Search results for "THERAPY"
showing 10 items of 12482 documents
The atraumatic restorative treatment approach: an "atraumatic" alternative.
2009
Introduction: Fear and anxiety are part of all human experiences and they may contribute directly to a patient?s behavior. The Atraumatic Restorative Treatment (ART) is a technique that may be an alternative approach in treating special care patients or those who suffer fear or anxiety. Objective: the aim of this paper is to review the ART technique as an alternative to reduce pain and fear during dental treatment. Materials and method: A search for the term ?atraumatic restorative treatment? was carried out in the MEDLINE search engine. References, from the last 10 years, containing at least one of the terms: ?psychological aspects?, ?discomfort?, ?fear?, ?anxiety? or ?pain?, were selected…
Why do antidepressant therapies have such a poor success rate?
2016
Major depression is one of the leading global diseases [1,2]. Treatment is required, because untreated patients suffer not only from impaired emotion [3,4], but also from cognitive [4–6] and somati...
Secukinumab induction and maintenance therapy in moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled, phase II regime…
2013
Abstract Background: Interleukin-17A has major proinflammatory activity in psoriatic lesional skin. Objectives: Assess the efficacy and safety of secukinumab, a fully human IgG1κ monoclonal anti-interleukin-17A antibody, in moderate-to-severe plaque psoriasis in a phase II regimen-finding study. Methods: 404 patients were randomised to subcutaneous placebo (67 patients) or one of three secukinumab 150 mg induction regimens: Single (week 0; 66 patients), Early (weeks 0, 1, 2, 4; 133 patients), and Monthly (weeks 0, 4, 8; 138 patients). The primary outcome was ≥75% improvement from baseline Psoriasis Area and Severity Index (PASI) score at week 12. PASI 75 responders from active treatment …
Free Radicals and Antioxidants in Physical Exercise
1998
The beneficial effects of exercise are well documented. Indeed, it ameliorates diabetes mellitus, improves the plasma lipid profile, increases bone density and may help to lose weight. However, as stated in the old medical saying “the beneficial effects of exercise are lost with exhaustion”. It has been known for some time that exhaustive exercise causes muscle soreness, induces an elevation of cytosolic enzyme activities in blood plasma and may be harmful. In the last decade a considerable amount of information concerning production of free radicals in exhaustive exercise has been obtained. An international symposium took place in Valencia, Spain in 1993 and a book was published on the sub…
Management of Atrial Fibrillation Suppression in AF-HF Comorbidity Therapy (MASCOT) Trial
2003
Inter- [1,2], intra- [3,4], and atrioventricular [51(AV) dyssynchrony are not new concepts, but only recently have attempts been made to correct these disorders in an effort to treat heart failure (HF). A series of trials [6] has addressed partial or comprehensive cardiac resynchronization in patients with severe HF and evidence of cardiac dyssynchrony. Cardiac resynchronization should improve left ventricular (LV) performance; several trials [7-10] have demonstrated improvement in many hemodynamic parameters (LV and aortic pressure, shortening of mitral diastolic regurgitation, synchronized LV and atrial systole, LV volume, reduced myocardial oxygen consumption) and clinical end-points (qu…
Physiotherapy under discussion: A discourse analytic study of physiotherapy students’ clinical education
2008
Clinical education is asserted to be an important period in professional education, being an environment where deep conceptual understanding can develop. The aim of this study was to analyse the in...
Drug safety related to agents used for opioid maintenance therapy
2017
IntroductionThere is only little data regarding drug safety related to agents used for opioid maintenance therapy (OMT).Objectives/aimsTo study drug safety and the reporting behaviour of adverse drug reactions (ADR) related to OMT.MethodsA cross-sectional questionnaire-based telephone survey among physicians providing outpatient OMT in a federal state of Germany (n = 176; response rate = 55.7%) was conducted.ResultsMost of the respondents (n = 97/55.1%) reported that they observe ADR related to buprenorphine, [dihydro]codein and [levo]methdone rarely (n = 38/21.6%), very rarely (n = 39/22.2%) or never (n = 20/11.4%). Methadone was reported to be most frequently associated with the occurrenc…
Personal health promotion through personalized health technologies — Nuadu experience
2009
Poor lifestyles — overweight, unhealthy diet, physical inactivity, sleep deprivation, and stress — are significant risk factors to chronic illnesses, which cause majority of the health care costs. Hence, behavioral change towards healthy lifestyles is one of the keys to health care cost containment. Personal health systems (PHS) offer tools to support behavioral change. As health risks, personal needs and preferences vary from an individual to another, personalization of the PHS is needed. In Nuadu project we have developed a PHS integrating several different personal health technologies. This system was studied in a large (N=354) randomized controlled trial where employees with several hea…
Design and baseline characteristics of participants in the R esearching cardiovascular E vents with a W eekly IN cretin in D iabetes ( REWIND ) trial…
2017
The aim was to determine the effects of dulaglutide, a synthetic once-weekly, injectable human glucagon-like peptide 1 analogue that lowers blood glucose, body weight, appetite and blood pressure, on cardiovascular outcomes. People with type 2 diabetes, aged ≥50 years, with glycated haemoglobin (HbA1c) ≤9.5%, and either a previous cardiovascular event, evidence of cardiovascular disease or ≥2 cardiovascular risk factors were randomly allocated to a weekly subcutaneous injection of either dulaglutide (1.5 mg) or placebo and followed within the ongoing Researching cardiovascular Events with a Weekly INcretin in Diabetes (REWIND) trial every 3 to 6 months. The primary cardiovascular outcome is…
Effects of hypolipidemic and hypoglycemic agents on atherogenic small, dense LDL in Type 2 diabetes
2011
Type 2 diabetes is associated with a cluster of inter-related plasma lipid and lipoprotein abnormalities, including reduced HDL-C, a predominance of small, dense LDL and elevated triglycerides. These abnormalities occur even in prediabetes, before blood sugars rise sufficiently in order to confirm a diagnosis of diabetes, and this transition phase incurs important cardiovascular risk. This is the rationale for paying attention to dyslipidemia through the use of the hypolipidemic, rather than hypoglycemic drugs only. A literature search (by Medline and Scopus) was performed. The authors also manually reviewed the references of selected articles for any pertinent material. Beyond the ‘quantit…