding in a cavity formed by multisubunit rings. The human CCT has eight non-identical subunits and the His147Arg mutation in one subunit, CCT5, causes neuropathy. Knowledge is scarce on the impact of this and other mutations upon the chaperone's structure and functions. To make progress, experimental models must be developed. We used an archaeal mutant homolog and demonstrated that the His147Arg mutant has impaired oligomeric assembly, ATPase activity, and defective protein homeostasis functions. These results establish for the first time that a human chaperonin gene defect can be reproduced and studied at the molecular level with an archaeal homolog. The major…
A Novel CCT5 Missense Variant Associated with Early Onset Motor Neuropathy
2020
Diseases associated with acquired or genetic defects in members of the chaperoning system (CS) are increasingly found and have been collectively termed chaperonopathies. Illustrative instances of genetic chaperonopathies involve the genes for chaperonins of Groups I (e.g., Heat shock protein 60, Hsp60) and II (e.g., Chaperonin Containing T-Complex polypeptide 1, CCT). Examples of the former are hypomyelinating leukodystrophy 4 (HLD4 or MitCHAP60) and hereditary spastic paraplegia (SPG13). A distal sensory mutilating neuropathy has been linked to a mutation [p.(His147Arg)] in subunit 5 of the CCT5 gene. Here, we describe a new possibly pathogenic variant [p.(Leu224Val)] of the same subunit b…
FUZZY TCP: A PRELIMINARY STUDY
2002
Implementing efficient TCP for the Internet necessarily has to cope with the problem that the source does not know in advance which window allocation policy should be the best to use for a given network condition. In this paper, an on-line adaptive fuzzy system is used at the source in an objective to find the best possible weighted combination among the available policies.
Performance Evaluation of CANIT Algorithm in Presence of Congestion Losses
2001
In this paper, we analize by queuing-simulation CANIT (Congestion Avoidance with Normalized Interval of Time) algorithm performances in presence of congestion losses. In a former work [3], we proposed the algorithm (CANIT) for TCP (Transmission Control Protocol) congestion avoidance phase in order to improve fairness during this phase, and we showed that using CANIT algorithm in an environment without loss, instead of standard congestion avoidance algorithm improves both congestion avoidance fairness and bandwith utilization for long RTT connections. In this paper, we consider congestion losses and show that the fairness as well as the bandwith utilization are more efficient when using CANI…
Alcune considerazioni e prospettive sul ruolo della pianificazione territoriale per la valuitazione strutturale e strategica in un processo partecipa…
2005
All'interno della procedura per la formazione del Piani territoriali di coordinamento provinciale viene proposta una metodologia per la valutazione e programmazione strutturale e strategica dei servizi d'area vasta in una visione policentrica all'interno di parchi. La procedura di valutazione della domanda e dell'offerta e quindi degli scenari di programmazione territoriale vengono strutturati in una copianificazione multilivello che coinvolge secondo i principi di sussidiarietà la programmazione regionale e le scelte localizzative a livello locale all'interno di ambiti intercomunali di ottimizzazione.
Parallel Genetic Algorithms for the Tuning of a Fuzzy AQM Controller
2003
This paper presents the results of the application of a parallel Genetic Algorithm (GA) in order to design a Fuzzy Proportional Integral (FPI) controller for active queue management on Internet routers. The Active Queue Management (AQM) policies are those policies of router queue management that allow the detection of network congestion, the notification of such occurrences to the hosts on the network borders, and the adoption of a suitable control policy. Two different parallel implementations of the genetic algorithm are adopted to determine an optimal configuration of the FPI controller parameters. Finally, the results of several experiments carried out on a forty nodes cluster of workst…