Search results for "THD"
showing 10 items of 129 documents
Correction to: Withholding or withdrawing of life-sustaining therapy in older adults (≥ 80 years) admitted to the intensive care unit (Intensive Care…
2018
In the original publication Dr Patrick Meybohm of the Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, Frankfurt University Hospital, Frankfurt, Germany was inadvertently omitted from the list of investigators.
Lipase maturation factor 1 is required for endothelial lipase activity
2011
Lipase maturation factor 1 (Lmf1) is an endoplasmic reticulum (ER) membrane protein involved in the posttranslational folding and/or assembly of lipoprotein lipase (LPL) and hepatic lipase (HL) into active enzymes. Mutations in Lmf1 are associated with diminished LPL and HL activities ("combined lipase deficiency") and result in severe hypertriglyceridemia in mice as well as in human subjects. Here, we investigate whether endothelial lipase (EL) also requires Lmf1 to attain enzymatic activity. We demonstrate that cells harboring a (cld) loss-of-function mutation in the Lmf1 gene are unable to generate active EL, but they regain this capacity after reconstitution with the Lmf1 wild type. Fur…
CARATTERIZZAZIONE DELL’ATTRITO SU COMPONENTI PER APPLICAZIONI ORTODONTICHE MEDIANTE UN SIMULATORE “IN VITRO”
2010
La diffusione delle tecniche a basso attrito (low friction) nell’ambito di terapie ortodontiche per lo spostamento di un dente mediante applicazione di una forza debole (0.5 – 0.7 N) o media (0.7-2.0 N) ha spinto la ricerca del settore odontoiatrico verso lo studio delle forze di attrito nel moto tra archetto ortodontico (archwire) e attacchi ortodontici (brackets). L’esame della letteratura ha mostrato alcuni approcci molto semplificati alla misura dell’attrito, con configurazioni piane, mediante simulazioni poco aderenti a quanto accade nel corso di una reale terapia ortodontica. Il presente lavoro si prefigge uno studio preliminare del fenomeno mediante caratterizzazione della forza di a…
Everolimus With Reduced Tacrolimus Improves Renal Function in De Novo Liver Transplant Recipients: A Randomized Controlled Trial
2012
In a prospective, multicenter, open-label study, de novo liver transplant patients were randomized at day 30±5 to (i) everolimus initiation with tacrolimus elimination (TAC Elimination) (ii) everolimus initiation with reduced-exposure tacrolimus (EVR+Reduced TAC) or (iii) standard-exposure tacrolimus (TAC Control). Randomization to TAC Elimination was terminated prematurely due to a higher rate of treated biopsy-proven acute rejection (tBPAR). EVR+Reduced TAC was noninferior to TAC Control for the primary efficacy endpoint (tBPAR, graft loss or death at 12 months posttransplantation): 6.7% versus 9.7% (-3.0%; 95% CI -8.7, 2.6%; p<0.001 for noninferiority [12% margin]). tBPAR occurred in…
Graphical THD minimization procedure for single phase five-level converters
2017
This paper proposes two graphycal procedure to mitigate h harmonics and to minimize the total harmonic distortion (THD), respectively. The paper considers a five-level inverter and fundamental frequency modulation: it computes the two switching angles able to reduce low order harmonics and able to minimize the THD. Simulation results are obtained and, in order to validate the proposed procedure, an experimental prototype is built and experimental results are carried out. The comparison between simulation and experimental results confirms the accuracy of the proposed graphycal procedure. It is shown that the switching angles to mitigate the third-fifth and the third-fifth-seventh harmonics e…
Soziale Integration und deren Bedeutung für die Lebensqualität nach Laryngektomie
2013
Soziale Netzwerke und gesellschaftliche Teilhabe wirken sich im Allgemeinen positiv auf das psychische Befinden aus. Inwiefern Patienten nach einer Kehlkopfentfernung wieder in die Gesellschaft eingebunden werden, ist jedoch wenig untersucht. Ziel der Studie war es, zu prufen, inwieweit Patienten nach einer Laryngektomie sozial integriert sind und ob die soziale Integration mit bestimmten Bereichen der Lebensqualitat zusammenhangt. In einer multizentrischen Studie wurden 161 Patienten ein Jahr nach Laryngektomie befragt. Die soziale Integration wurde anhand eines Index erhoben. Dieser setzt sich aus Fragen zur sozialen Unterstutzung und dem Fragenkomplex zur Einbindung in die Gesellschaft, …
Sepsis at ICU admission does not decrease 30-day survival in very old patients : a post-hoc analysis of the VIP1 multinational cohort study
2020
AbstractBackgroundThe number of intensive care patients aged ≥ 80 years (Very old Intensive Care Patients; VIPs) is growing. VIPs have high mortality and morbidity and the benefits of ICU admission are frequently questioned. Sepsis incidence has risen in recent years and identification of outcomes is of considerable public importance. We aimed to determine whether VIPs admitted for sepsis had different outcomes than those admitted for other acute reasons and identify potential prognostic factors for 30-day survival.ResultsThis prospective study included VIPs with Sequential Organ Failure Assessment (SOFA) scores ≥ 2 acutely admitted to 307 ICUs in 21 European countries. Of 3869 acutely admi…
Sul potere della Commissione europea di ritirare una proposta legislativa e sui suoi riflessi sugli equilibri istituzionali nel diritto dell'Unione e…
2015
L'articolo si propone di commentare la sentenza del 14 aprile 2015, nella causa C-409/13, con cui la Corte di Giustizia ha risolto un antico contrasto di tesi giuridiche (e politiche) tra il Consiglio dell’Unione europea e la Commissione europea, avente ad oggetto la questione se quest’ultima possa ritirare una proposta legislativa e, se sì, a quali condizioni e in quali casi. Respingendo il ricorso del Consiglio, la Corte ha risolto il conflitto a favore della Commissione, ma ha anche dato alcune indicazioni riguardo a requisiti di ordine sia procedurale che sostanziale che devono essere rispettati ai fini di un “legittimo” esercizio del potere di ritiro. L'articolo si propone anche di sot…
Classification trees for preference data: a distance-based approach
2014
In the framework of preference rankings, when the interest lies in explaining which predictors and which interactions among predictors are able to explain the observed preference structures, the possibility to derive consensus measures using a classi cation tree represents a novelty and an important tool given its easy interpretability. In this work we propose the use of a multivariate decision tree where a weighted Kemeny distance is used both to evaluate the distances between rankings and to de ne an impurity measure to be used in the recursive partitioning. The proposed approach allows also to weight di erently high distances in rankings in the top and in the bottom alternatives.
Efficacy of N-acetylcysteine in the prevention of alcohol relapse-like drinking: Study in long-term ethanol-experienced male rats
2021
Alcohol use disorders are chronic and highly relapsing disorders, thus alcoholic patients have a high rate of recidivism for drug use even after long periods of abstinence. The literature points to the potential usefulness of N-acetylcysteine (NAC) in the management of several substance use disorders probably due to its capacity to restore brain homeostasis of the glutamate system disrupted in addiction. However, there is little evidence in the case of alcohol. The aim of this study was to explore the potential anti-relapse efficacy of NAC using the alcohol deprivation effect (ADE) model in long-term experienced rats. Two experiments were performed in male Wistar rats to: (a) test the effic…