Search results for "TF"

showing 10 items of 1652 documents

UNRAVELLING THE ROLES OF THE NUCLEAR PROTEIN 1 DURING ER-STRESS INDUCTION

2020

Background: NUPR1 was described as a transcriptional factor involved in the regulation of various cellular stress-response genes, playing a crucial role in the condition of the endoplasmic-reticulum (ER) stress, thus emerging as a common molecular factor of different pathologies, obesity, hepatic steatosis, and cancer. In the present work we aim to explore how NUPR1 interacts with some pivotal genes that are the major modulators of the ER stress and metabolic cell functions. In particular we investigated the biochemical and molecular effects arising from the loss of NUPR1 in ER stress physiological conditions. Methods: We used prolonged high fat diet (HFD) feeding to induce ER stress physio…

Settore MED/06 - Oncologia MedicaNuclear protein 1 P8 NUPR1 ER stress ATF6 PERK EIF2alfa cancer obesity hepatic steatosis mouse model metabolism geneSettore BIO/11 - Biologia Molecolare
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Use of tailored intraperitoneal ePTFE dual mesh in permagna inguinal hernia

2012

Here we report a case of a giant inguinoscrotal hernia in an elderly patients treated by means of an open positioning of intraperitoneal ePTFE dual mesh. In patients with giant inguinoscrotal hernia the forceful introduction of viscera in abdominal cavity and primary wall closure is burnened from respiratory complication, abdominal compartment syndrome, and defects in wound healing thus exposing the patients to further morbidity and mortality risk. The management of these patients is difficult because of the high occurrence of morbidity factors that affect the success on intervention independently of the technique of surgical repair. The tension- free technique we adopted consented us to ob…

Settore MED/18 - Chirurgia GeneralePERMAGNA INGUINAL HERNIA INTRAPERITONEAL ePTFE DUAL MESH
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USO DELLA PROTESI INTRAPERITONEALE IN PTFE IN UN GRANDE LAPAROCELE DOPO TRAPIANTO RENALE : CASE REPORT

2008

Introduzione Il caso riguarda il trattamento chirurgico con l’utilizzo di protesi intraperitoneale dual mash PTFE di un laparocele in un paziente di 55 aa sottoposto a precedente trapianto di rene. Tale complicanza derivava da un urinoma per la necrosi massiva dell’uretrere distale del graft; per cui il pz. è stato sottoposto a reintervento in 2 giornata post trapianto con ricostruzione del piano del muscolo aponeurotico. A circa un mese dal trapianto comparsa di tumefazione in sede incisionale, che rapidamente si è evoluta fino a raggiungere le caratteristiche del grande laparocele.Gli esami strumentali evidenziavano la presenza dell’omento e del piccolo intestino nel sacco erniario. Mater…

Settore MED/18 - Chirurgia Generaledual mash PTFElaparocele trapianto di rene
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USE OF INTRAPERITONEAL PTFE DUAL-MESH IN A GIANT INCISIONAL HERNIA AFTER RENAL TRANSPLANTATION: A CASE REPORT

2008

Objectives: We evaluated the incidence of incisional hernia after kidney transplantation, predisposing factors and the results of surgical repair of a giant incisional hernia by intraperitoneal PTFE dual mesh. Patients and methods: We report our experience about an incisional hernia in a 55 years male after renal transplantation treated with an intraperitoneal dual mesh prosthesis. The cause of incisional hernia was probably due to an urinoma for a total necrosis of distal graft ureter that needed to reopen in 2sd day post transplant with primary fascial approximation. Thirty days after transplantation we discovered a large incisional hernia that rapidly became monstrous with migration of o…

Settore MED/18 - Chirurgia Generaleincisional hernia kidney transplantation intraperitoneal PTFE dual mesh
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Il dynamic business modelling per lo sviluppo e la prevenzione delle crisi delle piattaforme multi-sided

2021

Over the last few decades, the sharing economy diffusion has implemented continu- ous changes in business model opportunities with multi-sided platforms (MSPs). MSPs are digital exchange platforms that connect unmatched demand and supply side participants through internet technology. Success examples of such businesses are Airbnb, Amazon, Uber, and Just Eat. How- ever, in many cases, such initiatives also experience high growth followed by a rapid failure. Due to MSPs peculiar and complex characteristics, this study suggests adopt- ing the dynamic business modeling (DBM) perspective. The DBM aims to make explicit reinforcing and balancing cause-and-effect relationships among strategic re- s…

Settore SECS-P/07 - Economia AziendaleBusiness model Performance measurement Dynamic business modeling System dynamics Multi-sided platform.MANAGEMENT CONTROL
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Supporting Multi-Sided Platform firms to maintain rapid growth (and to avoid failure) over time through a Dynamic Business Modelling approach

