Search results for "THD"
showing 10 items of 129 documents
Norepinephrine transporter gene polymorphism is not associated with susceptibility to alcohol dependence
2002
Abnormalities in monoamine neurotransmission have been implicated in the pathogenesis of alcoholism, mood disorders and schizophrenia. Murine norepinephrine transporter gene (NET) has been mapped to a region on chromosome 8 where a quantitative trait locus for ethanol sensitivity. Therefore we tested whether norepinephrine transporter (NET) gene variants confer susceptibility to either alcohol dependence or severe alcohol withdrawal symptoms. There is a highly polymorphic silent G1287A mutation in the NET gene. In our study 157 alcoholics and 185 healthy unrelated matched control subjects were analyzed for a silent G1287A mutation. No significant differences in allele and genotype distribut…
Il ruolo del Consiglio europeo nella Brexit
2019
Il Consiglio europeo ha svolto un ruolo di primo piano nella Brexit. L’articolo cerca di spiegare che questo ruolo è stato più ampio rispetto a quello espressamente conferito dall’art. 50 TUE per affrontare poi due problemi: nello svolgere questo ruolo il Consi- glio europeo ha agito solo come istituzione dell’Unione europea o anche come vertice di capi Stato? E ha rispettato il principio dell’equilibrio istituzionale? The European Council has been playing a leading role in Brexit procedure. This article aims at showing how this role does not simply reflect the powers explicitly assigned to the European Council under Article 50 TEU. Two more questions are addressed: In performing its role h…
Withholding or withdrawing of life-sustaining therapy in older adults (≥ 80 years) admitted to the intensive care unit
2018
PURPOSE: To document and analyse the decision to withhold or withdraw life-sustaining treatment (LST) in a population of very old patients admitted to the ICU. METHODS: This prospective study included intensive care patients aged ≥ 80 years in 309 ICUs from 21 European countries with 30-day mortality follow-up. RESULTS: LST limitation was identified in 1356/5021 (27.2%) of patients: 15% had a withholding decision and 12.2% a withdrawal decision (including those with a previous withholding decision). Patients with LST limitation were older, more frail, more severely ill and less frequently electively admitted. Patients with withdrawal of LST were more frequently male and had a longer ICU len…
γ1- and γ2-melanocyte stimulating hormones induce central anxiogenic effects and potentiate ethanol withdrawal responses in the elevated plus-maze te…
2008
Little is known about the endogenous functions of gamma1- and gamma2-melanocyte stimulating hormones (gamma1- and gamma2-MSH). Although gamma-MSHs bind to melanocortin receptor subtypes 3 and 4, we have previously shown that these peptides also influence non-melanocortinergic processes, such as dopaminergic and GABAergic. The aim of this study was to determine the effects of gamma1- and gamma2-MSH (at doses 0.3, 1 and 2 nmol/mouse/5 microl) on the anxiety levels in mice in elevated plus maze. Three experimental paradigms were performed to assess the effects of peptides on: a) ethanol withdrawal; b) acute ethanol-induced anxiolytic action; c) peptides per se. We used ethanol as the model sub…
Nie bij, nie krzycz... O przemocy wobec osób starszych - przegląd badań
2020
W artykule poruszono kwestie dotyczące stosowania przemocy wobec osób starszych. Zjawisko to staje się jednym z głównych problemów społecznych, z którymi muszą zmierzyć się m.in. pracownicy socjalni oraz specjaliści z zakresu pedagogiki (w tym gerontopedagogiki), socjologii, a także przedstawiciele służb pomocowych. Jak wynika z analizy danych statystycznych oraz wyników badań naukowych, skala stosowania przemocy stale się pogłębia. W opracowaniu zaprezentowano przegląd badań dotyczących skali i determinantów stosowania przemocy wobec seniorów oraz koncepcje wycofania moralnego jako jednego z czynników wywołujących zachowania przemocowe.
Withdrawal reflex organisation to electrical stimulation of the dorsal foot in humans.
2001
The present study investigated excitatory reflex receptive fields for various muscle reflex responses and reflex mediated ankle joint movements using randomised electrical stimulation of the dorsal and plantar surface of the foot in 12 healthy subjects. Eleven electrodes (0.5-cm2 cathodes) were mounted on the dorsal side and three on the plantar side of the foot. A low (1.5 times pain threshold) and a high (2.3 times pain threshold) stimulus intensity were used to elicit the reflexes. EMG signals were recorded from tibialis anterior (TA), gastrocnemius medialis (GM), soleus (SO), biceps femoris (BF), and rectus femoris (RF) muscles together with the ankle movement measured by a goniometer. …
The Effects of Transcutaneous Spinal Direct Current Stimulation on Neuropathic Pain in Multiple Sclerosis: Clinical and Neurophysiological Assessment
2019
Background: Central neuropathic pain represents one of the most common symptoms in multiple sclerosis (MS) and it seriously affects quality of life. Spinal mechanisms may contribute to the pathogenesis of neuropathic pain in MS. Converging evidence from animal models and neurophysiological and clinical studies in humans suggests a potential effect of transcranial direct current stimulation (tc-DCS) on neuropathic pain. Spinal application of DCS, i.e., transcutaneous spinal DCS (ts-DCS), may modulate nociception through inhibition of spinal reflexes. Therefore, ts-DCS could represents an effective, safe and well-tolerated treatment for neuropathic pain in MS, a largely unexplored topic. This…
Influence of the suspension of continued treatment with flurazepam and amobarbital on two discrimination learning schedules.
1977
The authors have studied the effect of the suspension of chronic treatment with flurazepam and amobarbital on the operant behavior of rats that for the first time were in the presence of two fixed-interval discrimination schedules. With the sound discrimination schedule, the responses emitted by the treated animals had characteristics similar to those of control animals. With the temporal discrimination schedule, though it is not possible to distinguish between learning rates, modifications in the intensity of the effect (increases in lever pressing) indicate that, considering the doses, the action of flurazepam is slight and that of amobarbital clear and statistically significant.
Sepsis in head and neck cancer patients treated with chemotherapy and radiation: literature review and consensus
2015
Abstract: The reporting of infection/sepsis in chemo/radiation-treated head and neck cancer patients is sparse and the problem is underestimated. A multidisciplinary group of head and neck cancer specialists from Italy met with the aim of reaching a consensus on a clinical definition and management of infections and sepsis. The Delphi appropriateness method was used for this consensus. External expert reviewers then evaluated the conclusions carefully according to their area of expertise. The paper contains seven clusters of statements about the clinical definition and management of infections and sepsis in head and neck cancer patients, which had a consensus. Furthermore, it offers a revie…
Mathematical formulation of pulse amplitude modulation selective harmonic elimination in multilevel three phase inverters
2022
In this paper multilevel cascaded H-bridges (CHB) three phase inverters with 2n dc sources, n=1,2,3,... are considered and a mathematical formulation providing both 2n switching angles and dc voltage source to eliminate n+1 harmonics and their respective multiple from their output voltage waveform, is proposed. The computed angles don't depend on modulation index and the source voltages linearly vary with it. The proposed procedure finds the solution through an analytical formula that avoids to solve transcendental systems and presents very low computational cost. A lot of low order harmonics are eliminated, returning a very low total harmonic distortion (THD). Particularly for 9-level conf…