Search results for "TETRAZINES"

showing 4 items of 4 documents

Pyrido[2’,3’:4,5]pyrrolo[2,1-d][1,2,3,5]tetrazine-4(3H)-ones, a new class of temozolomide heteroanalogues

2009

Twelve derivatives of new ring system pyrido[2’,3’:4,5]pyrrolo[2,1-d][1,2,3,5]tetrazine were prepared in good yields by reaction of 2-diazo-3-ethoxycarbonyl-pyrrolo[3,2-b]pyridine with alkyl- or aryl-isocyanates. Nine derivatives, screened by the National Cancer Institute (Bethesda, MD) for the in vitro one dose primary anticancer assay against a panel of about 60 human tumor cell lines, showed no significant activity.

3Stereochemistry21-d][1Temozolomide Mitozolomide; pyrrolo[2; 1-d][1; 2; 3; 5]tetrazinones; Antitumor activity; pyrido[2’; 3’:4; 5]pyrrolo[2; 1-d][1; 2; 3; 5]tetrazinesTemozolomide MitozolomideRing (chemistry)Medicinal chemistryD-1Tetrazinechemistry.chemical_compoundpyrido[2’PyridineAlkylchemistry.chemical_classification5]tetrazinonesOrganic Chemistrypyrrolo[23’:4Antitumor activity pyrido[2’3’:45]pyrrolo[21-d][1235]tetrazinesSettore CHIM/08 - Chimica Farmaceuticachemistry5]pyrrolo[2Microwave irradiationTemozolomide Mitozolomide pyrrolo[21-d][1235]tetrazinoneAntitumor activity5]tetrazinesArkivoc
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4-AZAINDOLE[2,1-D][1,3,5]TETRAZINE-4(3H)-ONES, A NEW CLASS OF AZOLOTETRAZINES AS POTENTIAL ANTITUMOR AGENTS

2008

AZOLOTETRAZINESSettore CHIM/08 - Chimica Farmaceutica
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3-CHLOROETHYL-PYRROLO[2,1-D][1,2,3,5]TETRAZINES: SYNTHESIS AND ANTITUMOR ACTIVITY

2011

TETRAZINES TEMOZOLOMIDE MITOZOLOMIDE ANTITUMOR ACTIVITYTETRAZINES; TEMOZOLOMIDE; MITOZOLOMIDE; ANTITUMOR ACTIVITYMITOZOLOMIDETEMOZOLOMIDETETRAZINESSettore CHIM/08 - Chimica FarmaceuticaANTITUMOR ACTIVITY
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Ortho -Functionalized Aryltetrazines by Direct Palladium-Catalyzed C−H Halogenation: Application to Fast Electrophilic Fluorination Reactions

2016

International audience; A general catalyzed direct C-H functionalization of s-tetrazines is reported. Under mild reaction conditions, N-directed ortho-C-H activation of tetrazines allows the introduction of various functional groups, thus forming carbon-heteroatom bonds: C-X (X=I, Br, Cl) and C-O. Based on this methodology, we developed electrophilic mono- and poly-ortho-fluorination of tetrazines. Microwave irradiation was optimized to afford fluorinated s-aryltetrazines, with satisfactory selectivity, within only ten minutes. This work provides an efficient and practical entry for further accessing highly substituted tetrazine derivatives (iodo, bromo, chloro, fluoro, and acetate precurso…

weak-coordinationbond fluorination412chemistry.chemical_elements-tetrazines010402 general chemistrychemistry01 natural sciences5-tetrazines[ CHIM ] Chemical SciencesCatalysisCatalysiscycloadditionsTetrazinechemistry.chemical_compoundhalogenationfluorineOrganic chemistryMolecule[CHIM]Chemical SciencesmoleculesC-H activationheterocycles010405 organic chemistryElectrophilic fluorinationHalogenationGeneral ChemistrypalladiumCombinatorial chemistry0104 chemical scienceschemistryimaging probesElectrophilecellsfluorescenceSelectivityPalladium
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