2020

Over the last few decades, the diffusion of the sharing economy has nurtured continuous changes in business model opportunities with multi-sided platforms (MSPs) in many industries. MSPs are digital exchange platforms aiming at connecting unmatched demand- and supply- side participants through the use of internet technology. In many cases, such start-up initiatives have led to the creation of scale-up or high-growth firms (HGFs). However, in spite of the significant contribution to both economic development and employment, current studies seem to investigate primarily in an isolated perspective HGFs, MSPs and their business model innovation (BMI). The existing literature on HGFs focuses on …

Settore SECS-P/07 - Economia Aziendalehigh-growth firms multi-sided platforms business model innovation dynamic business modelling system dynamics
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Design and analysis of discrete choice experiments for models with response time

2013

Settore SECS-S/02 - Statistica Per La Ricerca Sperimentale E TecnologicaA sector of conjoint analysis (experimental design in marketing research) is made of the so called choice experiments. In choice experiments respondents undergo a questionnaire which is nowadays mostly submitted through the internet. The questionnaire proposes to the respondent a sequence of choice sets each one including two or more profiles being a profile a specific combination of attribute levels. The respondent selects the preferred profile for each choice set. Responses given by a sample of respondents are analysed through suitable methods aimed to eventually find the best combination of attribute levels. One method of analysis adopts the Multinomial Logit (MLN) model. In this article the authors show the results of the MLN analysis compared with another model of analysis which uses an additional response which can be easily recorded by electronically submitted questionnaires. In practice modern survey platforms like “Qualtrics” (the one used for this work) can record the so called “response latency” i.e. the time taken by the respondent to make the choice and select the most preferred profile in the choice set. Thanks to a response latency model further refined in this work it is possible to deduce the relative weight of importance of the profiles for each choice set and respondent. This type of response can be used in place of the dichotomous choice variable in the MLN model. The two models and methods of analysis are deeply compared and it is critically discussed when it is better to use one or the other method. As a result a more reliable estimate of the optimal profile comes up implying lower risks for new investments and marketing decisions.
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Distance Measures for Portfolio Selection

2017

The classical Markowitz approach to the portfolio selection problem (PSP) consists of selecting the portfolio that minimises the return variance for a given level of expected return. By solving the problem for different values of this expected return we obtain the Pareto efficient frontier, which is composed of non-dominated portfolios. The final user has to discriminate amongst these points by resorting to an external criterion in order to decide which portfolio to invest in. We propose to define an external portfolio that corresponds to a desired criterion, and to assess its distance from the Markowitz frontier in market allowing for short-sellings or not. We show that this distance is ab…

Settore SECS-S/06 - Metodi mat. dell'economia e Scienze Attuariali e FinanziarieMathematical optimizationSettore INF/01 - InformaticaComputer sciencePareto principleEfficient frontierMetaheuristicVariance (accounting)Financial modelPortfolio selectionDistance measuresMultiple criteriaDecision aidSettore SECS-S/06 -Metodi Mat. dell'Economia e d. Scienze Attuariali e Finanz.Order (exchange)PortfolioExpected returnMarkowitzSettore MAT/09 - Ricerca OperativaSelection (genetic algorithm)Distance measureIndex tracking
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Discrete Time Portfolio Selection with Lévy Processes

2007

This paper analyzes discrete time portfolio selection models with Lévy processes. We first implement portfolio models under the hypotheses the vector of log-returns follow or a multivariate Variance Gamma model or a Multivariate Normal Inverse Gaussian model or a Brownian Motion. In particular, we propose an ex-ante and an ex-post empirical comparisons by the point of view of different investors. Thus, we compare portfolio strategies considering different term structure scenarios and different distributional assumptions when unlimited short sales are allowed.

Settore SECS-S/06 - Metodi mat. dell'economia e Scienze Attuariali e Finanziarieterm structureexpected utilitySubordinated Lévy models; term structure; expected utility; portfolio strategiesportfolio strategiesMultivariate normal distributionSubordinated Lévy modelsVariance-gamma distributionInverse Gaussian distributionsymbols.namesakeSettore SECS-S/06 -Metodi Mat. dell'Economia e d. Scienze Attuariali e Finanz.Discrete time and continuous timesymbolsEconometricsPortfolioSubordinated Lévy models term structure expected utility portfolio strategiesPost-modern portfolio theoryPortfolio optimizationModern portfolio theoryMathematics
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Practical Financial Optimization: A Library of GAMS Models

2010

In Practical Financial Optimization: A Library of GAMS Models, the authors provide a diverse set of models for portfolio optimization, based on the General Algebraic Modelling System. 'GAMS' consists of a language which allows a high-level, algebraic representation of mathematical models and a set of solvers --- numerical algorithms --- to solve them. The system was developed in response to the need for powerful and flexible front-end tools to manage large, real-life models. The work begins with an overview of the structure of the GAMS language, and discusses issues relating to the management of data in GAMS models. The authors provide models for mean-variance portfolio optimization which a…

Settore SECS-S/06 -Metodi Mat. dell'Economia e d. Scienze Attuariali e Finanz.Portfolio Management Financial Optimization Optimal Decisions under Uncertainty
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