Search results for "TCR"
showing 7 items of 157 documents
Isolation and characterization of microsatellite markers in the liver fluke (Fasciola hepatica)
2004
PRIMER NOTE; International audience; Six microsatellite markers were isolated from Fasciola hepatica, a re-emerging parasite that causes important veterinary and public health problems. In a sample of 52 liver flukes from a region of hyperendemicity (Bolivian Altiplano), five microsatellite were polymorphic. Our results showed that liver flukes present important genetic variability, suggesting a preferential outcrossing reproduction mode for this hermaphroditic parasite.
Aetosaur pes from the Upper Triassic of Krasiejów (Poland), with remarks on taxonomy of isolated bones
2021
The incomplete, articulated, right pes of an aetosaur, extracted from the lower bone-bearing horizon of the Krasiejów Late Triassic site, is larger than any other, known from among the Aetosauria. Its individual bones resemble those of at least three genera: Desmatosuchus (astragalus), Typothorax (ungual phalanges), and Stagonolepis (metatarsals). This underscores the highly speculative nature of the taxonomical classification of isolated postcranial bones and makes it impossible to assign the limb to any particular genus. The phalangeal formula is 2-3-4-5-?; for the fifth finger: 2/3/4 is possible. The anatomy of the pes indicates adaptation for digging.
Fosildiagénesis del anélido Rotularia spirulaea (Lamarck, 1818) (Polychaeta, Serpulidae) en el Eoceno del dominio pirenaico occidental
2018
The presence of the fossil polychaete Rotularia spirulaea (Lamarck, 1818) in Eocene deposits (middle Lutecian – upper Bartonian and (?) Priabonian) belonging to the western Pyrenean Domain is verified. In this paper, a fossildiagenetic study has been carried out. Fossils from three areas, corresponding to diff erent depositional settings, have been analysed. In area 1, sediments of the Ardanatz Sandstone and Ilundain Marls formations [Pamplona Basin and adjoining areas (Navarre)], were sampled. Here, the specimens of R. spirulaea were not substantially affected by taphonomic reworking and the original microstructure of the carbonate tube is preserved. The test consists of a thick external …
Extensional deformations during Neogene chain building in Sicily
2010
ABSTRACT In the Madonie-Nebrodi Mts (Northern Sicily belt) both Mesozoic carbonate platform/basin-derived deformed successions and Neogene foredeep deposits outcrop. Thrust sheets piled-up southwards in thin-skin piggy-back sequence. The chain building process began during the Oligo-Miocene. The syntectonic deposits involved in the compressional tectonics give evidence that syn-sedimentary extensional faults developed during fold nucleation and amplification. Syn-sedimentary extensional faults affect the foredeep strata at different stratigraphic levels, which are bounded by unconformities. Normal faults and bedding show constant cut-off relationships and are progressively tilted youngwards…
Early Jurassic (Sinemurian) gastropods from the Lusitanian Basin (west of Portugal)
2020
The Sinemurian gastropod specimens herein studied come from two sources: from museum collections and from samplings in field. The study of the Sinemurian gastropod specimens housed in the collections of the Museu Geológico (Laboratório Nacional de Energia e Geologia), Museu Nacional de História Natural e da Ciência (University of Lisbon), Museu da Ciência (University of Coimbra) and of the Museu de História Natural e da Ciência (University of Porto), has allowed the systematic and taxonomical update of this material. These specimens come mostly from Sinemurian outcrops in S. Pedro de Moel area and Coimbra region, and were collected by Paul Choffat and collaborators in the geological field w…
Identificación de TCRs reactivos contra neoantígenos tumorales en muestras de pacientes con CPNM mediante secuenciación de nueva generación. Implicac…
2021
A pesar del éxito de la inmunoterapia con los bloqueantes de los puntos del control inmune (ICBs) en el cáncer de pulmón, el porcentaje de pacientes que se beneficia de este tipo de tratamiento sigue siendo inferior al 30%, por lo que aún es necesario el desarrollo de nuevos posibles biomarcadores para una mejor selección de los pacientes. El objetivo principal del presente trabajo de tesis doctoral es caracterizar el repertorio de la cadena beta del receptor de células T (TCR-β) en sangre periférica y correlacionar con las variables demográficas, clínico-patológicas, predictivas y pronósticas en una cohorte de pacientes con cáncer de pulmón no microcítico (CPNM) en estadios avanzados trata…
La transmissió cultural a l’educació primària a través del currículum de música. Una anàlisi dels llibres de text
2016
El treball d’investigació que ací es presenta mostra una mirada des de les pedagogies crítiques i postcrítiques, entorn de la transmissió cultural que esdevé al currículum de Música d’Educació Primària del País Valencià, sent aquesta reconeguda a partir del buidatge i l’anàlisi dels llibres de text d’aquest àmbit de coneixement. Es tracta d’una investigació de caire qualitatiu, que empra l’anàlisi del contingut i del discurs com a eines metodològiques. La intenció d’aquest estudi és mostrar que a les escoles amb l'us dels llibres de text de Música, es transmete una cultura plena de presències i també absències, i aquestes han de ser reconegudes, pensades i reflexionades pel conjunt de la co…