Search results for "TEV"
showing 10 items of 748 documents
Characterization of the atmospheric muon flux in IceCube
2015
Muons produced in atmospheric cosmic ray showers account for the by far dominant part of the event yield in large-volume underground particle detectors. The IceCube detector, with an instrumented volume of about a cubic kilometer, has the potential to conduct unique investigations on atmospheric muons by exploiting the large collection area and the possibility to track particles over a long distance. Through detailed reconstruction of energy deposition along the tracks, the characteristics of muon bundles can be quantified, and individual particles of exceptionally high energy identified. The data can then be used to constrain the cosmic ray primary flux and the contribution to atmospheric …
A Stevedore's protein knot.
2009
Protein knots, mostly regarded as intriguing oddities, are gradually being recognized as significant structural motifs. Seven distinctly knotted folds have already been identified. It is by and large unclear how these exceptional structures actually fold, and only recently, experiments and simulations have begun to shed some light on this issue. In checking the new protein structures submitted to the Protein Data Bank, we encountered the most complex and the smallest knots to date: A recently uncovered α-haloacid dehalogenase structure contains a knot with six crossings, a so-called Stevedore knot, in a projection onto a plane. The smallest protein knot is present in an as yet unclassified …
Systematic review of BRAF/MEK inhibitors‐induced Severe Cutaneous Adverse Reactions (SCARs)
2020
Severe cutaneous adverse reactions (SCARs) [Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), drug rash with eosinophilia and systemic syndrome (DRESS), acute generalized exanthematous pustulosis (AGEP), and generalized bullous fixed eruption (GBFE)] are severe drug reactions that often require hospitalization and could be fatal. BRAF and MEK inhibitors (BRAF/MEKi) are a standard of care in patients with BRAF-mutated metastatic melanomas. These agents are administered until disease progression or unacceptable toxicity occurs. This review has focus on BRAF/MEKi-induced SCARs. A systematic search of the following terms: 'vemurafenib', 'cobimetinib', 'dabrafenib', 'trametinib',…
Search for new particles in two-jet final states in 7 TeV proton-proton collisions with the ATLAS detector at the LHC
2010
19 páginas, 2 figuras, 1 tabla.-- et al.(ATLAS Collaboration).
A one-pot cascade to protoberberine alkaloids via Stevens rearrangement of nitrile-stabilized ammonium ylides.
2015
A facile one-pot synthesis of protoberberines from readily accessible 1,2,3,4-tetrahydroisoquinoline-1-carbonitriles and 1,2-bis(bromomethyl)arenes is described. The reaction cascade comprises four consecutive transformations, all of which can be effected under a single set of conditions. Ten protoberberines, including the alkaloids pseudopalmatine and pseudoepiberberine, were prepared in yields up to 86% according to this strategy. No chromatographic purification of the products is required, and the route is devoid of any protecting group manipulations.
ChemInform Abstract: A One-Pot Cascade to Protoberberine Alkaloids via Stevens Rearrangement of Nitrile-Stabilized Ammonium Ylides.
2015
This method gives access to quaternary protoberberines including naturally occurring pseudopalmatine (IIIf) and pseudoepiberberine (IIIg).
Notule 190-197. In MARCHETTI D. (ED): Notule pteridologiche italiche VIII (178-211).
2010
Si segnalano nuove stazioni di alcune pteridofite interessanti. È rilevante soprattutto la scoperta di Cosentinia vellea (Aiton) Tod. subsp. bivalens (Reichst.) Rivas Mart. et Salvo x C. vellea (Aiton) Tod subsp. vellea e di Dryopteris affinis (Lowe) Fraser-Jenk. subsp. affinis x D. tyrrhena Fraser-Jenk. et Reichst. Ma, su un totale di 34 taxa presi in considerazione, molti altri sono importanti.
Learning about Students’ Receiving Special Educational Support Experiences of Qualification, Socialization and Subjectification in Finnish Vocational…
2022
This paper airs the experiences of eighteen students with special educational needs completing their studies at a Finnish vocational institution, which has a mandate to provide intensive special support for the students. It contributes to the national and international discussion of education’s purposes and elaborates on students’ descriptions. The study frames a research question: To what extent are Biesta’s domains of good education—qualification, socialization, and subjectification—audible in the narratives of Finland’s VET special educational needs students? The paper adopts a narrative approach and uses narrative positioning analysis as a methodical …
Contemporary spinal cord protection during thoracic and thoracoabdominal aortic surgery and endovascular aortic repair: a position paper of the vascu…
2015
Ischaemic spinal cord injury (SCI) remains the Achilles heel of open and endovascular descending thoracic and thoracoabdominal repair. Neurological outcomes have improved coincidentially with the introduction of neuroprotective measures. However, SCI (paraplegia and paraparesis) remains the most devastating complication. The aim of this position paper is to provide physicians with broad information regarding spinal cord blood supply, to share strategies for shortening intraprocedural spinal cord ischaemia and to increase spinal cord tolerance to transitory ischaemia through detection of ischaemia and augmentation of spinal cord blood perfusion. This study is meant to support physicians cari…
Koiran ja jäniksen konnotaatiot : Roland Barthesin konnotaatiotavat Steve Purcellin Sam & Max -sarjakuvissa ja -peleissä
2010
Pro gradu -tutkielma käsittelee Roland Barthesin konnotaatiotapoja sarjakuvan ja digitaalisen pelin kontekstissa. Tutkielman kohteena on Steve Purcellin Sam & Max -sarja, joka on jatkunut 1980-luvulta nykypäivään siirtyen mediavälineestä toiseen, mutta silti alkuperäisen tekijänsä suunnittelemana. Työn aineisto käsittää alkuperäisen sarjakuvasarjan lisäksi myös vuonna 1993 julkaistun Sam & Max Hit the Road -pelin sekä 2000-luvulla julkaistun uuden pelisarjan kaksi ensimmäistä tuotantokautta. Aineisto on laaja, käsittäen yhteensä 12 peliä ja sarjakuvasarjan kokonaisuudessaan. Laajuudesta johtuen hahmojen pohjalta 1990-luvulla tehty animaatiosarja jäi tutkielman ulkopuolelle. Tutkielman analy…