Search results for "TF"
showing 10 items of 1652 documents
Rationale and evidence on the use of tocilizumab in COVID-19: a systematic review
2020
Abstract Background Tocilizumab is an IL-6 receptor-blocking agent proposed for the treatment of severe COVID-19. The aim of this systematic review was to describe the rationale for the use of tocilizumab for the treatment of COVID-19 and to summarize the available evidence regarding its efficacy and safety. Methods MEDLINE, PubMed, EMBASE, pre-print repositories (bioRxiv and medRxiv) and two trial Registries were searched for studies on the use of tocilizumab in COVID-19 or SARS-CoV-2 infection, viral pneumonia, and/or sepsis until 20th June 2020. Results We identified 3 indirect pre-clinical studies and 28 clinical studies including 5776 patients with COVID-19 (13 with a comparison group,…
CVC AND INNOVATION PERFORMANCE: THE EFFECT OF TECHNOLOGICAL DISTANCE WITH STARTUPS AND COINVESTORS
2018
Firms are increasingly opening their boundaries by engaging in corporate venture capital (CVC) programs as potential gateway into knowledge and technologies of innovative startups. By investing in promising startups across diverse industries with different technological knowledge from the knowledge base of the investing corporate, CVC programs constitute a vehicle for corporates to both exploit and explore innovation opportunities. We first examine the relationship between more explorative CVC investments portfolio and the innovation performance of the corporate. Then, we argue that when syndicating the CVC investments with a co-investor, the portfolio of syndication partners may affect the…
Information and hierarchical structure in financial markets
1999
I investigate the information content present in the time series of stock prices of a portfolio of stocks traded in a financial market. By investigating the correlation coefficient between pairs of stocks I provide a working definition of a generalized distance between the stocks of the portfolio. This generalized distance is used to obtain an ultrametric distance matrix between the stocks. The ultrametric structure of the portfolio investigated has associated a taxonomy which is meaningful from an economic point of view.
Real- and redshift-space halo clustering in $f(R)$ cosmologies
2016
We present two-point correlation function statistics of the mass and the halos in the chameleon $f(R)$ modified gravity scenario using a series of large volume N-body simulations. Three distinct variations of $f(R)$ are considered (F4, F5 and F6) and compared to a fiducial $\Lambda$CDM model in the redshift range $z \in [0,1]$. We find that the matter clustering is indistinguishable for all models except for F4, which shows a significantly steeper slope. The ratio of the redshift- to real-space correlation function at scales $> 20 h^{-1} \mathrm{Mpc}$ agrees with the linear General Relativity (GR) Kaiser formula for the viable $f(R)$ models considered. We consider three halo populations cha…
Online platforms to teach Nutrition Education to children: a non-systematic review.
2016
espanolIntroduccion: la obesidad infantil es actualmente considerada un problema a nivel global. La educacion nutricional (EN) ha sido identifi cada como un factor para prevenir el sobrepeso y la obesidad en los ninos. Durante los ultimos anos se ha incrementado el interes en metodos novedosos para ensenar este conocimiento a los ninos, especialmente a traves del uso de Internet. Objetivo: revisar y analizar la evidencia disponible con respecto a los programas de EN dirigidos a ninos a traves del uso de Internet. Resultados: se identifi caron 3 formatos para transferir EN a ninos a traves del uso de Internet: plataformas disenadas para comunicarse con otros ninos o con profesionales, plataf…
Fertility and breast cancer: A literature review of counseling, preservation options and outcomes.
2021
Fertility preservation is an important issue in breast cancer patients undergoing oncological treatment. Fertility counseling is a crucial need given the physical and psychological stress experienced by patients. Cryopreservation of mature oocytes is currently the standard fertility-preserving procedure. Other options such as ovarian tissue preservation or gonadal protection during chemotherapy are still experimental, but have proven effectiveness. Prompt referral to a fertility unit is highly recommended in order to ensure quality of care. In this article, we focus on the different strategies to preserve fertility in breast cancer patients, assessing also the safety of pregnancy and breast…
Labor Productivity Growth: Disentangling Technology and Capital Accumulation
2014
We adopt a counterfactual approach to decompose labor productivity growth into growth of Technological Productivity (TEP), growth of the capital-labor ratio and growth of Total Factor Productivity (TFP). We bring the decomposition to the data using international countrysectoral information spanning from the 1960s to the 2000s and a nonparametric generalized kernel method, which enables us to estimate the production function allowing for heterogeneity across all relevant dimensions: countries, sectors and time. As well as documenting substantial heterogeneity across countries and sectors, we nd average TEP to account for about 44% of labor productivity growth and TEP gaps with respect to the…
Portfolio diversification in the sovereign credit swap markets
2018
We develop models for portfolio diversification in the sovereign credit default swaps (CDS) markets and show that, despite literature findings that sovereign CDS spreads are affected by global factors, there is sufficient idiosyncratic risk to be diversified. However, we identify regime switching in the times series of CDS spreads and spread returns, and the optimal diversified strategies can be regime dependent. The developed models trade off the CVaR risk measure against expected return, consistently with the statistical properties of spreads. We consider three investment strategies suited for different CDS market participants: for investors with long positions, speculators that hold unco…
Relations entre les variations climatiques, les perturbations du cycle du carbone et les crises de la production carbonatée : application au Crétacé …
2011
The Early Cretaceous is punctuated by carbon cycle perturbations, associated with organic matter burial episodes and carbonate production crises. These events coincide with short-term cooling (<1Ma), yet the mechanisms are still unclear, because of low resolution in sea surface temperature reconstructions. Recent climatic models suggest that carbonate-platform-collapse events may trigger a short-term ocean cooling episode (Donnadieu et al., accepted). In order to establish relations between climates and carbonate productions, we performed stratigraphic, palaeoecologic and geochemical analyses on Valanginian sediments from the La Charce-Vergol and the Ollioules sections (South-East France) a…
Determinants of complementary feeding practices in infants from the ELFE study : familial health, socio-economic and demographic characteristics and …
2018
Infant feeding practices could be risk factors for cardiovascular diseases, via early nutritional programming. These practices have not been described in detail in France until now and knowing their determinants could help improve nutritional prevention interventions.For more than 11 000 children followed in the ELFE cohort (French Longitudinal Study since childhood), we calculated the age at introduction of complementary feeding (CFg) and of food groups, evaluated the uses of added sugar, salt and fat from 3 to 10 months old, and defined three principal components of early feeding. Their associations with familial characteristics were evaluated, taking in account the influence of the infan…