Search results for "TG"
showing 10 items of 2275 documents
Three dimensional reconstruction to visualize atrial fibrillation activation patterns on curved atrial geometry
2021
BackgroundThe rotational activation created by spiral waves may be a mechanism for atrial fibrillation (AF), yet it is unclear how activation patterns obtained from endocardial baskets are influenced by the 3D geometric curvature of the atrium or ‘unfolding’ into 2D maps. We develop algorithms that can visualize spiral waves and their tip locations on curved atrial geometries. We use these algorithms to quantify differences in AF maps and spiral tip locations between 3D basket reconstructions, projection onto 3D anatomical shells and unfolded 2D surfaces.MethodsWe tested our algorithms in N = 20 patients in whom AF was recorded from 64-pole baskets (Abbott, CA). Phase maps were generated by…
Cell Contact–Dependent Priming and Fc Interaction with CD32+ Immune Cells Contribute to the TGN1412-Triggered Cytokine Response
2014
Abstract Following inconspicuous preclinical testing, the superagonistic anti-CD28 mAb TGN1412 was applied to six study participants who all developed a devastating cytokine storm. We verified that TGN1412 treatment of fresh PBMCs induced only moderate responses, whereas restoration of tissue-like conditions by high-density preculture (HDC) allowed vigorous cytokine production. TGN1412 treatment of T cells isolated from HDC-PBMCs induced moderate cytokine responses, which upon additional anti-IgG crosslinking were significantly boosted. Moreover, coincubation of TGN1412-treated T cells with B cells expressing the intermediate affinity Fcγ receptor IIB (CD32B), or coincubation with CD32B+ tr…
Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950–2019: a…
2020
Background Accurate and up-to-date assessment of demographic metrics is crucial for understanding a wide range of social, economic, and public health issues that affect populations worldwide. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 produced updated and comprehensive demographic assessments of the key indicators of fertility, mortality, migration, and population for 204 countries and territories and selected subnational locations from 1950 to 2019. Methods 8078 country-years of vital registration and sample registration data, 938 surveys, 349 censuses, and 238 other sources were identified and used to estimate age-specific fertility. Spatiotemporal Gaussian…
Genetic and Environmental Influences Underlying Externalizing Behaviors, Cigarette Smoking and Illicit Drug Use Across Adolescence
2012
We investigated genetic and environmental influences common to adolescent externalizing behavior (at age 12), smoking (at age 14) and initiation of drug use (at age 17) using the FinnTwin12 cohort data. Multivariate Cholesky models were fit to data from 737 monozygotic and 722 dizygotic twin pairs. Heritability of externalizing behavior was 56%, that of smoking initiation/amount 20/32%, and initiation of drug use 27%. In the best-fitting model common environmental influences explained most of the covariance between externalizing behavior and smoking initiation (69%) and amount (77%). Covariance between smoking initiation/amount and drug use was due to additive genetic (42/22%) and common en…
Hermann weyl, the reluctant revolutionary
2003
“Brouwer – that is the revolution!” – with these words from his manifesto “On the New Foundations Crisis in Mathematics” (Weyl 1921) Hermann Weyl jumped headlong into ongoing debates concerning the foundations of set theory and analysis. His decision to do so was not taken lightly, knowing that this dramatic gesture was bound to have immense repercussions not only for him, but for many others within the fragile and politically fragmented European mathematical community. Weyl felt sure that modern mathematics was going to undergo massive changes in the near future. By proclaiming a “new” foundations crisis, he implicitly acknowledged that revolutions had transformed mathematics in the past, …
Outgassing of Mantle Volatiles in Compressional Tectonic Regime Away From Volcanism: The Role of Continental Delamination
2019
In this study we discuss the occurrence of mantle-derived heat and volatiles (i.e., helium and CO 2 ) feeding hydrothermal systems in a seismically active margin between two convergent plates (African and European) without any signals of volcanism. The helium (He) isotopes clearly indicate a mantle-derived component in the outgassing volatiles. The estimated mantle-derived He fluxes are up to two to three orders of magnitude greater than those in a stable continental area. Such high He fluxes cannot be provided by a long-lasting diffusion, thereby implying a more efficient transport (i.e., advective transport through faults). He data coupled to heat-He relationship suggest the occurrence of…
Linguistic Therapy of Evaluation
2006
The linguistic therapy of evaluation (LTE) comes from the theory of general semantics (GS) developed by Alfred Korzybski. GS emphasizes the role that language plays in evaluating the world of “events,” that is, what is going on (WIGO in the individual’s world). GS is the science of both evaluation and values. “Evaluation” implies that a similar degree of importance is given to thinking and feeling. When evaluating an experience, we construe the world through language. Korzybski (1933, p. 24) defined a semantic reaction as “the psychological reaction of a given individual to words, language, symbols, and events, in connection with their meanings, and the psychological reactions, which become…
Relacion de las festivas aclamaciones, con que celebró ... Valencia la noticia de los ... Desposorios de ... Don Carlos Sebastian de Borbon y Farnes…
1738
Sig. A-E4 Capital grav. Sig. A-E4. - Sense port. - Reclams
A stalactite record of four relative sea-level highstands during the Middle Pleistocene Transition
2017
International audience; Ice-sheet and sea-level fluctuations during the Early and Middle Pleistocene are as yet poorly understood. A stalactite from a karst cave in North West Sicily (Italy) provides the first evidence of four marine inundations that correspond to relative sea-level highstands at the time of the Middle Pleistocene Transition. The speleothem is located ∼97 m above mean sea level as result of Quaternary uplift. Its section reveals three marine hiatuses and a coral overgrowth that fixes the age of final marine ingression at 1.124 ± 0.2, thus making this speleothem the oldest stalactite with marine hiatuses ever studied to date. Scleractinian coral species witness light-limited…
Legal and forensic psychology in Spain: A study of official masters and degrees in Spanish universities
2018
[ES]: La disparidad de áreas de la Psicología Jurídica requiere de una formación especializada. La formación de posgrado a través de la oferta de másteres oficiales y títulos propios posibilita una formación de calidad en esta área. Actualmente existen 4 másteres oficiales y 11 másteres propios, repartidos en universidades por todo el territorio español y abarcan gran parte de las áreas de intervención del psicólogo jurídico y forense. Mientras que los másteres oficiales cuentan con un número similar de créditos, principalmente de naturaleza presencial y con prácticas obligatorias, en los másteres de títulos propios los créditos varían de 60 a 80 créditos, con escasa capacidad optativa, pre…